Search Results - "Ezelarab, Hend A.A."

New S- and N-alkyl functionalized bis-1,2,4-Triazolyl-based Derivatives as Potential Dual EGFRWT and EGFRT790M Inhibitors: Synthesis, Anti-proliferative Evaluation, Molecular Docking Study and ADMET Studies by Ahmed, Abdelraheem M., Aboelez, Moustafa O., Ezelarab, Hend A.A., Khodairy, Ahmed, Hassan, Abdelfattah, User, Marium Abo, Salah, Hanan

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Recent updates of fluoroquinolones as antibacterial agents by Ezelarab, Hend A. A., Abbas, Samar H., Hassan, Heba A., Abuo‐Rahma, Gamal El‐Din A.

“…Fluoroquinolones remain one of the most important kind of antibacterial agents used nowadays. The emergence of more virulent and resistant strains of bacteria…”
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Inflammatory setting, therapeutic strategies targeting some pro-inflammatory cytokines and pathways in mitigating ischemia/reperfusion-induced hepatic injury: a comprehensive review by Aboelez, Moustafa O., Ezelarab, Hend A. A., Alotaibi, Ghallab, Abouzed, Deiaa E. Elsayed

“…Ischemia/reperfusion injury (IRI) is a key determining agent in the pathophysiology of clinical organ dysfunction. It is characterized by an aseptic local…”
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Multimodal modulation of hepatic ischemia/reperfusion-induced injury by phytochemical agents: A mechanistic evaluation of hepatoprotective potential and safety profiles by Elsayed Abouzed, Deiaa E., Ezelarab, Hend A.A., Selim, Heba Mohammed Refat M., Elsayed, Mahmoud M.A., El Hamd, Mohamed A., Aboelez, Moustafa O.

“…•Ischemia reperfusion, linked to early/late graft rejection after liver transplant, liver failure after many liver surgeries.•Phytochemical agents exhibited…”
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New antiproliferative 3-substituted oxindoles inhibiting EGFR/VEGFR-2 and tubulin polymerization by Ezelarab, Hend A. A., Ali, Taha F. S., Abbas, Samar H., Sayed, Ahmed M., Beshr, Eman A. M., Hassan, Heba A.

“…New 3-substituted oxindole derivatives were designed and synthesized as antiproliferative agents. The antiproliferative activity of compounds 6a–j was…”
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New 2-oxoindole derivatives as multiple PDGFRα/ß and VEGFR-2 tyrosine kinase inhibitors by Ezelarab, Hend A.A., Abd El-Hafeez, Amer Ali, Ali, Taha F.S., Sayed, Ahmed M., Hassan, Heba A., Beshr, Eman A.M., Abbas, Samar H.

“…[Display omitted] •Two series based 2-oxoindole derivatives. N-aryl acetamides 6a-o having amide linker and its isoster benzyloxy benzylidenes 9a-p were…”
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Guanidine dicycloamine-based analogs: green chemistry synthesis, biological investigation, and molecular docking studies as promising antibacterial and antiglycation leads by El-Remaily, Mahmoud Abd El Aleem A A, Aboelez, Moustafa O, Ezelarab, Hend A A, Selim, Heba Mohammed Refat M, Taha, Enas A, Mohamed, Shaaban K, Soliman, Ahmed M, Abdallah, Mohamed S, Fawy, Mariam A, Hassany, Mohamed A, Ahmed, Nessar, Alsaggaf, Azhaar T, El Hamd, Mohamed A, Kamel, Moumen S

“…Dicyandiamide (DCD) reacted with amino acids 1a-f to produce biguanides 2 and 4 and guanidine pyrazolones 3, 5, 6, 7, and 8, according to the reaction. DCD…”
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Novel antimicrobial ciprofloxacin-pyridinium quaternary ammonium salts with improved physicochemical properties and DNA gyrase inhibitory activity by Ezelarab, Hend A. A., Abbas, Samar H., Abourehab, Mohammed A. S., Badr, Mohamed, Sureram, Sanya, Hongmanee, Poonpilas, Kittakoop, Prasat, Abuo-Rahma, Gamal El-Din A., Hassan, Heba A.

“…New ciprofloxacin/ quaternary ammonium salts 3a–e were designed and synthesized as potential antimicrobial agents. Most of the prepared derivatives showed…”
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Indole-based FLT3 inhibitors and related scaffolds as potential therapeutic agents for acute myeloid leukemia by Ezelarab, Hend A. A., Ali, Taha F. S., Abbas, Samar H., Hassan, Heba A., Beshr, Eman A. M.

“…Fms-like tyrosine kinase 3 (FLT3) mutation mechanisms are among the most common genetic abnormalities detected in about 30% of acute myeloid leukemia (AML)…”
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