Search Results - "FÖRSTERMANN, Ulrich"

Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis by Förstermann, Ulrich, Xia, Ning, Li, Huige

“…Major reactive oxygen species (ROS)–producing systems in vascular wall include NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase,…”
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Antioxidant effects of resveratrol in the cardiovascular system by Xia, Ning, Daiber, Andreas, Förstermann, Ulrich, Li, Huige

“…The antioxidant effects of resveratrol (3,5,4'‐trihydroxy‐trans‐stilbene) contribute substantially to the health benefits of this compound. Resveratrol has…”
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Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling by Förstermann, Ulrich, Li, Huige

“…Nitric oxide (NO) produced by the endothelium is an important protective molecule in the vasculature. It is generated by the enzyme endothelial NO synthase…”
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Cardiovascular effects and molecular targets of resveratrol by Li, Huige, Xia, Ning, Förstermann, Ulrich

“…► Resveratrol possesses multiple protective effective against cardiovascular diseases. ► The underlying mechanisms are complex. ► We summarize the…”
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Resveratrol and endothelial nitric oxide by Xia, Ning, Förstermann, Ulrich, Li, Huige

“…Nitric oxide (NO) derived from the endothelial NO synthase (eNOS) has antihypertensive, antithrombotic, anti-atherosclerotic and antiobesogenic properties…”
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Uncoupling of Endothelial Nitric Oxide Synthase in Perivascular Adipose Tissue of Diet-Induced Obese Mice by Xia, Ning, Horke, Sven, Habermeier, Alice, Closs, Ellen I, Reifenberg, Gisela, Gericke, Adrian, Mikhed, Yuliya, Münzel, Thomas, Daiber, Andreas, Förstermann, Ulrich, Li, Huige

“…OBJECTIVE—The present study was conducted to investigate the contribution of perivascular adipose tissue (PVAT) to vascular dysfunction in a mouse model of…”
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Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase by WALLERATH, Thomas, DECKERT, Göran, TERNES, Thomas, ANDERSON, Henrik, HUIGE LI, WITTE, Klaus, FÖRSTERMANN, Ulrich

“…Estrogens can upregulate endothelial nitric oxide synthase (eNOS) in human endothelial cells by increasing eNOS promoter activity and enhancing the binding…”
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Deficiency of Glutathione Peroxidase-1 Accelerates the Progression of Atherosclerosis in Apolipoprotein E-Deficient Mice by Torzewski, Michael, Ochsenhirt, Viola, Kleschyov, Andrei L, Oelze, Matthias, Daiber, Andreas, Li, Huige, Rossmann, Heidi, Tsimikas, Sotirios, Reifenberg, Kurt, Cheng, Fei, Lehr, Hans-Anton, Blankenberg, Stefan, Förstermann, Ulrich, Münzel, Thomas, Lackner, Karl J

“…BACKGROUND—We have recently demonstrated that activity of red blood cell glutathione peroxidase-1 is inversely associated with the risk of cardiovascular…”
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Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol by Xia, Ning, Strand, Susanne, Schlufter, Frank, Siuda, Daniel, Reifenberg, Gisela, Kleinert, Hartmut, Förstermann, Ulrich, Li, Huige

“…•Our group has demonstrated in 2002 that resveratrol enhances eNOS expression.•The molecular mechanisms remain elusive.•The present study is a systematic…”
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Nebivolol Inhibits Superoxide Formation by NADPH Oxidase and Endothelial Dysfunction in Angiotensin II–Treated Rats by Oelze, Matthias, Daiber, Andreas, Brandes, Ralf P, Hortmann, Marcus, Wenzel, Philip, Hink, Ulrich, Schulz, Eberhard, Mollnau, Hanke, von Sandersleben, Alexandra, Kleschyov, Andrei L, Mülsch, Alexander, Li, Huige, Förstermann, Ulrich, Münzel, Thomas

“…Nebivolol is a β1-receptor antagonist with vasodilator and antioxidant properties. Because the vascular NADPH oxidase is an important superoxide source, we…”
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Effects of Angiotensin II Infusion on the Expression and Function of NAD(P)H Oxidase and Components of Nitric Oxide/cGMP Signaling by Mollnau, Hanke, Wendt, Maria, Szöcs, Katalin, Lassègue, Bernard, Schulz, Eberhard, Oelze, Mathias, Li, Huige, Bodenschatz, Martin, August, Michael, Kleschyov, Andrei L, Tsilimingas, Nikolaus, Walter, Ulrich, Förstermann, Ulrich, Meinertz, Thomas, Griendling, Kathy, Münzel, Thomas

“…Angiotensin II infusion causes endothelial dysfunction by increasing NAD(P)H oxidase-mediated vascular superoxide production. However, it remains to be…”
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Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice by Xia, Ning, Daiber, Andreas, Habermeier, Alice, Closs, Ellen I, Thum, Thomas, Spanier, Gerrit, Lu, Qing, Oelze, Matthias, Torzewski, Michael, Lackner, Karl J, Münzel, Thomas, Förstermann, Ulrich, Li, Huige

“…A crucial cause of the decreased bioactivity of nitric oxide (NO) in cardiovascular diseases is the uncoupling of the endothelial NO synthase (eNOS) caused by…”
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Reversal of Endothelial Nitric Oxide Synthase Uncoupling and Up-Regulation of Endothelial Nitric Oxide Synthase Expression Lowers Blood Pressure in Hypertensive Rats by Li, Huige, Witte, Klaus, August, Michael, Brausch, Isolde, Gödtel-Armbrust, Ute, Habermeier, Alice, Closs, Ellen I., Oelze, Mathias, Münzel, Thomas, Förstermann, Ulrich

“…Reversal of Endothelial Nitric Oxide Synthase Uncoupling and Up-Regulation of Endothelial Nitric Oxide Synthase Expression Lowers Blood Pressure in…”
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Estrogen Receptor Signaling and the PI3K/Akt Pathway Are Involved in Betulinic Acid-Induced eNOS Activation by Hohmann, Nicolas, Xia, Ning, Steinkamp-Fenske, Katja, Förstermann, Ulrich, Li, Huige

“…Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid with anti-inflammatory, antiviral and anti-cancer properties. Beneficial cardiovascular…”
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Inhibitors of Histone Deacetylation Downregulate the Expression of Endothelial Nitric Oxide Synthase and Compromise Endothelial Cell Function in Vasorelaxation and Angiogenesis by Rössig, Lothar, Li, Huige, Fisslthaler, Beate, Urbich, Carmen, Fleming, Ingrid, Förstermann, Ulrich, Zeiher, Andreas M, Dimmeler, Stefanie

“…ABSTRACT—The histone deacetylase (HDAC) inhibitor trichostatin A (TSA) inhibits hypoxia-stimulated angiogenesis. Endothelial nitric oxide synthase…”
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Artichoke, cynarin and cyanidin downregulate the expression of inducible nitric oxide synthase in human coronary smooth muscle cells by Xia, Ning, Pautz, Andrea, Wollscheid, Ursula, Reifenberg, Gisela, Förstermann, Ulrich, Li, Huige

“…Artichoke (Cynara scolymus L.) is one of the world's oldest medicinal plants with multiple health benefits. We have previously shown that artichoke leaf…”
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Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity by Bollmann, Franziska, Art, Julia, Henke, Jenny, Schrick, Katharina, Besche, Verena, Bros, Matthias, Li, Huige, Siuda, Daniel, Handler, Norbert, Bauer, Florian, Erker, Thomas, Behnke, Felix, Mönch, Bettina, Härdle, Lorena, Hoffmann, Markus, Chen, Ching-Yi, Förstermann, Ulrich, Dirsch, Verena M, Werz, Oliver, Kleinert, Hartmut, Pautz, Andrea

“…Resveratrol shows beneficial effects in inflammation-based diseases like cancer, cardiovascular and chronic inflammatory diseases. Therefore, the molecular…”
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Red fruit (Pandanus conoideus Lam) oil stimulates nitric oxide production and reduces oxidative stress in endothelial cells by Xia, Ning, Schirra, Christian, Hasselwander, Solveig, Förstermann, Ulrich, Li, Huige

“…[Display omitted] •This is the first study showing that red fruit oil (RFO) stimulates nitric oxide production in endothelial cells.•RFO contains highly potent…”
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Regulation of NADPH Oxidase-Mediated Superoxide Production by Acetylation and Deacetylation by Xia, Ning, Tenzer, Stefan, Lunov, Oleg, Karl, Martin, Simmet, Thomas, Daiber, Andreas, Münzel, Thomas, Reifenberg, Gisela, Förstermann, Ulrich, Li, Huige

“…Oral treatment of apolipoprotein E-knockout (ApoE-KO) mice with the putative sirtuin 1 (SIRT1) activator resveratrol led to a reduction of nicotinamide adenine…”
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Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus by Wenzel, Philip, Daiber, Andreas, Oelze, Matthias, Brandt, Moritz, Closs, Ellen, Xu, Jian, Thum, Thomas, Bauersachs, Johann, Ertl, Georg, Zou, Ming-Hui, Förstermann, Ulrich, Münzel, Thomas

“…Abstract Objective HMG-CoA reductase inhibitors have been shown to upregulate GTP cyclohydrolase I (GTPCH-I), the key enzyme for tetrahydrobiopterin de novo…”
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