Gender differences in LDL- and HDL-cholesterol subfractions in patients after the acute ischemic stroke and their association with oxidative stress markers

Gender differences in LDL- and HDL-cholesterol subfractions in patients after the acute ischemic stroke and their association with oxidative stress markers

The aim of our study was to examine gender differences of LDL- and HDL-cholesterol subfractions in patients after the acute ischemic stroke with focus on small LDL and HDL subfractions, and their association with oxidative stress markers. In addition, we have monitored the 7-day effect of cholestero...

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Published in:Journal of Clinical Biochemistry and Nutrition Vol. 63; no. 2; pp. 144 - 148
Main Authors: Žitňanová, Ingrid, Šiarnik, Pavel, Füllöp, Matej, Oravec, Stanislav, Penesová, Adela, Ďuračková, Zdenka, Vaská, Eva, Turčáni, Peter, Kollár, Branislav
Format: Journal Article
Language:English
Published: Japan SOCIETY FOR FREE RADICAL RESEARCH JAPAN 01-09-2018
Japan Science and Technology Agency
the Society for Free Radical Research Japan
Subjects:
Antioxidants
Catalase
Cholesterol
Drugs
Gender aspects
Gender differences
Glutathione
Glutathione peroxidase
HDL-subfractions
High density lipoprotein
Ischemia
ischemic stroke
Lipids
Low density lipoprotein
Markers
Original
Oxidative stress
Peroxidase
Sex differences
small dense-LDL-subfractions
Stroke
Superoxide dismutase
Vitamin E
small dense-LDL-subfractions
ischemic stroke
oxidative stress
HDL-subfractions
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Summary:The aim of our study was to examine gender differences of LDL- and HDL-cholesterol subfractions in patients after the acute ischemic stroke with focus on small LDL and HDL subfractions, and their association with oxidative stress markers. In addition, we have monitored the 7-day effect of cholesterol-lowering drugs administered to patients after the acute ischemic stroke, on these subfractions. Eighty two stroke patients and 81 age matched controls were included in this study. Blood was collected from patients within 24 h after the stroke (group A) and re-examined at the 7-day follow-up (group B). We have found gender differences in LDL- and HDL-subfractions in stroke patients, lipid-lowering drugs administered to acute ischemic stroke patients significantly reduced all measured parameters of lipoprotein profile. In the group A LDL1 subfraction positively correlated with activity of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase) indicating a protective role of this subfraction. On the contrary, small HDL subfractions positively correlated with lipoperoxide levels and negatively with trolox equivalent antioxidant capacity in plasma suggesting a negative role of these subfractions. In this work we have confirmed the hypothesis of atherogenic properties of small HDL subfractions and anti-atherogenic properties of large LDL1-subfractions.
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ISSN:0912-0009
1880-5086
DOI:10.3164/jcbn.17-105