Search Results - "Först, H."

Macrodomain-containing proteins: regulating new intracellular functions of mono(ADP-ribosyl)ation by Feijs, Karla L. H., Forst, Alexandra H., Verheugd, Patricia, Lüscher, Bernhard

“…The function and regulation of poly(ADP-ribosyl)ation is partially understood. By contrast, little is known about intracellular mono(ADP-ribosyl)ation…”
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Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases by Rosenthal, Florian, Feijs, Karla L H, Frugier, Emilie, Bonalli, Mario, Forst, Alexandra H, Imhof, Ralph, Winkler, Hans C, Fischer, David, Caflisch, Amedeo, Hassa, Paul O, Lüscher, Bernhard, Hottiger, Michael O

“…ADP-ribosylation is an important post-translational protein modification, yet enzymes capable of removing the protein-proximal ADP-ribose were unknown. Human…”
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Recognition of Mono-ADP-Ribosylated ARTD10 Substrates by ARTD8 Macrodomains by Forst, Alexandra H., Karlberg, Tobias, Herzog, Nicolas, Thorsell, Ann-Gerd, Gross, Annika, Feijs, Karla L.H., Verheugd, Patricia, Kursula, Petri, Nijmeijer, Bianca, Kremmer, Elisabeth, Kleine, Henning, Ladurner, Andreas G., Schüler, Herwig, Lüscher, Bernhard

“…ADP-ribosyltransferases (ARTs) catalyze the transfer of ADP-ribose from NAD+ onto substrates. Some ARTs generate in an iterative process ADP-ribose polymers…”
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The interaction of MYC with the trithorax protein ASH2L promotes gene transcription by regulating H3K27 modification by Ullius, Andrea, Lüscher-Firzlaff, Juliane, Costa, Ivan G, Walsemann, Gesa, Forst, Alexandra H, Gusmao, Eduardo G, Kapelle, Karsten, Kleine, Henning, Kremmer, Elisabeth, Vervoorts, Jörg, Lüscher, Bernhard

“…The appropriate expression of the roughly 30,000 human genes requires multiple layers of control. The oncoprotein MYC, a transcriptional regulator, contributes…”
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Recommendations for a standardized report for adult transthoracic echocardiography: a report from the American Society of Echocardiography's Nomenclature and Standards Committee and Task Force for a Standardized Echocardiography Report by Gardin, Julius M, Adams, David B, Douglas, Pamela S, Feigenbaum, Harvey, Forst, David H, Fraser, Alan G, Grayburn, Paul A, Katz, Alan S, Keller, Andrew M, Kerber, Richard E, Khandheria, Bijoy K, Klein, Allan L, Lang, Roberto M, Pierard, Luc A, Quinones, Miguel A, Schnittger, Ingela

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Dynamic subcellular localization of the mono-ADP-ribosyltransferase ARTD10 and interaction with the ubiquitin receptor p62 by Kleine, Henning, Herrmann, Andreas, Lamark, Trond, Forst, Alexandra H, Verheugd, Patricia, Lüscher-Firzlaff, Juliane, Lippok, Barbara, Feijs, Karla Lh, Herzog, Nicolas, Kremmer, Elisabeth, Johansen, Terje, Müller-Newen, Gerhard, Lüscher, Bernhard

“…ADP-ribosylation is a posttranslational modification catalyzed in cells by ADP-ribosyltransferases (ARTD or PARP enzymes). The ARTD family consists of 17…”
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Regulation of NF-κB signalling by the mono-ADP-ribosyltransferase ARTD10 by Verheugd, Patricia, Forst, Alexandra H., Milke, Larissa, Herzog, Nicolas, Feijs, Karla L.H., Kremmer, Elisabeth, Kleine, Henning, Lüscher, Bernhard

“…Adenosine diphosphate-ribosylation is a post-translational modification mediated by intracellular and membrane-associated extracellular enzymes and many…”
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Conscious awareness during general anaesthesia: patients' perceptions, emotions, cognition and reactions by Schwender, D, Kunze-Kronawitter, H, Dietrich, P, Klasing, S, Forst, H, Madler, C

“…We interviewed 45 patients, who answered advertisements (n = 21) or were referred by colleagues (n = 24), about their experience of intraoperative awareness…”
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Prevention, diagnosis, therapy and follow-up care of sepsis: 1st revision of S-2k guidelines of the German Sepsis Society (Deutsche Sepsis-Gesellschaft e.V. (DSG)) and the German Interdisciplinary Association of Intensive Care and Emergency Medicine (Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin (DIVI)) by Reinhart, K, Brunkhorst, F M, Bone, H-G, Bardutzky, J, Dempfle, C-E, Forst, H, Gastmeier, P, Gerlach, H, Gründling, M, John, S, Kern, W, Kreymann, G, Krüger, W, Kujath, P, Marggraf, G, Martin, J, Mayer, K, Meier-Hellmann, A, Oppert, M, Putensen, C, Quintel, M, Ragaller, M, Rossaint, R, Seifert, H, Spies, C, Stüber, F, Weiler, N, Weimann, A, Werdan, K, Welte, T

“…Practice guidelines are systematically developed statements and recommendations that assist the physicians and patients in making decisions about appropriate…”
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A comparison of the adrenocortical response during septic shock and after complete recovery by BRIEGEL, J, SCHELLING, G, HALLER, M, MRAZ, W, FORST, H, PETER, K

“…To compare the adrenocortical response to corticotropin during septic shock and after complete recovery. Prospective clinical study. Multidisciplinary…”
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Does the efficacy of supplemental oxygen for the prevention of postoperative nausea and vomiting depend on the measured outcome, observational period or site of surgery? by Turan, A., Apfel, C. C., Kumpch, M., Danzeisen, O., Eberhart, L. H. J., Forst, H., Heringhaus, C., Isselhorst, C., Trenkler, S., Trick, M., Vedder, I., Kerger, H.

“…Summary High intra‐operative oxygen concentration reportedly reduces postoperative nausea and vomiting (PONV), but recent data are conflicting. Therefore, we…”
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ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation by Feijs, Karla Lh, Kleine, Henning, Braczynski, Anne, Forst, Alexandra H, Herzog, Nicolas, Verheugd, Patricia, Linzen, Ulrike, Kremmer, Elisabeth, Lüscher, Bernhard

“…Although ADP-ribosylation has been described five decades ago, only recently a distinction has been made between eukaryotic intracellular poly- and…”
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Evaluation of a new continuous thermodilution cardiac output monitor in critically ill patients: A prospective criterion standard study by Haller, Mathias, Zollner, Christian, Briegel, Josef, Forst, Helmuth

“…OBJECTIVETo evaluate the accuracy of a new continuous cardiac output monitor (one based on the thermodilution principle) in critically ill patients…”
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Caspase‐dependent cleavage of the mono‐ADP‐ribosyltransferase ARTD10 interferes with its pro‐apoptotic function by Herzog, Nicolas, Hartkamp, Jörg D. H., Verheugd, Patricia, Treude, Fabian, Forst, Alexandra H., Feijs, Karla L. H., Lippok, Barbara E., Kremmer, Elisabeth, Kleine, Henning, Lüscher, Bernhard

“…ADP‐ribosylation is a post‐translational modification that regulates various physiological processes, including DNA damage repair, gene transcription and…”
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Unusual complication following placement of an epidural catheter by Schlipköter, M, Grieser, T, Forst, H

“…We report an unusual complication following placement of a thoracic epidural catheter in a patient that had undergone surgery for pulmonary metastases of…”
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Enhancing Slow Wave Sleep with Sodium Oxybate Reduces the Behavioral and Physiological Impact of Sleep Loss by WALSH, James K, HALL-PORTER, Janine M, GRIFFIN, Kara S, DODSON, Ehren R, FORST, Elizabeth H, CURRY, Denise T, EISENSTEIN, Rhody D, SCHWEITZER, Paula K

“…To investigate whether enhancement of slow wave sleep (SWS) with sodium oxybate reduces the impact of sleep deprivation. Double-blind, parallel group,…”
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Perioperative coagulation management during ascending aorta replacement on apixaban by Dumps, C, Halbeck, E, Schimpf, J, Forst, H

“…The direct oral anticoagulants (DOACs) present a valid therapeutic alternative to vitamin K antagonists in patients with non-valvular atrial fibrillation, for…”
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Risk factors for systemic fungal infections in liver transplant recipients by BRIEGEL, J, FORST, H, PETER, K, SPILL, B, HAAS, A, GRABEIN, B, HALLER, M, KILGER, E, JAUCH, K. W, MAAG, K, RUCKDESCHEL, G

“…The risk factors for systemic fungal infections were analysed retrospectively in 186 orthotopic liver transplant procedures performed in 152 patients between…”
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Prevention, diagnosis, treatment, and follow-up care of sepsis. First revision of the S2k Guidelines of the German Sepsis Society (DSG) and the German Interdisciplinary Association for Intensive and Emergency Care Medicine (DIVI) by Reinhart, K, Brunkhorst, F M, Bone, H-G, Bardutzky, J, Dempfle, C-E, Forst, H, Gastmeier, P, Gerlach, H, Gründling, M, John, S, Kern, W, Kreymann, G, Krüger, W, Kujath, P, Marggraf, G, Martin, J, Mayer, K, Meier-Hellmann, A, Oppert, M, Putensen, C, Quintel, M, Ragaller, M, Rossaint, R, Seifert, H, Spies, C, Stüber, F, Weiler, N, Weimann, A, Werdan, K, Welte, T

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Idiopathic environmental intolerances (formerly multiple chemical sensitivity) psychiatric perspectives by BORNSCHEIN, S, FÖRSTL, H, ZILKER, T

“…Idiopathic environmental intolerances (IEI)/multiple chemical sensitivity (MCS) is characterized by various somatic symptoms which cannot be explained…”
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