Inhaled corticosteroids during and after respiratory syncytial virus-bronchiolitis may decrease subsequent asthma

Respiratory syncytial virus (RSV) bronchiolitis in infancy can lead to bronchial hyper‐reactivity or recurrent obstructive bronchitis. The aim of the present study was to determine whether the type of treatment has an influence on respiratory status after RSV bronchiolitis. The study involved 117 in...

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Bibliographic Details
Published in:	Pediatric allergy and immunology Vol. 11; no. 3; pp. 198 - 202
Main Authors:	Kajosaari, Merja, Syvänen, Pirkko, Förars, Merit, Juntunen-Backman, Kaisu
Format:	Journal Article
Language:	English
Published:	Copenhagen, Denmark Munksgaard International Publishers 01-08-2000 Blackwell
Subjects:	Administration, Inhalation Adrenal Cortex Hormones - administration & dosage Adrenal Cortex Hormones - therapeutic use asthma Asthma - etiology Asthma - prevention & control Biological and medical sciences Bronchiolitis - complications Bronchiolitis - drug therapy Bronchodilator Agents - administration & dosage Bronchodilator Agents - therapeutic use Budesonide - administration & dosage Budesonide - therapeutic use budesonide inhalation therapy Disease Management Female Histamine and antagonists. Allergy Humans Infant Infant, Newborn Male Medical sciences Outcome Assessment (Health Care) Pharmacology. Drug treatments Respiratory Syncytial Virus Infections - complications Respiratory Syncytial Virus Infections - drug therapy RSV-bronchiolitis Human respiratory syncytial virus Budesonide Chemoprophylaxis Infant Wheezing Paramyxoviridae Prevention Local administration Bronchus disease Complication Obstructive pulmonary disease Pneumovirus Human Corticosteroid Pneumovirinae Respiratory disease Antiinflammatory agent Asthma Bronchiolitis Inhalation Infection Virus Mononegavirales Chemotherapy Treatment Viral disease
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Summary:	Respiratory syncytial virus (RSV) bronchiolitis in infancy can lead to bronchial hyper‐reactivity or recurrent obstructive bronchitis. The aim of the present study was to determine whether the type of treatment has an influence on respiratory status after RSV bronchiolitis. The study involved 117 infants (mean age 2.6 months), who needed hospital treatment because of RSV bronchiolitis. The patients were divided randomly into three groups. All received the same symptomatic treatment. Group I children received symptomatic treatment only, group II children were treated for 7 days with inhaled budesonide, 500 µg three times per day, administered via a nebulizer. Group III children received nebulized budesonide, 500 µg twice per day for two months. Follow‐up consisted of out‐patient check‐ups 2 and 6 months after the infection, and telephone contact two years after the infection. Statistically significant differences were seen between the groups. In group I 37% of the children had asthma, in group II 18%, and in group III 12%. According to the present study it seems that inhaled corticosteroid treatment during and after the acute phase of infant RSV bronchiolitis may have a beneficial effect on subsequent bronchial wheezing tendency.
Bibliography:	ArticleID:PAI068 istex:F7804248C6F23C8BFDE6036109DAB5E327E82D14 ark:/67375/WNG-SJ5L3F89-8 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-News-3 content type line 23
ISSN:	0905-6157 1399-3038
DOI:	10.1034/j.1399-3038.2000.00068.x