Search Results - "Fırat, Seyhan Şahan"

Rho-kinase inhibitor, Y-27632, has an antinociceptive effect in mice by Büyükafşar, Kansu, Yalçın, İpek, Kurt, A. Hakan, Tiftik, R. Nalan, Şahan-Fırat, Seyhan, Aksu, Fazilet

“…The possible antinociceptive effect of a Rho-kinase inhibitor, (+)-( R)- trans-4-(1-aminoethyl)- N-(4-pyridyl) cyclohexanecarboxamide dihydrochloride…”
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Role of ACE I/D gene polymorphisms on the effect of ramipril in inflammatory response and myocardial injury in patients undergoing coronary artery bypass grafts by Urhan Küçük, Meral, Sucu, Nehir, Şahan Firat, Seyhan, Aytaçoğlu, Barlas Naim, Vezir, Özden, Bozali, Caner, Canacankatan, Necmiye, Kul, Seval, Tunçtan, Bahar

“…Background Angiotensin-converting enzyme (ACE) inhibitors block angiotensin II formation and release bradykinin, which is effective in the regulation of…”
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Role of cytokine gene polymorphisms on ramipril-altered inflammatory response and myocardial injury in patients undergoing coronary artery bypass surgery by Erden Ertürk,Sema, Urhan Küçük,Meral, Karaca,Kerem Mehmet, Şahan Fırat,Seyhan, Vezir,Özden, Canacankatan,Necmiye, Aytaçoğlu,Barlas Naim, Tunçtan,Bahar, Sucu,Nehir

“…Purpose: Ramipril is effective in treating inflammatory myocardial injury by reducing cytokines such as TNF-α, IL-6, and IL-8. In this study, we investigated…”
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Contribution of Rho-kinase in human gallbladder contractions by Büyükafşar, Kansu, Akça, Tamer, Nalan Tiftik, Rukiye, Şahan-Fırat, Seyhan, Aydın, Süha

“…Rho/Rho-kinase-mediated pathway has been involved in a variety of physiological processes, including Ca 2+ sensitization, which enhances smooth muscle…”
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Rho kinase expression and its central role in ovine gallbladder contractions elicited by a variety of excitatory stimuli by Şahan-Fırat, Seyhan, Tiftik, Rukiye Nalan, Nacak, Muradiye, Büyükafşar, Kansu

“…Rho kinase has contractile activity, which induces Ca 2+ sensitization in various cells. Several receptors are linked to the Rho/Rho-kinase pathway. Therefore,…”
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Soluble epoxide hydrolase inhibitor trifluoromethoxyphenyl‐3‐(1‐propionylpiperidin‐4‐yl)urea prevents hyperalgesia through regulating NLRC4 inflammasome‐related pro‐inflammatory and anti‐inflammatory signaling pathways in the lipopolysaccharide‐induced pain mouse model by Cagli, Ali, Senol, Sefika Pinar, Temiz‐Resitoglu, Meryem, Guden, Demet Sinem, Sari, Ayse Nihal, Sahan‐Firat, Seyhan, Tunctan, Bahar

“…Epoxyeicosatrienoic acids (EETs) have anti‐inflammatory effects and soluble epoxide hydrolase (sEH) inhibition might be a useful therapeutic approach to manage…”
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Koroner arter bypass cerrahisinde ramiprilin miyokardiyal hasar ve inflamatuvar yanıttaki etkisi üzerinde sitokin gen polimorfizmlerinin rolü by Küçük, Meral Urhan, Karaca, Kerem, Fırat, Seyhan Şahan, Vezir, Özden, Canacankatan, Necmiye, Aytaçoğlu, Barlas Naim, Erden, Sema, Tunçtan, Bahar, Sucu, Nehir

“…Amaç: Ramipril, inflamatuar miyokardial hasarın tedavisinde TNF-α, IL-6 ve IL-8 gibi sitokin seviyelerini azaltarak etkili olmaktadır. Çalışmamızda, ramipril…”
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NF‐κB activation mediates LPS‐or zymosan‐induced hypotension and inflammation reversed by BAY61‐3606, a selective Syk inhibitor, in rat models of septic and non‐septic shock by Sahan‐Firat, Seyhan, Temiz‐Resitoglu, Meryem, Guden, Demet Sinem, Senol, Sefika Pinar, Sari, Ayse Nihal, Cil, Meltem, Unsal, Demet, Korkmaz, Belma, Tunctan, Bahar, Malik, Kafait U., Buharalioglu, Cuneyt Kemal

“…Summary We have previously demonstrated that the activation of the spleen tyrosine kinase (Syk)/inhibitory‐κB (IκB)‐α/nuclear factor‐κB (NF‐κB) p65 signalling…”
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Contribution of RhoA/Rho-kinase/MEK1/ERK1/2/iNOS pathway to ischemia/reperfusion-induced oxidative/nitrosative stress and inflammation leading to distant and target organ injury in rats by Sari, A. Nihal, Kacan, Meltem, Unsal, Demet, Sahan Firat, Seyhan, Kemal Buharalioglu, C., Vezir, Ozden, Korkmaz, Belma, Cuez, Tuba, Canacankatan, Necmiye, Sucu, Nehir, Ayaz, Lokman, Tamer Gumus, Lulufer, Gorur, Aysegul, Tunctan, Bahar

“…The small G protein RhoA and its downstream effector Rho-kinase play an important role in various physiopathological processes including ischemia/reperfusion…”
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Involvement of Rho-kinase/IκB-α/NF-κB activation in IL-1β-induced inflammatory response and oxidative stress in human chondrocytes by Tiftik, Rukiye Nalan, Temiz-Reşitoğlu, Meryem, Güden, Demet Sinem, Bayrak, Gülsen, Ün, İsmail, Yılmaz, Şakir Necat, Şahan-Fırat, Seyhan

“…It has been clearly indicated that osteoarthritis (OA) is an inflammatory and degenerative disease that could be promoted by Rho-kinase (ROCK); however, little…”
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NLRX1 ligand, docosahexaenoic acid, ameliorates LPS-induced inflammatory hyperalgesia by decreasing TRAF6/IKK/IκB-α/NF-κB signaling pathway activity by Dilsah Ezgi Yilmaz, Sefika Pinar Senol, Meryem Temiz-Resitoglu, Seyhan Sahan-Firat, Bahar Tunctan

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mTORC2 inhibition by JR-AB2-011 improves IL-1β-induced inflammation, catabolic response, and apoptosis in human chondrocytes through IκB-α/NF-κB p65 by Temiz-Resitoglu, Meryem, Sabrie, Zainab, Tiftik, Rukiye Nalan, Kalkan, Taskın, Aktas-Sukuroglu, Ayca, Malik, Kafait U, Sahan-Firat, Seyhan

“…Osteoarthritis (OA) is a very common chronic joint condition marked by inflammation and cartilage loss. mTOR is a well-known mediator of inflammation, cell…”
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Pro-inflammatory GPR75 and anti-apoptotic phospholipase signaling pathways contribute to the ameliorating effect of soluble epoxide hydrolase inhibition on chronic experimental autoimmune encephalomyelitis in mice by Mehmet Furkan Horat, Sefika Pinar Senol, Omer Bahceli, Meryem Temiz-Resitoglu, Seyhan Sahan-Firat, Serhan Sevim, Bahar Tunctan

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Suppression of TLR4/MyD88/TAK1/NF-κB/COX-2 Signaling Pathway in the Central Nervous System by Bexarotene, a Selective RXR Agonist, Prevents Hyperalgesia in the Lipopolysaccharide-Induced Pain Mouse Model by Senol, Sefika Pinar, Temiz-Resitoglu, Meryem, Guden, Demet Sinem, Sari, Ayse Nihal, Sahan-Firat, Seyhan, Tunctan, Bahar

“…A selective RXR agonist, bexarotene, has been shown to have anti-inflammatory, anti-nociceptive, and neuroprotective effects in several models of numerous…”
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Eicosanoids derived from cytochrome P450 pathway of arachidonic acid and inflammatory shock by Tunctan, Bahar, Senol, Sefika Pinar, Temiz-Resitoglu, Meryem, Guden, Demet Sinem, Sahan-Firat, Seyhan, Falck, John R., Malik, Kafait U.

“…•Shock is classified based on the: Hypovolemic, cardiogenic, obstructive, and vasodilatory.•Vasodilatory (vasoplegic, vasogenic, or distributive) shock may be…”
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mTOR inhibition as a possible pharmacological target in the management of systemic inflammatory response and associated neuroinflammation by lipopolysaccharide challenge in rats by Guden, Demet Sinem, Temiz-Resitoglu, Meryem, Senol, Sefika Pinar, Kibar, Deniz, Yilmaz, Sakir Necat, Tunctan, Bahar, Malik, Kafait U, Sahan-Firat, Seyhan

“…Neuroinflammation plays a critical role during sepsis triggered by microglial activation. Mammalian target of rapamycin (mTOR) has gained attraction in…”
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The role of Syk/IĸB‐α/NF‐ĸB pathway activation in the reversal effect of BAY 61‐3606, a selective Syk inhibitor, on hypotension and inflammation in a rat model of zymosan‐induced non‐septic shock by Unsal, Demet, Kacan, Meltem, Temiz‐Resitoglu, Meryem, Guden, Demet S, Korkmaz, Belma, Sari, Ayse N, Buharalioglu, Cuneyt K, Yildirim‐Yaroglu, Hatice, Tamer‐Gumus, Lulufer, Tunctan, Bahar, Malik, Kafait U, Sahan‐Firat, Seyhan

“…Summary Spleen tyrosine kinase (Syk), a non‐receptor tyrosine kinase, plays an important role in allergic diseases and inflammation. Syk triggers several…”
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Cytochrome P450 1B1 Contributes to Angiotensin II-Induced Hypertension and Associated Pathophysiology by Jennings, Brett L, Sahan-Firat, Seyhan, Estes, Anne M, Das, Kanak, Farjana, Nasreen, Fang, Xiao R, Gonzalez, Frank J, Malik, Kafait U

“…ABSTRACT—Hypertension is the leading cause of cardiovascular diseases, and angiotensin II is one of the major components of the mechanisms that contribute to…”
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Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock by Sari, A. Nihal, Korkmaz, Belma, Serin, Mehmet Sami, Kacan, Meltem, Unsal, Demet, Buharalioglu, C. Kemal, Sahan Firat, Seyhan, Manthati, Vijay L., Falck, John R., Malik, Kafait U., Tunctan, Bahar

“…Objectives We have previously demonstrated that a stable synthetic analog of 20-hydroxyeicosatetraenoic acid (20-HETE), N -(20-hydroxyeicosa-5[ Z ],14[ Z…”
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2,3',4,5'-Tetramethoxystilbene prevents deoxycorticosterone-salt-induced hypertension: contribution of cytochrome P-450 1B1 by Sahan-Firat, Seyhan, Jennings, Brett L, Yaghini, Fariborz A, Song, Chi Young, Estes, Anne M, Fang, Xiao R, Farjana, Nasreen, Khan, Amir I, Malik, Kafait U

“…Reactive oxygen species (ROS) contribute to various models of hypertension, including deoxycorticosterone acetate (DOCA)-salt-induced hypertension. Recently,…”
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