Search Results - "Ezponda, Teresa"

Molecular pathways: deregulation of histone h3 lysine 27 methylation in cancer-different paths, same destination by Ezponda, Teresa, Licht, Jonathan D

“…Methylation of lysine 27 on histone H3 (H3K27me), a modification associated with gene repression, plays a critical role in regulating the expression of genes…”
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EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation by Béguelin, Wendy, Popovic, Relja, Teater, Matt, Jiang, Yanwen, Bunting, Karen L., Rosen, Monica, Shen, Hao, Yang, Shao Ning, Wang, Ling, Ezponda, Teresa, Martinez-Garcia, Eva, Zhang, Haikuo, Zheng, Yupeng, Verma, Sharad K., McCabe, Michael T., Ott, Heidi M., Van Aller, Glenn S., Kruger, Ryan G., Liu, Yan, McHugh, Charles F., Scott, David W., Chung, Young Rock, Kelleher, Neil, Shaknovich, Rita, Creasy, Caretha L., Gascoyne, Randy D., Wong, Kwok-Kin, Cerchietti, Leandro, Levine, Ross L., Abdel-Wahab, Omar, Licht, Jonathan D., Elemento, Olivier, Melnick, Ari M.

“…The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B cells and targeted by somatic mutations in B cell lymphomas. Here, we find…”
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Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single-cell resolution by Ainciburu, Marina, Ezponda, Teresa, Berastegui, Nerea, Alfonso-Pierola, Ana, Vilas-Zornoza, Amaia, San Martin-Uriz, Patxi, Alignani, Diego, Lamo-Espinosa, Jose, San-Julian, Mikel, Jiménez-Solas, Tamara, Lopez, Felix, Muntion, Sandra, Sanchez-Guijo, Fermin, Molero, Antonieta, Montoro, Julia, Serrano, Guillermo, Diaz-Mazkiaran, Aintzane, Lasaga, Miren, Gomez-Cabrero, David, Diez-Campelo, Maria, Valcarcel, David, Hernaez, Mikel, Romero, Juan P, Prosper, Felipe

“…Early hematopoiesis is a continuous process in which hematopoietic stem and progenitor cells (HSPCs) gradually differentiate toward specific lineages. Aging…”
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Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation by Popovic, Relja, Martinez-Garcia, Eva, Giannopoulou, Eugenia G, Zhang, Quanwei, Zhang, Qingyang, Ezponda, Teresa, Shah, Mrinal Y, Zheng, Yupeng, Will, Christine M, Small, Eliza C, Hua, Youjia, Bulic, Marinka, Jiang, Yanwen, Carrara, Matteo, Calogero, Raffaele A, Kath, William L, Kelleher, Neil L, Wang, Ji-Ping, Elemento, Olivier, Licht, Jonathan D

“…Overexpression of the histone methyltransferase MMSET in t(4;14)+ multiple myeloma patients is believed to be the driving factor in the pathogenesis of this…”
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UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition by Ezponda, Teresa, Dupéré-Richer, Daphné, Will, Christine M., Small, Eliza C., Varghese, Nobish, Patel, Tej, Nabet, Behnam, Popovic, Relja, Oyer, Jon, Bulic, Marinka, Zheng, Yupeng, Huang, Xiaoxiao, Shah, Mrinal Y., Maji, Sayantan, Riva, Alberto, Occhionorelli, Manuela, Tonon, Giovanni, Kelleher, Neil, Keats, Jonathan, Licht, Jonathan D.

“…Loss or inactivation of the histone H3K27 demethylase UTX occurs in several malignancies, including multiple myeloma (MM). Using an isogenic cell system, we…”
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Characterization of complete lncRNAs transcriptome reveals the functional and clinical impact of lncRNAs in multiple myeloma by Carrasco-Leon, Arantxa, Ezponda, Teresa, Meydan, Cem, Valcárcel, Luis V., Ordoñez, Raquel, Kulis, Marta, Garate, Leire, Miranda, Estíbaliz, Segura, Victor, Guruceaga, Elisabeth, Vilas-Zornoza, Amaia, Alignani, Diego, Pascual, Marién, Amundarain, Ane, Castro-Labrador, Laura, Martín-Uriz, Patxi San, El-Omri, Halima, Taha, Ruba Y., Calasanz, Maria J., Planes, Francisco J., Paiva, Bruno, Mason, Christopher E., San Miguel, Jesús F., Martin-Subero, José I., Melnick, Ari, Prosper, Felipe, Agirre, Xabier

“…Multiple myeloma (MM) is an incurable disease, whose clinical heterogeneity makes its management challenging, highlighting the need for biological features to…”
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Deregulation of linc-PINT in acute lymphoblastic leukemia is implicated in abnormal proliferation of leukemic cells by Garitano-Trojaola, Andoni, José-Enériz, Edurne San, Ezponda, Teresa, Unfried, Juan Pablo, Carrasco-León, Arantxa, Razquin, Nerea, Barriocanal, Marina, Vilas-Zornoza, Amaia, Sangro, Bruno, Segura, Victor, Prósper, Felipe, Fortes, Puri, Agirre, Xabier

“…Long Non-Coding RNAs (lncRNAs) are functional RNAs longer than 200 nucleotides in length. Several lncRNAs are involved in cell proliferation and are…”
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Single-cell transcriptional profile of CD34+ hematopoietic progenitor cells from del(5q) myelodysplastic syndromes and impact of lenalidomide by Serrano, Guillermo, Berastegui, Nerea, Díaz-Mazkiaran, Aintzane, García-Olloqui, Paula, Rodriguez-Res, Carmen, Huerga-Dominguez, Sofia, Ainciburu, Marina, Vilas-Zornoza, Amaia, Martin-Uriz, Patxi San, Aguirre-Ruiz, Paula, Ullate-Agote, Asier, Ariceta, Beñat, Lamo-Espinosa, Jose-Maria, Acha, Pamela, Calvete, Oriol, Jimenez, Tamara, Molero, Antonieta, Montoro, Maria Julia, Díez-Campelo, Maria, Valcarcel, David, Solé, Francisco, Alfonso-Pierola, Ana, Ochoa, Idoia, Prósper, Felipe, Ezponda, Teresa, Hernaez, Mikel

“…While myelodysplastic syndromes with del(5q) (del(5q) MDS) comprises a well-defined hematological subgroup, the molecular basis underlying its origin remains…”
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Alternative splicing: an emerging topic in molecular and clinical oncology by Pajares, María J, PhD, Ezponda, Teresa, MSc, Catena, Raúl, MSc, Calvo, Alfonso, PhD, Pio, Ruben, Prof, Montuenga, Luis M, Prof

“…Summary Alternative pre-mRNA splicing is a key molecular event that allows for protein diversity. Through this process, a single gene increases its coding…”
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SimiC enables the inference of complex gene regulatory dynamics across cell phenotypes by Peng, Jianhao, Serrano, Guillermo, Traniello, Ian M., Calleja-Cervantes, Maria E., Chembazhi, Ullas V., Bangru, Sushant, Ezponda, Teresa, Rodriguez-Madoz, Juan Roberto, Kalsotra, Auinash, Prosper, Felipe, Ochoa, Idoia, Hernaez, Mikel

“…Single-cell RNA-Sequencing has the potential to provide deep biological insights by revealing complex regulatory interactions across diverse cell phenotypes at…”
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Expression of Tumor-Derived Vascular Endothelial Growth Factor and Its Receptors Is Associated With Outcome in Early Squamous Cell Carcinoma of the Lung by PAJARES, María J, AGORRETA, Jackeline, WISTUBA, Ignacio I, BEHRENS, Carmen, TIMSIT, Jean-Francois, PIO, Ruben, FIELD, John K, MONTUENGA, Luis M, LARRAYOZ, Marta, VESIN, Aurelien, EZPONDA, Teresa, ZUDAIRE, Isabel, TORRE, Wenceslao, LOZANO, María D, BRAMBILLA, Elisabeth, BRAMBILLA, Christian

“…Antiangiogenic therapies targeting the vascular endothelial growth factor (VEGF) pathway have yielded more modest clinical benefit to patients with…”
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Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape by Nabet, Behnam, Ó Broin, Pilib, Reyes, Jaime M., Shieh, Kevin, Lin, Charles Y., Will, Christine M., Popovic, Relja, Ezponda, Teresa, Bradner, James E., Golden, Aaron A., Licht, Jonathan D.

“…Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these…”
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The Oncoprotein SF2/ASF Promotes Non-Small Cell Lung Cancer Survival by Enhancing Survivin Expression by EZPONDA, Teresa, PAJARES, Maria J, AGORRETA, Jackeline, ECHEVESTE, José I, LOPEZ-PICAZO, José M, TORRE, Wenceslao, PIO, Ruben, MONTUENGA, Luis M

“…SF2/ASF is a splicing factor recently described as an oncoprotein. In the present work, we examined the role of SF2/ASF in human non-small cell lung cancer…”
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Development of a novel splice array platform and its application in the identification of alternative splice variants in lung cancer by Pio, Ruben, Blanco, David, Pajares, Maria Jose, Aibar, Elena, Durany, Olga, Ezponda, Teresa, Agorreta, Jackeline, Gomez-Roman, Javier, Anton, Miguel Angel, Rubio, Angel, Lozano, Maria D, López-Picazo, Jose M, Subirada, Francesc, Maes, Tamara, Montuenga, Luis M

“…Microarrays strategies, which allow for the characterization of thousands of alternative splice forms in a single test, can be applied to identify differential…”
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Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling by Sena, Laura A., Li, Sha, Jairaman, Amit, Prakriya, Murali, Ezponda, Teresa, Hildeman, David A., Wang, Chyung-Ru, Schumacker, Paul T., Licht, Jonathan D., Perlman, Harris, Bryce, Paul J., Chandel, Navdeep S.

“…It is widely appreciated that T cells increase glycolytic flux during activation, but the role of mitochondrial flux is unclear. Here, we have shown that…”
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Molecular Pathways: Deregulation of Histone 3 Lysine 27 Methylation in Cancer—Different Paths, Same Destination by Ezponda, Teresa, Licht, Jonathan D.

“…Methylation of lysine 27 on histone 3 (H3K27me), a modification associated with gene repression, plays a critical role in regulating the expression of genes…”
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KDM6A regulates immune response genes in multiple myeloma by Dupéré-Richer, Daphné, Riva, Alberto, Barwick, Benjamin G., Maji, Sayantan, Casellas Román, Heidi, Li, Jianping, De, Umasankar, Sobh, Amin, Quickstad, Gabrielle, Piper, Crissandra, Kulis, Marta, Ezponda, Teresa, Martín-Subero, José Ignacio, Tonon, Giovanni, Zhang, Weizhou, Mitsiades, Constantine S., Boise, Lawrence H., Bennett, Richard L., Licht, Jonathan D.

“…•KDM6A binds NLRC5 and CIITA loci and regulates their transcription in myeloma cells.•Decreased expression of NLRC5 and CIITA in KDM6A-deficient cell lines can…”
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Bone Marrow Cytokines Concentrations in Myelodysplastic Neoplasms: Its Correlation with the Immune Populations and Clonal Hematopoiesis by Molero Yordi, Antonieta, Peralta Garzón, Soraya, Gallur, Laura, Tazon, Barbara, Medina, Daniel, Navarro Garces, Victor, Montoro, Maria Julia, Saumell, Silvia, Jimenez, Tamara, López Cadenas, Félix, Ezponda, Teresa, Pierola, Ana Alfonso, Prosper, Felipe, Diez-Campelo, Maria, Salamero, Olga, Pérez González, Ana, Garrido Paniagua, Sara, Valcarcel, David

“…Background: Myelodysplastic neoplasms (MDS) are a clonal, heterogenic disease of the hematopoietic stem cell. Pathophysiology is mainly related to intrinsic…”
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The Transcriptional Impact of 5q Deletion in MDS at Single Cell Resolution by Diaz-Mazkiaran, Aintzane, Serrano, Guillermo, Berastegui, Nerea, Garcia-Olloqui, Paula, Huerga, Sofia, Pierola, Ana Alfonso, Ullate-Agote, Asier, Ariceta, Beñat, Ainciburu, Marina, Vilas-Zornoza, Amaia, San-Martin, Patxi, Aguirre-Ruiz, Paula, Lamo De Espinosa, Jose Maria, Acha, Pamela, Calvete, Oriol, Jimenez, Tamara, Molero, Antonieta, Montoro, Julia, Diez-Campelo, Maria, Valcarcel, David, Sole, Francesc, Ochoa, Idoia, Ezponda, Teresa, Prosper, Felipe, Hernaez, Mikel

“…Introduction: Myelodysplastic syndromes with 5q deletion (del(5q) MDS) are characterized by two commonly deleted regions (CDRs): 5q31 and 5q32-33. Although…”
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MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents by Shah, M Y, Martinez-Garcia, E, Phillip, J M, Chambliss, A B, Popovic, R, Ezponda, T, Small, E C, Will, C, Phillip, M P, Neri, P, Bahlis, N J, Wirtz, D, Licht, J D

“…MMSET/WHSC1 is a histone methyltransferase (HMT) overexpressed in t(4;14)+ multiple myeloma (MM) patients, believed to be the driving factor in the…”
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