Search Results - "Fürste, Jens P"

crystal structure of an 'All Locked' nucleic acid duplex by Eichert, André, Behling, Katja, Betzel, Christian, Erdmann, Volker A, Fürste, Jens P, Förster, Charlotte

“…'Locked nucleic acids' (LNAs) are known to introduce enhanced bio- and thermostability into natural nucleic acids rendering them powerful tools for diagnostic…”
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Properties of an ‘LNA’-modified ricin RNA aptamer by Förster, Charlotte, Zydek, Martin, Rothkegel, Maika, Wu, Zhiyang, Gallin, Claudia, Geßner, Reinhard, Lisdat, Fred, Fürste, Jens P.

“…► A ricin RNA aptamer was modified with LNAs in the stem region. ► It was examined for ricin binding, thermostability and RNase digestion. ► The LNA-modified…”
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Features of ＂All LNA＂ Duplexes Showing a New Type of Nucleic Acid Geometry by Eichert, André, Betzel, Christian, Förster, Charlotte, Fürste, Jens P., Nitsche, Andreas, Geßner, Reinhard, Oberthür, Dominik

“…“Locked nucleic acids” (LNAs) belong to the backbone-modified nucleic acid family. The 2′-O,4′-C-methylene-β-D-ribofuranose nucleotides are used for single or…”
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Crystallization and preliminary X-ray diffraction data of an LNA 7-mer duplex derived from a ricin aptamer by Förster, Charlotte, Oberthuer, Dominik, Gao, Jiang, Eichert, André, Quast, Frederick G., Betzel, Christian, Nitsche, Andreas, Erdmann, Volker A., Fürste, Jens P.

“…Locked nucleic acids (LNAs) are modified nucleic acids which contain a modified sugar such as β‐d‐2′‐O,4′‐C methylene‐bridged ribofuranose or other sugar…”
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Sequence requirements in the catalytic core of the "10-23" DNA enzyme by Zaborowska, Zaneta, Fürste, Jens P, Erdmann, Volker A, Kurreck, Jens

“…A systematic mutagenesis study of the "10-23" DNA enzyme was performed to analyze the sequence requirements of its catalytic domain. Therefore, each of the 15…”
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tRNASer acceptor stem: conformation and hydration of a microhelix in a crystal structure at 1.8 Å resolution by Förster, Charlotte, Brauer, Arnd B. E., Brode, Svenja, Fürste, Jens P., Betzel, Christian, Erdmann, Volker A.

“…The crystal structure of a serine‐specific tRNA acceptor‐stem microhelix, the binding site for the seryl‐tRNA synthetase, was solved by X‐ray analysis. This…”
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The Seryl-tRNA synthetase/tRNASer acceptor stem interface is mediated via a specific network of water molecules by Eichert, André, Oberthuer, Dominik, Betzel, Christian, Geßner, Reinhard, Erdmann, Volker A., Fürste, Jens P., Förster, Charlotte

“…► Seryl-tRNA synthetase aminoacylates tRNASer isoacceptors with the amino acid serine. ► The tRNASer identity elements are mainly located in the aminoacyl…”
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Mirror-image RNA that binds D-adenosine by Klußmann, Sven, Nolte, Alexis, Bald, Rolf, Erdmann, Volker A, Fürste, Jens P

“…A 58-mer L-RNA ligand that binds to naturally occurring D-adenosine with a dissociation constant of 1.7 microM in solution was identified from a combinatorial…”
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Superposition of two tRNASer acceptor stem crystal structures: comparison of structure, ligands and hydration by Eichert, André, Fürste, Jens P, Ulrich, Alexander, Betzel, Christian, Erdmann, Volker A, Förster, Charlotte

“…We solved the X-ray structures of two Escherichia coli tRNA(Ser) acceptor stem microhelices. As both tRNAs are aminoacylated by the same seryl-tRNA-synthetase,…”
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Comparative crystallization and preliminary X-ray diffraction studies of locked nucleic acid and RNA stems of a tenascin C-binding aptamer by Brode, Svenja, Förster, Charlotte, Brauer, Arnd B. E., Schmidt, Kathrin S., Perbandt, Markus, Meyer, Arne, Rypniewski, Wojciech, Betzel, Christian, Kurreck, Jens, Fürste, Jens P., Erdmann, Volker A.

“…The pharmacokinetic properties of an aptamer against the tumour‐marker protein tenascin‐C have recently been successfully improved by the introduction of…”
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Cocrystallizing natural RNA with its unnatural mirror image: biochemical and preliminary X-ray diffraction analysis of a 5S rRNA A-helix racemate by Förster, Charlotte, Brauer, Arnd B. E., Lehmann, Daniel, Borowski, Tordis, Brode, Svenja, Fürste, Jens P., Perbandt, Markus, Betzel, Christian, Erdmann, Volker A.

“…Chemically synthesized RNAs with the unnatural l‐configuration possess enhanced in vivo stability and nuclease resistance, which is a highly desirable property…”
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Crystal structure of the E. coli tRNA(Arg) aminoacyl stem isoacceptor RR-1660 at 2.0 A resolution by Eichert, André, Perbandt, Markus, Oberthür, Dominik, Schreiber, Angela, Fürste, Jens P, Betzel, Christian, Erdmann, Volker A, Förster, Charlotte

“…Due to the redundancy of the genetic code there exist six mRNA codons for arginine and several tRNA(Arg) isoacceptors which translate these triplets to protein…”
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Gaining Target Access for Deoxyribozymes by Schubert, Steffen, Fürste, Jens P, Werk, Denise, Grunert, Hans-Peter, Zeichhardt, Heinz, Erdmann, Volker A, Kurreck, Jens

“…Antisense oligonucleotides and ribozymes have been used widely to regulate gene expression by targeting mRNAs in a sequence-specific manner. Long RNAs,…”
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Mirror-design of L -oligonucleotide ligands binding to L -arginine by Nolte, Alexis, Klußmann, Sven, Bald, Rolf, Erdmann, Volker A, Fürste, Jens P

“…The high affinity and selectivity of nucleic acid ligands have clearly demonstrated that RNA can be targeted to a variety of molecules. In practice, however,…”
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Crystallization and X-ray diffraction analysis of an 'all-locked' nucleic acid duplex derived from a tRNA(Ser) microhelix by Behling, Katja, Eichert, André, Fürste, Jens P, Betzel, Christian, Erdmann, Volker A, Förster, Charlotte

“…Modified nucleic acids are of great interest with respect to their nuclease resistance and enhanced thermostability. In therapeutical and diagnostic…”
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Molecular cloning of the plasmid RP4 primase region in a multi-host-range tacP expression vector by Fürste, J P, Pansegrau, W, Frank, R, Blöcker, H, Scholz, P, Bagdasarian, M, Lanka, E

“…Plasmid RP4 primase was overproduced by utilizing autoregulated high-level expression vector systems in Escherichia coli and in four other Gram-negative…”
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Escherichia coli tRNA(Arg) acceptor-stem isoacceptors: comparative crystallization and preliminary X-ray diffraction analysis by Eichert, André, Schreiber, Angela, Fürste, Jens P, Perbandt, Markus, Betzel, Christian, Erdmann, Volker A, Förster, Charlotte

“…The aminoacylation of tRNA is a crucial step in cellular protein biosynthesis. Recognition of the cognate tRNA by the correct aminoacyl-tRNA synthetase is…”
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Synthesis and properties of oligodeoxyribonucleotide—polyethylene glycol conjugates by Jäschke, Andres, Fürste, Jens P., Nordhoff, Eckhard, Hillenkamp, Franz, Cech, Dieter, Erdmann, Volker A.

“…Pools of oligonucleotide conjugates consisting of 10 – 400 different molecular species were synthesized. The conjugates contained a varying number of ethylene…”
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Superposition of two tRNA Ser acceptor stem crystal structures: Comparison of structure, ligands and hydration by Eichert, André, Fürste, Jens P., Ulrich, Alexander, Betzel, Christian, Erdmann, Volker A., Förster, Charlotte

“…We solved the X-ray structures of two Escherichia coli tRNA Ser acceptor stem microhelices. As both tRNAs are aminoacylated by the same seryl-tRNA-synthetase,…”
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X-ray diffraction analysis of a human tRNA(Gly) acceptor-stem microhelix isoacceptor at 1.18 A resolution by Eichert, André, Perbandt, Markus, Schreiber, Angela, Fürste, Jens P, Betzel, Christian, Erdmann, Volker A, Förster, Charlotte

“…Interest has been focused on comparative X-ray structure analyses of different tRNA(Gly) acceptor-stem helices. tRNA(Gly)/glycyl-tRNA synthetase belongs to the…”
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