Search Results - "Föcking, Melanie"

Role of inflammation in the pathogenesis of schizophrenia: A review of the evidence, proposed mechanisms and implications for treatment by Mongan, David, Ramesar, Matthew, Föcking, Melanie, Cannon, Mary, Cotter, David

“…Aim Over the past several decades, there has been a growing research interest in the role of inflammation in the pathogenesis of schizophrenia. This review…”
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Peripheral complement proteins in schizophrenia: A systematic review and meta-analysis of serological studies by Mongan, David, Sabherwal, Sophie, Susai, Subash Raj, Föcking, Melanie, Cannon, Mary, Cotter, David R.

“…There is renewed focus on the complement system in the pathogenesis of schizophrenia. In addition to providing aetiological insights, consistently dysregulated…”
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Proteomic pathway analysis of the hippocampus in schizophrenia and bipolar affective disorder implicates 14-3-3 signaling, aryl hydrocarbon receptor signaling, and glucose metabolism: Potential roles in GABAergic interneuron pathology by Schubert, Klaus Oliver, Föcking, Melanie, Cotter, David R

“…Abstract Neuropathological changes of the hippocampus have been associated with psychotic disorders such as schizophrenia and bipolar disorder. Recent work has…”
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2-D DIGE analysis implicates cytoskeletal abnormalities in psychiatric disease by English, Jane A, Dicker, Patrick, Föcking, Melanie, Dunn, Michael J, Cotter, David R

“…The mechanisms underlying white matter changes in psychiatric disease are not known. We aimed to characterise the differential protein expression in deep white…”
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Evidence that complement and coagulation proteins are mediating the clinical response to omega-3 fatty acids: A mass spectrometry-based investigation in subjects at clinical high-risk for psychosis by Susai, Subash Raj, Healy, Colm, Mongan, David, Heurich, Meike, Byrne, Jonah F., Cannon, Mary, Cagney, Gerard, Wynne, Kieran, Markulev, Connie, Schäfer, Miriam R., Berger, Maximus, Mossaheb, Nilufar, Schlögelhofer, Monika, Smesny, Stefan, Hickie, Ian B., Berger, Gregor E., Chen, Eric Y. H., de Haan, Lieuwe, Nieman, Dorien H., Nordentoft, Merete, Riecher-Rössler, Anita, Verma, Swapna, Street, Rebekah, Thompson, Andrew, Yung, Alison Ruth, Nelson, Barnaby, McGorry, Patrick D., Föcking, Melanie, Amminger, G. Paul, Cotter, David

“…Preliminary evidence indicates beneficial effects of omega-3 polyunsaturated fatty acids (PUFAs) in early psychosis. The present study investigates the…”
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Sample processing time but not storage time affects complement activation markers C4a, C4d, C3a, iC3b, Bb, C5a, and sC5b-9 levels in EDTA-plasma of individuals at clinical high-risk for psychosis by Kodosaki, Eleftheria, Healy, Colm, Byrne, Jonah F., Föcking, Melanie, Cannon, Mary, Perkins, Diana O., Cotter, David, Heurich, Meike

“…The complement system is an important part of the innate immune system and plays a key role in inflammatory processes. Concentrations of complement activation…”
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Monitoring of Implanted Stem Cell Migration in vivo: A Highly Resolved in vivo Magnetic Resonance Imaging Investigation of Experimental Stroke in Rat by Hoehn, Mathias, Küstermann, Ekkehard, Blunk, James, Wiedermann, Dirk, Trapp, Thorsten, Wecker, Stefan, Föcking, Melanie, Arnold, Heinz, Hescheler, Jürgen, Fleischmann, Bernd K., Schwindt, Wolfram, Bührle, Christian

“…In vivo monitoring of stem cells after grafting is essential for a better understanding of their migrational dynamics and differentiation processes and of…”
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Host-Dependent Tumorigenesis of Embryonic Stem Cell Transplantation in Experimental Stroke by Erdö, Franciska, Bührle, Christian, Blunk, James, Hoehn, Mathias, Xia, Ying, Fleischmann, Bernd, Föcking, Melanie, Küstermann, Ekkehardt, Kolossov, Eugen, Hescheler, Jürgen, Hossmann, Konstantin-A., Trapp, Thorsten

“…The therapeutical potential of transplantation of undifferentiated and predifferentiated murine embryonic stem cells for the regeneration of the injured brain…”
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Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis by Heurich, Meike, Föcking, Melanie, Mongan, David, Cagney, Gerard, Cotter, David R.

“…Early identification and treatment significantly improve clinical outcomes of psychotic disorders. Recent studies identified protein components of the…”
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Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress by Föcking, Melanie, Sabherwal, Sophie, Cates, Hannah M., Scaife, Caitriona, Dicker, Patrick, Hryniewiecka, Magdalena, Wynne, Kieran, Rutten, Bart P. F., Lewis, Glyn, Cannon, Mary, Nestler, Eric J., Heurich, Meike, Cagney, Gerard, Zammit, Stanley, Cotter, David R.

“…The complement cascade is a major component of the immune defence against infection, and there is increasing evidence for a role of dysregulated complement in…”
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Complement C4, C4A and C4a – What they do and how they differ by Heurich, Meike, Föcking, Melanie, Cotter, David

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Associations between plasma inflammatory markers and psychotic disorder, depressive disorder and generalised anxiety disorder in early adulthood: A nested case-control study by Mongan, David, Raj Susai, Subash, Föcking, Melanie, Byrne, Jonah F., Zammit, Stan, Cannon, Mary, Cotter, David R.

“…•Low-grade inflammation may occur in association with several mental disorders of early adulthood, but associations with novel markers of chronic inflammation…”
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Functional impairment of cortical AMPA receptors in schizophrenia by Zeppillo, Tommaso, Schulmann, Anton, Macciardi, Fabio, Hjelm, Brooke E., Föcking, Melanie, Sequeira, P. Adolfo, Guella, Ilaria, Cotter, David, Bunney, William E., Limon, Agenor, Vawter, Marquis P.

“…Clinical and preclinical studies suggest that some of the behavioral alterations observed in schizophrenia (SZ) may be mechanistically linked to synaptic…”
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Development of Proteomic Prediction Models for Transition to Psychotic Disorder in the Clinical High-Risk State and Psychotic Experiences in Adolescence by Mongan, David, Föcking, Melanie, Healy, Colm, Susai, Subash Raj, Heurich, Meike, Wynne, Kieran, Nelson, Barnaby, McGorry, Patrick D, Amminger, G Paul, Nordentoft, Merete, Krebs, Marie-Odile, Riecher-Rössler, Anita, Bressan, Rodrigo A, Barrantes-Vidal, Neus, Borgwardt, Stefan, Ruhrmann, Stephan, Sachs, Gabriele, Pantelis, Christos, van der Gaag, Mark, de Haan, Lieuwe, Valmaggia, Lucia, Pollak, Thomas A, Kempton, Matthew J, Rutten, Bart P F, Whelan, Robert, Cannon, Mary, Zammit, Stan, Cagney, Gerard, Cotter, David R, McGuire, Philip

“…Biomarkers that are predictive of outcomes in individuals at risk of psychosis would facilitate individualized prognosis and stratification strategies. To…”
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Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a Nested Case-Control Study of the ALSPAC Longitudinal Birth Cohort by English, Jane A, Lopez, Lorna M, O'Gorman, Aoife, Föcking, Melanie, Hryniewiecka, Magdalena, Scaife, Caitriona, Sabherwal, Sophie, Wynne, Kieran, Dicker, Patrick, Rutten, Bart P F, Lewis, Glynn, Zammit, Stanley, Cannon, Mary, Cagney, Gerard, Cotter, David R

“…The identification of early biological changes associated with the psychotic disorder (PD) is important as it may provide clues to the underlying…”
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Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children by Madrid-Gambin, Francisco, Föcking, Melanie, Sabherwal, Sophie, Heurich, Meike, English, Jane A., O’Gorman, Aoife, Suvitaival, Tommi, Ahonen, Linda, Cannon, Mary, Lewis, Glyn, Mattila, Ismo, Scaife, Caitriona, Madden, Sean, Hyötyläinen, Tuulia, Orešič, Matej, Zammit, Stanley, Cagney, Gerard, Cotter, David R., Brennan, Lorraine

“…The identification of early biomarkers of psychotic experiences (PEs) is of interest because early diagnosis and treatment of those at risk of future disorder…”
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Omega‐3 fatty acid in ultra‐high‐risk psychosis: A systematic review based on functional outcome by Susai, Subash Raj, Sabherwal, Sophie, Mongan, David, Föcking, Melanie, Cotter, David R.

“…Aim Among different types of poly unsaturated fatty acids, omega‐3 fatty acids (FA) play a substantial role in brain development and functioning. This review…”
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Association of Complement and Coagulation Pathway Proteins With Treatment Response in First-Episode Psychosis: A Longitudinal Analysis of the OPTiMiSE Clinical Trial by Susai, Subash Raj, Föcking, Melanie, Mongan, David, Heurich, Meike, Coutts, Fiona, Egerton, Alice, Whetton, Tony, Winter-van Rossum, Inge, Unwin, Richard D, Pollak, Thomas A, Weiser, Mark, Leboyer, Marion, Rujescu, Dan, Byrne, Jonah F, Gifford, George W, Dazzan, Paola, Koutsouleris, Nikolaos, Kahn, René S, Cotter, David R, McGuire, Philip

“…Abstract Background and Hypothesis Treatment response to specific antipsychotic medications is difficult to predict on clinical grounds alone. The current…”
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Differential expression of haptoglobin in individuals at clinical high risk of psychosis and its association with global functioning and clinical symptoms by Healy, Colm, Byrne, Jonah, Raj Suasi, Subash, Föcking, Melanie, Mongan, David, Kodosaki, Eleftheria, Heurich, Meike, Cagney, Gerard, Wynne, Kieran, Bearden, Carrie E., Woods, Scott W., Cornblatt, Barbara, Mathalon, Daniel, Stone, William, Cannon, Tyrone D., Addington, Jean, Cadenhead, Kristin S., Perkins, Diana, Jeffries, Clark, Cotter, David

“…•Few studies have examined inflammatory dysregulation in those at clinical high risk for psychosis (CHR).•Using two cohort studies we observed that haptoglobin…”
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Blood biomarker discovery in drug-free schizophrenia: the contributionof proteomics and multiplex immunoassays by Sabherwal, Sophie, English, Jane A, Föcking, Melanie, Cagney, Gerard, Cotter, David R

“…Recent evidence supports an association between systemic abnormalities and the pathology of psychotic disorders which has led to the search for peripheral…”
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