Search Results - "Ezekowitz, Alan B"

Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders by Cisar, Justin S, Weber, Olivia D, Clapper, Jason R, Blankman, Jacqueline L, Henry, Cassandra L, Simon, Gabriel M, Alexander, Jessica P, Jones, Todd K, Ezekowitz, R. Alan B, O’Neill, Gary P, Grice, Cheryl A

“…The serine hydrolase monoacylglycerol lipase (MGLL) converts the endogenous cannabinoid receptor agonist 2-arachidonoylglycerol (2-AG) and other…”
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Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome by Lysenko, Larisa V, Kim, Jeesun, Henry, Cassandra, Tyrtyshnaia, Anna, Kohnz, Rebecca A, Madamba, Francisco, Simon, Gabriel M, Kleschevnikova, Natalia E, Nomura, Daniel K, Ezekowitz, R Alan B, Kleschevnikov, Alexander M

“…Genetic alterations or pharmacological treatments affecting endocannabinoid signaling have profound effects on synaptic and neuronal properties and, under…”
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Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain by Stuart, Lynda M, Deng, Jiusheng, Silver, Jessica M, Takahashi, Kazue, Tseng, Anita A, Hennessy, Elizabeth J, Ezekowitz, R. Alan B, Moore, Kathryn J

“…Phagocyte recognition and clearance of bacteria play essential roles in the host response to infection. In an on-going forward genetic screen, we identify the…”
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Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli by Rämet, Mika, Manfruelli, Pascal, Pearson, Alan, Mathey-Prevot, Bernard, Ezekowitz, R. Alan B

“…The recognition and phagocytosis of microbes by macrophages is a principal aspect of innate immunity that is conserved from insects to humans. Drosophila…”
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The Role of the Mannose-Binding Lectin in Innate Immunity by Takahashi, Kazue, Ezekowitz, R. Alan B.

“…The innate immune system, which includes mannose-binding lectin (MBL), recognizes a broad range of molecular patterns on a broad range of infectious agents and…”
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Activation of the Lectin Pathway by Natural IgM in a Model of Ischemia/Reperfusion Injury by Zhang, Ming, Takahashi, Kazue, Alicot, Elisabeth M, Vorup-Jensen, Thomas, Kessler, Benedikt, Thiel, Steffen, Jensenius, Jens Christian, Ezekowitz, R. Alan B, Moore, Francis D, Carroll, Michael C

“…Reperfusion of ischemic tissues elicits an acute inflammatory response involving serum complement, which is activated by circulating natural IgM specific to…”
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Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila by Franc, N.C, Heitzler, P, Ezekowitz, R.A.B, White, K

“…Macrophages in the Drosophila embryo are responsible for the phagocytosis of apoptotic cells and are competent to engulf bacteria. Croquemort (CRQ) is a…”
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Mannose-binding lectin regulates host resistance and pathology during experimental infection with Trypanosoma cruzi by Rothfuchs, Antonio Gigliotti, Roffê, Ester, Gibson, Amanda, Cheever, Allen W, Ezekowitz, R Alan B, Takahashi, Kazue, Steindel, Mario, Sher, Alan, Báfica, André

“…Mannose-binding lectin (MBL) is a humoral pattern-recognition molecule important for host defense. Although recent genetic studies suggest an involvement of…”
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Reduced tissue damage and improved recovery of motor function after traumatic brain injury in mice deficient in complement component C4 by You, Zerong, Yang, Jinsheng, Takahashi, Kazue, Yager, Phoebe H, Kim, Hyung-Hwan, Qin, Tao, Stahl, Gregory L, Ezekowitz, R Alan B, Carroll, Michael C, Whalen, Michael J

“…Complement component C4 mediates C3-dependent tissue damage after systemic ischemia—reperfusion injury. Activation of C3 also contributes to the pathogenesis…”
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Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome by Ip, W K Eddie, Takahashi, Kazue, Moore, Kathryn J, Stuart, Lynda M, Ezekowitz, R Alan B

“…Innate immunity is the first-line defense against pathogens and relies on phagocytes, soluble components, and cell-surface and cytosolic pattern recognition…”
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Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila by Kocks, Christine, Cho, Ju Hyun, Nehme, Nadine, Ulvila, Johanna, Pearson, Alan M., Meister, Marie, Strom, Charles, Conto, Stephanie L., Hetru, Charles, Stuart, Lynda M., Stehle, Thilo, Hoffmann, Jules A., Reichhart, Jean-Marc, Ferrandon, Dominique, Rämet, Mika, Ezekowitz, R. Alan B.

“…Phagocytosis is a complex, evolutionarily conserved process that plays a central role in host defense against infection. We have identified a predicted…”
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The mannose-binding lectin: a prototypic pattern recognition molecule by Takahashi, Kazue, Ip, WK Eddie, Michelow, Ian C, Ezekowitz, R Alan B

“…The innate immune system is comprised of a sophisticated network of recognition and effector molecules that act together to protect the host in the first…”
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Interferon Alfa-2a Therapy for Life-Threatening Hemangiomas of Infancy by Ezekowitz, R. Alan B, Mulliken, John B, Folkman, Judah

“…HEMANGIOMA of infancy is an angiomatous disorder characterized by the proliferation of capillary endothelium, with multilamination of the basement membrane 1 ,…”
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Deficiency of mannose-binding lectin greatly increases antibody response in a mouse model of vaccination by Guttormsen, Hilde-Kari, Stuart, Lynda M, Shi, Lei, Carroll, Mike C, Chen, Jianzhu, Kasper, Dennis L, Ezekowitz, R. Alan B, Takahashi, Kazue

“…A bstract Mannose-binding lectin (MBL), a pattern recognition innate immune molecule, selectively binds distinct chemical patterns, including carbohydrates…”
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Mannose-Binding Lectin-Deficient Mice Display Defective Apoptotic Cell Clearance but No Autoimmune Phenotype by Stuart, Lynda M, Takahashi, Kazue, Shi, Lei, Savill, John, Ezekowitz, R. Alan B

“…Mannose-binding lectin (MBL) is a circulating serum protein that is sequestered to sites of inflammation and infection. MBL is a member of the collectin family…”
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The mannose receptor is a pattern recognition receptor involved in host defense by Stahl, Philip D, Ezekowitz, R Alan B

“…The mannose receptor recognizes the patterns of carbohydrates that decorate the surfaces and cell walls of infectious agents. This macrophage and dendritic…”
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High-Dose Mannose-Binding Lectin Therapy for Ebola Virus Infection by Michelow, Ian C., Lear, Calli, Scully, Corinne, Prugar, Laura I., Longley, Clifford B., Yantosca, L. Michael, Ji, Xin, Karpel, Marshall, Brudner, Matthew, Takahashi, Kazue, Spear, Gregory T., Ezekowitz, R. Alan B., Schmidt, Emmett V., Olinger, Gene G.

“…Mannose-binding lectin (MBL) targets diverse microorganisms for phagocytosis and complement-mediated lysis by binding specific surface glycans. Although…”
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Relative Roles of Complement Factor 3 and Mannose-Binding Lectin in Host Defense against Infection by Takahashi, Kazue, Shi, Lei, Gowda, Lakshmi D, Ezekowitz, R. Alan B

“…Staphylococcus aureus is a major cause of severe nosocomial and community-acquired infections. Phagocytes and humoral molecules, including complement, have…”
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Mannose-Binding Lectin Is a Regulator of Inflammation That Accompanies Myocardial Ischemia and Reperfusion Injury by Walsh, Mary C, Bourcier, Todd, Takahashi, Kazue, Shi, Lei, Busche, Marc N, Rother, Russell P, Solomon, Scott D, Ezekowitz, R. Alan B, Stahl, Gregory L

“…The mannose-binding lectin (MBL), a circulating pattern recognition molecule, recognizes a wide range of infectious agents with resultant initiation of the…”
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Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity by Cho, Ju Hyun, Fraser, Iain P., Fukase, Koichi, Kusumoto, Shoichi, Fujimoto, Yukari, Stahl, Gregory L., Ezekowitz, R. Alan B.

“…Innate immune responses to bacteria require cooperative interactions between host recognition molecules and phagocytes. The peptidoglycan recognition proteins…”
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