Search Results - "Ezaki, J."

Tripeptidyl Peptidase I, the Late Infantile Neuronal Ceroid Lipofuscinosis Gene Product, Initiates the Lysosomal Degradation of Subunit c of ATP Synthase by Ezaki, Junji, Takeda-Ezaki, Mitsue, Kominami, Eiki

“…The specific accumulation of a hydrophobic protein, subunit c of ATP synthase, in lysosomes from the cells of patients with the late infantile form of NCL…”
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Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice by Komatsu, Masaaki, Waguri, Satoshi, Ueno, Takashi, Iwata, Junichi, Murata, Shigeo, Tanida, Isei, Ezaki, Junji, Mizushima, Noboru, Ohsumi, Yoshinori, Uchiyama, Yasuo, Kominami, Eiki, Tanaka, Keiji, Chiba, Tomoki

“…Autophagy is a membrane-trafficking mechanism that delivers cytoplasmic constituents into the lysosome/vacuole for bulk protein degradation. This mechanism is…”
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Interleukin-11 links oxidative stress and compensatory proliferation by Nishina, Takashi, Komazawa-Sakon, Sachiko, Yanaka, Saeko, Piao, Xuehua, Zheng, Dong-Mei, Piao, Jiang-Hu, Kojima, Yuko, Yamashina, Shunhei, Sano, Emiko, Putoczki, Tracy, Doi, Takahiro, Ueno, Takashi, Ezaki, Junji, Ushio, Hiroko, Ernst, Matthias, Tsumoto, Kouhei, Okumura, Ko, Nakano, Hiroyasu

“…Apoptotic cells can stimulate the compensatory proliferation of surrounding cells to maintain tissue homeostasis. Although oxidative stress is associated with…”
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Decreased lysosomal subunit c-degrading activity in fibroblasts from patients with late infantile neuronal ceroid lipofuscinosis by Ezaki, J, Wolfe, L S, Kominami, E

“…We investigated in in-vitro cell-free incubation experiments which factor, lysosomal proteolytic dysfunction or structural alteration of subunit c, is…”
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New insight into lysosomal protein storage disease : delayed catabolism of ATP synthase subunit c in Batten disease by KOMINAMI, E, EZAKI, J, WOLFE, L. S

“…Subunit c is normally present as an inner mitochondrial membrane component of the Fo sector of the ATP synthase complex, but in the late infantile form of…”
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Effects of Isoflavone and Exercise on BMD and Fat Mass in Postmenopausal Japanese Women: A 1‐Year Randomized Placebo‐Controlled Trial by Wu, Jian, Oka, Jun, Tabata, Izumi, Higuchi, Mitsuru, Toda, Toshiya, Fuku, Noriyuki, Ezaki, Junko, Sugiyama, Fumie, Uchiyama, Shigeto, Yamada, Kazuhiko, Ishimi, Yoshiko

“…The combined intervention of isoflavone intake and walking exercise over 1 year in postmenopausal Japanese women exhibited a trend for a greater effect on…”
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Cathepsin D Deficiency Induces Lysosomal Storage with Ceroid Lipofuscin in Mouse CNS Neurons by Koike, Masato, Nakanishi, Hiroshi, Saftig, Paul, Ezaki, Junji, Isahara, Kyoko, Ohsawa, Yoshiyuki, Schulz-Schaeffer, Walter, Watanabe, Tsuyoshi, Waguri, Satoshi, Kametaka, Satoshi, Shibata, Masahiro, Yamamoto, Kenji, Kominami, Eiki, Peters, Christoph, von Figura, Kurt, Uchiyama, Yasuo

“…Cathepsin D-deficient (CD-/-) mice have been shown to manifest seizures and become blind near the terminal stage [approximately postnatal day (P) 26]. We…”
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Defect of proteolysis of mitochondrial ATP synthase subunit C in neuronal ceroid lipofuscinosis by Ezaki, J, Wolfe, L S, Kominami, E

“…Mechanism of lysosomal storage of mitochondrial ATP synthase subunit c in late infantile form of NCL was studied. Morphological and biochemical examinations…”
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Lysosomal proteinosis based on decreased degradation of a specific protein, mitochondrial ATP synthase subunit C: Batten disease by Ezaki, J, Wolfe, L S, Ishidoh, K, Muno, D, Ueno, T, Kominami, E

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Batten disease (Neuronal ceroid lipofuscinoses)--accumulation of ATP synthase subunit c caused by the delay of lysosomal degradation by Ezaki, J, Kominami, E

“…The neuronal ceroid lipofuscinoses (NCLs) represent a group of recessively inherited neurogenerative diseases of infants, children, and young adults that leads…”
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Reliability in load/unload process of new type slider by Morita, H., Nakamura, A., Ezaki, J.

“…A simple thin film head called the Mellisuga head has been developed. The head has an extremely low flying height (0.03 mu m-0.07 mu m). The reliability in the…”
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Thin film head for quasi-contact head/disk interface by Fukuda, K., Hamanaka, H., Sasaki, A., Ezaki, J.

“…A thin film head with a single, nearly square, flat ABS with adequate edge blend instead of a conventional two-rail taper-flat slider has been developed. The…”
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Molecular basis of lysosomal accumulation of subunit c of mitochondrial ATP synthase in neuronal ceroid‐lipofuscinosis by Ezaki, J., Wolfe, L. S., Kominami, E.

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Effect of the calcium channel blocker nilvadipine on urinary albumin excretion in hypertensive microalbuminuric patients with non-insulin-dependent diabetes mellitus by Sumida, Y, Yano, Y, Murata, K, Goto, H, Ura, H, Ezaki, J, Tsutsumi, S, Shirayama, K, Misaki, M, Shima, T

“…A 24-week study was conducted to evaluate the effects of the dihydropyridine calcium channel blocker nilvadipine on urinary albumin excretion in eight…”
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Urinary transferrin by Misaki, M, Tanaka, T, Ezaki, J, Sumida, Y, Yano, Y

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Excess Peroxisomes Are Degraded by Autophagic Machinery in Mammals by Iwata, Jun-ichi, Ezaki, Junji, Komatsu, Masaaki, Yokota, Sadaki, Ueno, Takashi, Tanida, Isei, Chiba, Tomoki, Tanaka, Keiji, Kominami, Eiki

“…Peroxisomes are degraded by autophagic machinery termed “pexophagy” in yeast; however, whether this is essential for peroxisome degradation in mammals remains…”
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The Intracellular Location and Function Of Proteins Of Neuronal Ceroid Lipofuscinoses by Ezaki, Junji, Kominami, Eiki

“…Neuronal ceroid lipofuscinoses are a group of diseases characterized by accumulation of hydrophobic proteins in lysosomes of neurons and other types of cells…”
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Specific association of increased vascular endothelial growth factor expression and its receptors with macrophage differentiation of HL-60 leukemia cells by Ohsaka, Akimichi, Hirota-Komatsu, Satoko, Shibata, Miki, Ezaki, Junji, Shinohara, Fumikazu, Yoshida, Tetsuo

“…We investigated the gene expression profiles of vascular endothelial growth factor (VEGF) and its receptors in HL-60 leukemia cells. In the VEGF family, both…”
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CLC‐3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis by Yoshikawa, Momono, Uchida, Shinichi, Ezaki, Junji, Rai, Tatemitsu, Hayama, Atsushi, Kobayashi, Katsuki, Kida, Yujiro, Noda, Masaki, Koike, Masato, Uchiyama, Yasuo, Marumo, Fumiaki, Kominami, Eiki, Sasaki, Sei

“…Background: CLC‐3 is a member of the CLC chloride channel family and is widely expressed in mammalian tissues. To determine the physiological role of CLC‐3, we…”
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Characterization of Cln3p, the gene product responsible for juvenile neuronal ceroid lipofuscinosis, as a lysosomal integral membrane glycoprotein by Ezaki, Junji, Takeda‐Ezaki, Mitsue, Koike, Masato, Ohsawa, Yoshiyuki, Taka, Hikari, Mineki, Reiko, Murayama, Kimie, Uchiyama, Yasuo, Ueno, Takashi, Kominami, Eiki

“…Juvenile neuronal ceroid lipofuscinosis (JNCL) is an autosomal recessively inherited lysosomal storage disease involving a mutation in the CLN3 gene. The…”
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