Search Results - "F Lester"

CCN1/CYR61: the very model of a modern matricellular protein by Lau, Lester F.

“…CCN1 (CYR61) is a dynamically expressed, multifunctional matricellular protein that plays essential roles in cardiovascular development during embryogenesis,…”
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Cell surface receptors for CCN proteins by Lau, Lester F.

“…The CCN family (CYR61; CTGF; NOV; CCN1–6; WISP1–3) of matricellular proteins in mammals is comprised of six homologous members that play important roles in…”
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The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing by Lau, Lester F, Jun, Joon-Il

“…During wound healing, the matricellular protein, CCN1, through its adhesion receptors α 6 β 1 and heparan sulphate proteoglycans, activates senescence in…”
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Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets by Jun, Joon-Il, Lau, Lester F.

“…Key Points CCNs are a family of extracellular matrix proteins that regulate diverse aspects of cellular functions, and are involved in inflammation and tissue…”
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Resolution of organ fibrosis by Jun, Joon-Il, Lau, Lester F

“…Fibrosis is the excessive accumulation of extracellular matrix that often occurs as a wound healing response to repeated or chronic tissue injury, and may lead…”
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Tyrosine Kinase Inhibitors for the Treatment of EGFR Mutation-Positive Non–Small-Cell Lung Cancer: A Clash of the Generations by Shah, Riyaz, Lester, Jason F.

“…The availability of 3 generations of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) with different pharmacologic characteristics and…”
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Functions and mechanisms of action of CCN matricellular proteins by Chen, Chih-Chiun, Lau, Lester F.

“…Members of the CCN (CYR61/CTGF/NOV) family have emerged as dynamically expressed, extracellular matrix-associated proteins that play critical roles in…”
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The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing by Jun, Joon-Il, Kim, Ki-Hyun, Lau, Lester F.

“…Neutrophil infiltration constitutes the first step in wound healing, although their timely clearance by macrophage engulfment, or efferocytosis, is critical…”
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Matricellular Protein CCN1 Promotes Regression of Liver Fibrosis through Induction of Cellular Senescence in Hepatic Myofibroblasts by Kim, Ki-Hyun, Chen, Chih-Chiun, Monzon, Ricardo I., Lau, Lester F.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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CCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling by Jun, Joon-Il, Lau, Lester F.

“…Expression of the matricellular protein CCN1 (CYR61) is associated with inflammation and is required for successful wound repair. Here, we show that CCN1 binds…”
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CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB by Kim, Ki-Hyun, Chen, Chih-Chiun, Alpini, Gianfranco, Lau, Lester F

“…Liver cholestatic diseases, which stem from diverse etiologies, result in liver toxicity and fibrosis and may progress to cirrhosis and liver failure. We show…”
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Fructose stimulated de novo lipogenesis is promoted by inflammation by Todoric, Jelena, Di Caro, Giuseppe, Reibe, Saskia, Henstridge, Darren C., Green, Courtney R., Vrbanac, Alison, Ceteci, Fatih, Conche, Claire, McNulty, Reginald, Shalapour, Shabnam, Taniguchi, Koji, Meikle, Peter J., Watrous, Jeramie D., Moranchel, Rafael, Najhawan, Mahan, Jain, Mohit, Liu, Xiao, Kisseleva, Tatiana, Diaz-Meco, Maria T., Moscat, Jorge, Knight, Rob, Greten, Florian R., Lau, Lester F., Metallo, Christian M., Febbraio, Mark A., Karin, Michael

“…Benign hepatosteatosis, affected by lipid uptake, de novo lipogenesis and fatty acid (FA) oxidation, progresses to non-alcoholic steatohepatitis (NASH) on…”
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Matricellular Protein CCN1 Activates a Proinflammatory Genetic Program in Murine Macrophages by Bai, Tao, Chen, Chih-Chiun, Lau, Lester F

“…CCN1 (CYR61) is a matricellular protein that is highly expressed at sites of inflammation and wound repair. In these contexts, CCN1 can modify the activities…”
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Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2 by Cheng, Naiyuan, Kim, Ki-Hyun, Lau, Lester F

“…Senescent cells have long been associated with deleterious effects in aging-related pathologies, although recent studies have uncovered their beneficial roles…”
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Cellular senescence controls fibrosis in wound healing by Jun, Joon-Il, Lau, Lester F

“…Mammalian wound healing involves the rapid synthesis and deposition of extracellular matrix (ECM) to maintain tissue integrity during repair. This process must…”
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The matricellular protein CCN1 in tissue injury repair by Kim, Ki-Hyun, Won, Jong Hoon, Cheng, Naiyuan, Lau, Lester F.

“…The expression of Ccn1 ( Cyr61 ) is essential for cardiovascular development during embryogenesis, whereas in adulthood it is associated with inflammation,…”
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Interplay between CCN1 and Wnt5a in endothelial cells and pericytes determines the angiogenic outcome in a model of ischemic retinopathy by Lee, Sangmi, Elaskandrany, Menna, Lau, Lester F., Lazzaro, Douglas, Grant, Maria B., Chaqour, Brahim

“…CYR61-CTGF-NOV (CCN)1 is a dynamically expressed extracellular matrix (ECM) protein with critical functions in cardiovascular development and tissue repair…”
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Comparative performance of three ceramic bone graft substitutes by Hing, Karin A., Bsc(Hon), PhD, CEng, Wilson, Lester F., MB, BS, BSc(Hon)FRCS, FRCS(Orth), Buckland, Thomas, MEng, PhD

“…Abstract Background context A number of different synthetic calcium-based bone graft substitutes (BGS) are currently available for clinical use. There is,…”
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Externally-Triggered Activation and Inhibition of Optical Pulsating Regimes in Quantum-Dot Mode-locked Lasers by Robertson, Joshua, Ackemann, Thorsten, Lester, Luke F., Hurtado, Antonio

“…Controlled generation and inhibition of externally-triggered picosecond optical pulsating regimes are demonstrated experimentally in a quantum dot mode locked…”
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Pars interarticularis injury in elite athletes – The role of imaging in diagnosis and management by Cheung, King Kenneth, Dhawan, Ranju T., Wilson, Lester F., Peirce, Nicholas S., Rajeswaran, Gajan

“…•Adolescents/young adult athletes are particularly vulnerable to pars injuries due to their immature/developing skeleton.•Pars injuries are prevalent in sports…”
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