Search Results - "Fülöp, Gábor Á"
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A Central Role for TRPM4 in Ca2+-Signal Amplification and Vasoconstriction
Published in International journal of molecular sciences (27-01-2022)“…Transient receptor potential melastatin-4 (TRPM4) is activated by an increase in intracellular Ca2+ concentration and is expressed on smooth muscle cells…”
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2
Chitotriosidase gene polymorphisms and mutations limit the determination of chitotriosidase expression in sarcoidosis
Published in Clinica chimica acta (01-02-2021)“…•Sarcoidosis patients have higher serum chitotriosidase activity than healthy individuals.•Serum chitotriosidase concentration is higher in sarcoidosis…”
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3
New perspectives in the renin-angiotensin-aldosterone system (RAAS) II: albumin suppresses angiotensin converting enzyme (ACE) activity in human
Published in PloS one (01-04-2014)“…About 8% of the adult population is taking angiotensin-converting enzyme (ACE) inhibitors to treat cardiovascular disease including hypertension, myocardial…”
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4
Renin overexpression leads to increased titin-based stiffness contributing to diastolic dysfunction in hypertensive mRen2 rats
Published in American journal of physiology. Heart and circulatory physiology (01-06-2016)“…Hypertension (HTN) is a major risk factor for heart failure. We investigated the influence of HTN on cardiac contraction and relaxation in transgenic renin…”
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5
Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Gα oxidation
Published in Cardiovascular research (21-01-2021)“…Abstract Aims Sodium-glucose-cotransporter-2 inhibitors showed favourable cardiovascular outcomes, but the underlying mechanisms are still elusive. This study…”
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6
Age-Related Alterations in Gait Function in Freely Moving Male C57BL/6 Mice: Translational Relevance of Decreased Cadence and Increased Gait Variability
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (16-08-2019)“…Abstract Age-related gait dysfunction and balance disorders are a major cause of falls and injury in the elderly population. Epidemiological studies have shown…”
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7
Hypertension impairs neurovascular coupling and promotes microvascular injury: role in exacerbation of Alzheimer’s disease
Published in GeroScience (01-08-2017)“…Hypertension in the elderly substantially increases both the risk of vascular cognitive impairment (VCI) and Alzheimer’s disease (AD); however, the underlying…”
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8
Connective tissue growth factor (CTGF) in age-related vascular pathologies
Published in GeroScience (01-12-2017)“…Connective tissue growth factor (CTGF, also known as CCN2) is a matricellular protein expressed in the vascular wall, which regulates diverse cellular…”
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9
Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation–induced impairment of neurovascular coupling responses protecting cognitive function in mice
Published in GeroScience (01-04-2020)“…Whole brain irradiation (WBI, also known as whole brain radiation therapy or WBRT) is a mainstream therapy for patients with identifiable brain metastases and…”
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10
Acute coronary syndrome associated cardiogenic shock in the catheterization laboratory: peripheral veno-arterial extracorporeal membrane oxygenator management and recommendations
Published in Frontiers in medicine (07-11-2023)“…Cardiogenic shock (CS) in acute coronary syndrome (ACS) is a critical disease with high mortality rates requiring complex treatment to maximize patient…”
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11
Sex-specific cardiovascular remodeling leads to a divergent sex-dependent development of heart failure in aged hypertensive rats
Published in GeroScience (24-04-2024)“…Introduction The prevalence of heart failure with preserved ejection fraction (HFpEF) is continuously rising and predominantly affects older women often…”
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12
Swimming competitions in the era of COVID-19: Lessons from successfully hosting the International Swimming League
Published in Physiology international (14-12-2022)“…Organization of mass sport events in the COVID-19 era is utterly complicated. Containments measures, required to avoid a virus outbreak, force athletes to…”
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13
Cerebromicrovascular dysfunction predicts cognitive decline and gait abnormalities in a mouse model of whole brain irradiation-induced accelerated brain senescence
Published in GeroScience (01-02-2017)“…Whole brain irradiation (WBI) is a mainstream therapy for patients with both identifiable brain metastases and prophylaxis for microscopic malignancies…”
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14
Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice
Published in GeroScience (01-12-2017)“…There is correlative evidence that impaired cerebral blood flow (CBF) regulation, in addition to promoting cognitive impairment, is also associated with…”
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15
Correction to: Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice
Published in GeroScience (01-04-2018)“…The original version of this article unfortunately contained an error…”
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16
A Central Role for TRPM4 in Ca 2+ -Signal Amplification and Vasoconstriction
Published in International journal of molecular sciences (27-01-2022)“…Transient receptor potential melastatin-4 (TRPM4) is activated by an increase in intracellular Ca concentration and is expressed on smooth muscle cells (SMCs)…”
Get full text
Journal Article -
17
Role of age-related alterations of the cerebral venous circulation in the pathogenesis of vascular cognitive impairment
Published in American journal of physiology. Heart and circulatory physiology (01-05-2019)“…There has been an increasing appreciation of the role of vascular contributions to cognitive impairment and dementia (VCID) associated with old age. Strong…”
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18
IGF-1 Deficiency Promotes Pathological Remodeling of Cerebral Arteries: A Potential Mechanism Contributing to the Pathogenesis of Intracerebral Hemorrhages in Aging
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (14-03-2019)“…Abstract Clinical and experimental studies show that age-related decline in circulating insulin-like growth factor-1 (IGF-1) levels promotes the pathogenesis…”
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19
The role of atrial fibrillation in vascular cognitive impairment and dementia: epidemiology, pathophysiology, and preventive strategies
Published in GeroScience (13-08-2024)“…The aging population in Europe faces a substantial burden from dementia, with vascular cognitive impairment and dementia (VCID) being a preventable cause…”
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20
Omecamtiv mecarbil evokes diastolic dysfunction and leads to periodic electromechanical alternans
Published in Basic research in cardiology (01-12-2021)“…Omecamtiv mecarbil (OM) is a promising novel drug for improving cardiac contractility. We tested the therapeutic range of OM and identified previously…”
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