Search Results - "F Carroll"

Nanobody-enabled monitoring of kappa opioid receptor states by Che, Tao, English, Justin, Krumm, Brian E., Kim, Kuglae, Pardon, Els, Olsen, Reid H. J., Wang, Sheng, Zhang, Shicheng, Diberto, Jeffrey F., Sciaky, Noah, Carroll, F. Ivy, Steyaert, Jan, Wacker, Daniel, Roth, Bryan L.

“…Recent studies show that GPCRs rapidly interconvert between multiple states although our ability to interrogate, monitor and visualize them is limited by a…”
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Safety and efficacy of an oxycodone vaccine: Addressing some of the unique considerations posed by opioid abuse by Raleigh, M D, Peterson, S J, Laudenbach, M, Baruffaldi, F, Carroll, F I, Comer, S D, Navarro, H A, Langston, T L, Runyon, S P, Winston, S, Pravetoni, M, Pentel, P R

“…Among vaccines aimed at treating substance use disorders, those targeting opioids present several unique medication development challenges. 1) Opioid overdose…”
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Development of κ Opioid Receptor Antagonists by Carroll, F. Ivy, Carlezon, William A

“…κ opioid receptors (KORs) belong to the G-protein-coupled class of receptors (GPCRs). They are activated by the endogenous opioid peptide dynorphin (DYN) and…”
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Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor by Che, Tao, Majumdar, Susruta, Zaidi, Saheem A., Ondachi, Pauline, McCorvy, John D., Wang, Sheng, Mosier, Philip D., Uprety, Rajendra, Vardy, Eyal, Krumm, Brian E., Han, Gye Won, Lee, Ming-Yue, Pardon, Els, Steyaert, Jan, Huang, Xi-Ping, Strachan, Ryan T., Tribo, Alexandra R., Pasternak, Gavril W., Carroll, F. Ivy, Stevens, Raymond C., Cherezov, Vadim, Katritch, Vsevolod, Wacker, Daniel, Roth, Bryan L.

“…The κ-opioid receptor (KOP) mediates the actions of opioids with hallucinogenic, dysphoric, and analgesic activities. The design of KOP analgesics devoid of…”
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Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants by Ku, Zhiqiang, Xie, Xuping, Hinton, Paul R., Liu, Xinli, Ye, Xiaohua, Muruato, Antonio E., Ng, Dean C., Biswas, Sujit, Zou, Jing, Liu, Yang, Pandya, Deepal, Menachery, Vineet D., Rahman, Sachi, Cao, Yu-An, Deng, Hui, Xiong, Wei, Carlin, Kevin B., Liu, Junquan, Su, Hang, Haanes, Elizabeth J., Keyt, Bruce A., Zhang, Ningyan, Carroll, Stephen F., Shi, Pei-Yong, An, Zhiqiang

“…Resistance represents a major challenge for antibody-based therapy for COVID-19 1 – 4 . Here we engineered an immunoglobulin M (IgM) neutralizing antibody…”
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Burden of Gastrointestinal Disease in the United States: 2012 Update by Peery, Anne F, Dellon, Evan S, Lund, Jennifer, Crockett, Seth D, McGowan, Christopher E, Bulsiewicz, William J, Gangarosa, Lisa M, Thiny, Michelle T, Stizenberg, Karyn, Morgan, Douglas R, Ringel, Yehuda, Kim, Hannah P, DiBonaventura, Marco Dacosta, Carroll, Charlotte F, Allen, Jeffery K, Cook, Suzanne F, Sandler, Robert S, Kappelman, Michael D, Shaheen, Nicholas J

“…Background & Aims Gastrointestinal (GI) diseases account for substantial morbidity, mortality, and cost. Statistical analyses of the most recent data are…”
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Structure, Function, and Therapeutic Use of IgM Antibodies by Keyt, Bruce A., Baliga, Ramesh, Sinclair, Angus M., Carroll, Stephen F., Peterson, Marvin S.

“…Natural immunoglobulin M (IgM) antibodies are pentameric or hexameric macro-immunoglobulins and have been highly conserved during evolution. IgMs are initially…”
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Effects of alpha 7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models by Freitas, Kelen, Ghosh, Sudeshna, Ivy Carroll, F., Lichtman, Aron H., Imad Damaj, M.

“…Agonists and positive allosteric modulators (PAMs) of α7 nicotinic acetylcholine receptors (nAChRs) are currently being considered as novel therapeutic…”
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Structure of the human κ-opioid receptor in complex with JDTic by Wu, Huixian, Wacker, Daniel, Mileni, Mauro, Katritch, Vsevolod, Han, Gye Won, Vardy, Eyal, Liu, Wei, Thompson, Aaron A., Huang, Xi-Ping, Carroll, F. Ivy, Mascarella, S. Wayne, Westkaemper, Richard B., Mosier, Philip D., Roth, Bryan L., Cherezov, Vadim, Stevens, Raymond C.

“…Opioid receptors mediate the actions of endogenous and exogenous opioids on many physiological processes, including the regulation of pain, respiratory drive,…”
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Effects of Chronic Social Defeat Stress on Sleep and Circadian Rhythms Are Mitigated by Kappa-Opioid Receptor Antagonism by Wells, Audrey M, Ridener, Elysia, Bourbonais, Clinton A, Kim, Woori, Pantazopoulos, Harry, Carroll, F Ivy, Kim, Kwang-Soo, Cohen, Bruce M, Carlezon, Jr, William A

“…Stress plays a critical role in the neurobiology of mood and anxiety disorders. Sleep and circadian rhythms are affected in many of these conditions. Here we…”
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Molecular mechanism of biased signaling at the kappa opioid receptor by El Daibani, Amal, Paggi, Joseph M., Kim, Kuglae, Laloudakis, Yianni D., Popov, Petr, Bernhard, Sarah M., Krumm, Brian E., Olsen, Reid H. J., Diberto, Jeffrey, Carroll, F. Ivy, Katritch, Vsevolod, Wünsch, Bernhard, Dror, Ron O., Che, Tao

“…The κ-opioid receptor (KOR) has emerged as an attractive drug target for pain management without addiction, and biased signaling through particular pathways of…”
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Nicotinic Acetylcholine Receptor Accessory Subunits Determine the Activity Profile of Epibatidine Derivatives by Corrie, Lu Wenchi, Stokes, Clare, Wilkerson, Jenny L., Carroll, F. Ivy, McMahon, Lance R., Papke, Roger L.

“…Epibatidine is a potent analgetic agent with very high affinity for brain nicotinic acetylcholine receptors (nAChR). We determined the activity profiles of…”
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Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues by Cunniffe, Gráinne M., Díaz-Payno, Pedro J., Sheehy, Eamon J., Critchley, Susan E., Almeida, Henrique V., Pitacco, Pierluca, Carroll, Simon F., Mahon, Olwyn R., Dunne, Aisling, Levingstone, Tanya J., Moran, Conor J., Brady, Robert T., O'Brien, Fergal J., Brama, Pieter A.J., Kelly, Daniel J.

“…Biological scaffolds generated from tissue-derived extracellular matrix (ECM) are commonly used clinically for soft tissue regeneration. Such biomaterials can…”
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Emergence and properties of spice and bath salts: A medicinal chemistry perspective by Lewin, Anita H., Seltzman, Herbert H., Carroll, F. Ivy, Mascarella, S. Wayne, Reddy, P. Anantha

“…Over the past five years the number of internet sites advertising “legal highs” has literally exploded, as have user reports of experiences (both pleasurable…”
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Pharmacological characterization of 5-iodo-A-85380, a β2-selective nicotinic receptor agonist, in mice by Akinola, Lois S, Bagdas, Deniz, Alkhlaif, Yasmin, Jackson, Asti, Gurdap, Cenk O, Rahimpour, Elnaz, Carroll, F. Ivy, Papke, Roger L, Damaj, M. Imad

“…Background: Because of their implications in several pathological conditions, α4β2* nicotinic acetylcholine receptors (nAChRs) are potential targets for the…”
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The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models by Freitas, Kelen, Carroll, F Ivy, Damaj, M Imad

“…The α7 nicotinic acetylcholine receptor (nAChR) subtype is abundantly expressed in the central nervous system and in the periphery. Recent evidence suggests…”
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Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain by Liu, Shiwei Steve, Pickens, Sarah, Burma, Nicole E, Ibarra-Lecue, Ines, Yang, Hongyan, Xue, Lihua, Cook, Chris, Hakimian, Joshua K, Severino, Amie L, Lueptow, Lindsay, Komarek, Kristina, Taylor, Anna M W, Olmstead, Mary C, Carroll, F Ivy, Bass, Caroline E, Andrews, Anne M, Walwyn, Wendy, Trang, Tuan, Evans, Christopher J, Leslie, Frances M, Cahill, Catherine M

“…Pain is a multidimensional experience and negative affect, or how much the pain is "bothersome", significantly impacts the sufferers' quality of life. It is…”
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Antagonists at metabotropic glutamate receptor subtype 5: structure activity relationships and therapeutic potential for addiction by Carroll, F Ivy

“…As a result of intensive investigation, particularly in the pharmaceutical industry, a number of potent and selective metabotropic glutamate receptor subtype 5…”
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Interactions between 2′‐fluoro‐(carbamoylpyridinyl)deschloroepibatidine analogues and acetylcholine‐binding protein inform on potent antagonist activity against nicotinic receptors by Bueno, Renata V., Davis, Samuel, Dawson, Alice, Ondachi, Pauline W., Carroll, F. Ivy, Hunter, William N.

“…Low‐nanomolar binding constants were recorded for a series of six 2′‐fluoro‐(carbamoylpyridinyl)deschloroepibatidine analogues with acetylcholine‐binding…”
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Designer drugs: a medicinal chemistry perspective (II) by Carroll, F. Ivy, Lewin, Anita H., Mascarella, S. Wayne, Seltzman, Herbert H., Reddy, P. Anantha

“…During 2012–2018, the clandestine manufacture of new psychoactive substances (NPS) designed to circumvent substance control regulations increased exponentially…”
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