Search Results - "Ezzat, Shahira M"
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Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health
Published in ACS omega (26-05-2020)“…Quercetin (Que) and its derivatives are naturally occurring phytochemicals with promising bioactive effects. The antidiabetic, anti-inflammatory, antioxidant,…”
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Metabolomics in the Context of Plant Natural Products Research: From Sample Preparation to Metabolite Analysis
Published in Metabolites (15-01-2020)“…Plant-derived natural products have long been considered a valuable source of lead compounds for drug development. Natural extracts are usually composed of…”
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In-depth hepatoprotective mechanistic study of Phyllanthus niruri: In vitro and in vivo studies and its chemical characterization
Published in PloS one (01-01-2020)“…Phyllanthus niruri L. is a widespread tropical plant which is used in Ayurvedic system for liver and kidney ailments. The present study aims at specifying the…”
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Comparative metabolite profiling of four polyphenol rich Morus leaves extracts in relation to their antibiofilm activity against Enterococcus faecalis
Published in Scientific reports (23-11-2022)“…Enterococci are a common cause of urinary tract infections. The severity of enterococcal infections is associated with their ability to form biofilms. Morus…”
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Anti-estrogenic and anti-aromatase activities of citrus peels major compounds in breast cancer
Published in Scientific reports (29-03-2021)“…Estrogen signaling is crucial for breast cancer initiation and progression. Endocrine-based therapies comprising estrogen receptor (ER) modulators and…”
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A comparative UPLC-orbitrap-MS-based metabolite profiling of three Pelargonium species cultivated in Egypt
Published in Scientific reports (01-10-2024)“…Several Pelargonium species are cultivated mainly to produce essential oils used in perfume industry and for ornamental purposes. Although the chemical…”
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An approach for an enhanced anticancer activity of ferulic acid-loaded polymeric micelles via MicroRNA-221 mediated activation of TP53INP1 in caco-2 cell line
Published in Scientific reports (24-01-2024)“…Ferulic acid (FA) has powerful antioxidant and antitumor activities, but it has low bioavailability owing to its poor water solubility. Our aim is to formulate…”
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In silico and in vitro anti-inflammatory study of phenolic compounds isolated from Eucalyptus maculata resin
Published in Scientific reports (06-02-2023)“…Plant resins are rich in bioactive compounds with high medicinal values. However, the chemistry and anti-inflammatory activity of the resins produced by trees…”
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Symphytum Species: A Comprehensive Review on Chemical Composition, Food Applications and Phytopharmacology
Published in Molecules (Basel, Switzerland) (18-06-2019)“…species belongs to the Boraginaceae family and have been used for centuries for bone breakages, sprains and rheumatism, liver problems, gastritis, ulcers, skin…”
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Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights
Published in Molecular nutrition & food research (01-04-2024)“…Phenethyl isothiocyanate (PEITC), a compound derived from cruciferous vegetables, has garnered attention for its anticancer properties. This review synthesizes…”
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Investigation of the phytochemical composition, antioxidant, antibacterial, anti-osteoarthritis, and wound healing activities of selected vegetable waste
Published in Scientific reports (10-08-2023)“…Agri-food wastes, produced following industrial food processing, are mostly discarded, leading to environmental hazards and losing the nutritional and…”
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Optimization of an Extraction Solvent for Angiotensin-Converting Enzyme Inhibitors from Hibiscus sabdariffa L. Based on Its UPLC-MS/MS Metabolic Profiling
Published in Molecules (Basel, Switzerland) (14-05-2020)“…species (Malvaceae) have been long used as an antihypertensive folk remedy. The aim of our study was to specify the optimum solvent for extraction of the…”
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Looking at Marine-Derived Bioactive Molecules as Upcoming Anti-Diabetic Agents: A Special Emphasis on PTP1B Inhibitors
Published in Molecules (Basel, Switzerland) (15-12-2018)“…Diabetes mellitus (DM) is a chronic metabolic disease with high morbimortality rates. DM has two types: type 1, which is often associated with a total…”
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Phenolics from Physalis peruviana fruits ameliorate streptozotocin-induced diabetes and diabetic nephropathy in rats via induction of autophagy and apoptosis regression
Published in Biomedicine & pharmacotherapy (01-10-2021)“…The objective of our study was to evaluate the effect of Physalis peruviana L. fruits in the management of diabetes and diabetic nephropathy in relation to its…”
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Downregulation of MMP1 expression mediates the anti-aging activity of Citrus sinensis peel extract nanoformulation in UV induced photoaging in mice
Published in Biomedicine & pharmacotherapy (01-06-2021)“…Aging of the skin is a complicated bioprocess that is affected by constant exposure to ultraviolet irradiation. The application of herbal-based anti-aging…”
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Mushrooms-Rich Preparations on Wound Healing: From Nutritional to Medicinal Attributes
Published in Frontiers in pharmacology (16-09-2020)“…Mushrooms have a significant role in human diet as functional food and as a nutraceutical resource. The combination of its umami flavor, protein, vitamins,…”
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Development of Semisynthetic Apoptosis-Inducing Agents Based on Natural Phenolic Acids Scaffold: Design, Synthesis and In-Vitro Biological Evaluation
Published in Molecules (Basel, Switzerland) (01-10-2022)“…A crucial target in drug research is magnifying efficacy and decreasing toxicity. Therefore, using natural active constituents as precursors will enhance both…”
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Potential Valorization of Edible Nuts By-Products: Exploring the Immune-Modulatory and Antioxidants Effects of Selected Nut Shells Extracts in Relation to Their Metabolic Profiles
Published in Antioxidants (25-02-2022)“…The immune system is a potent army that defends our body against various infections and diseases through innate and adaptive immunity. Herbal medicine is one…”
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Nanotechnology in leukemia: diagnosis, efficient-targeted drug delivery, and clinical trials
Published in European journal of medical research (05-12-2023)“…Leukemia is a group of malignant disorders which affect the blood and blood-forming tissues in the bone marrow, lymphatic system, and spleen. Many types of…”
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NMDA Inhibitors: A Potential Contrivance to Assist in Management of Alzheimer's Disease
Published in Combinatorial chemistry & high throughput screening (01-01-2023)“…Alzheimer's disease (AD) is an increasingly common neurodegenerative disease that attracts the attention of researchers and medical community in order to…”
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