Search Results - "Füger, Petra"
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Spastic paraplegia mutation N256S in the neuronal microtubule motor KIF5A disrupts axonal transport in a Drosophila HSP model
Published in PLoS genetics (01-11-2012)“…Hereditary spastic paraplegias (HSPs) comprise a group of genetically heterogeneous neurodegenerative disorders characterized by spastic weakness of the lower…”
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2
Live imaging of synapse development and measuring protein dynamics using two-color fluorescence recovery after photo-bleaching at Drosophila synapses
Published in Nature protocols (01-12-2007)“…Here we describe how to anesthetize and image Drosophila larvae as to follow 'the life history' of identified synapses and synaptic components. This protocol…”
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3
Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging
Published in Nature neuroscience (01-10-2017)“…Neocortical resident microglia are long-lived cells. Füger et al . report that approximately half of these cells survive for the entire lifespan of a mouse…”
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4
Multiple factors contribute to the peripheral induction of cerebral β-amyloidosis
Published in The Journal of neuroscience (30-07-2014)“…Deposition of aggregated amyloid-β (Aβ) peptide in brain is an early event and hallmark pathology of Alzheimer's disease and cerebral Aβ angiopathy…”
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Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis
Published in Journal of Alzheimer's disease (01-01-2010)“…Cholesterol-lowering drugs such as statins influence the proteolytic processing of the amyloid-beta protein precursor (AbetaPP) and are reported to stimulate…”
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6
PP2A and GSK-3β Act Antagonistically to Regulate Active Zone Development
Published in The Journal of neuroscience (16-09-2009)“…The synapse is composed of an active zone apposed to a postsynaptic cluster of neurotransmitter receptors. Each Drosophila neuromuscular junction comprises…”
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7
Correction: Spastic Paraplegia Mutation N256S in the Neuronal Microtubule Motor KIF5A Disrupts Axonal Transport in a HSP Model
Published in PLoS genetics (01-04-2013)Get full text
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Correction: Spastic Paraplegia Mutation N256S in the Neuronal Microtubule Motor KIF5A Disrupts Axonal Transport in a Drosophila HSP Model
Published in PLoS genetics (15-04-2013)Get full text
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9
In vivo imaging of intact Drosophila larvae at sub-cellular resolution
Published in Journal of visualized experiments (10-09-2010)“…Recent improvements in optical imaging, genetically encoded fluorophores and genetic tools allowing efficient establishment of desired transgenic animal lines…”
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10
In vivo Imaging of Intact Drosophila Larvae at Sub-cellular Resolution
Published in Journal of visualized experiments (10-09-2010)Get full text
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11
PP2A and GSK-3beta act antagonistically to regulate active zone development
Published in The Journal of neuroscience (16-09-2009)“…The synapse is composed of an active zone apposed to a postsynaptic cluster of neurotransmitter receptors. Each Drosophila neuromuscular junction comprises…”
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12
Multiple Factors Contribute to the Peripheral Induction of Cerebral -Amyloidosis
Published in The Journal of neuroscience (30-07-2014)“…Deposition of aggregated amyloid-[beta] (A[beta]) peptide in brain is an early event and hallmark pathology of Alzheimer's disease and cerebral A[beta]…”
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13
PP2A and GSK-3{beta} Act Antagonistically to Regulate Active Zone Development
Published in The Journal of neuroscience (16-09-2009)Get full text
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