Search Results - "Eykyn, Thomas R"

Intracellular sodium elevation reprograms cardiac metabolism by Aksentijević, Dunja, Karlstaedt, Anja, Basalay, Marina V., O’Brien, Brett A., Sanchez-Tatay, David, Eminaga, Seda, Thakker, Alpesh, Tennant, Daniel A., Fuller, William, Eykyn, Thomas R., Taegtmeyer, Heinrich, Shattock, Michael J.

“…Intracellular Na elevation in the heart is a hallmark of pathologies where both acute and chronic metabolic remodelling occurs. Here, we assess whether acute…”
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MCT1 Inhibitor AZD3965 Increases Mitochondrial Metabolism, Facilitating Combination Therapy and Noninvasive Magnetic Resonance Spectroscopy by Beloueche-Babari, Mounia, Wantuch, Slawomir, Casals Galobart, Teresa, Koniordou, Markella, Parkes, Harold G, Arunan, Vaitha, Chung, Yuen-Li, Eykyn, Thomas R, Smith, Paul D, Leach, Martin O

“…Monocarboxylate transporters (MCT) modulate tumor cell metabolism and offer promising therapeutic targets for cancer treatment. Understanding the impact of MCT…”
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Comparison of macrocyclic and acyclic chelators for gallium-68 radiolabelling by Tsionou, Maria Iris, Knapp, Caroline E, Foley, Calum A, Munteanu, Catherine R, Cakebread, Andrew, Imberti, Cinzia, Eykyn, Thomas R, Young, Jennifer D, Paterson, Brett M, Blower, Philip J, Ma, Michelle T

“…Gallium-68 ( Ga) is a positron-emitting isotope used for clinical PET imaging of peptide receptor expression. Ga radiopharmaceuticals used in molecular PET…”
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Elevated Na is a dynamic and reversible modulator of mitochondrial metabolism in the heart by Chung, Yu Jin, Hoare, Zoe, Baark, Friedrich, Yu, Chak Shun, Guo, Jia, Fuller, William, Southworth, Richard, Katschinski, Doerthe M., Murphy, Michael P., Eykyn, Thomas R., Shattock, Michael J.

“…Elevated intracellular sodium Na i adversely affects mitochondrial metabolism and is a common feature of heart failure. The reversibility of acute Na induced…”
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Cysteine trisulfide oxidizes protein thiols and induces electrophilic stress in human cells by Switzer, Christopher H., Guttzeit, Sebastian, Eykyn, Thomas R., Eaton, Philip

“…The cellular effects of hydrogen sulfide (H2S) signaling may be partially mediated by the formation of alkyl persulfides from thiols, such as glutathione and…”
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Naked mole-rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles by Faulkes, Chris G., Eykyn, Thomas R., Miljkovic, Jan Lj, Gilbert, James D., Charles, Rebecca L., Prag, Hiran A., Patel, Nikayla, Hart, Daniel W., Murphy, Michael P., Bennett, Nigel C., Aksentijevic, Dunja

“…The naked mole-rat Heterocephalus glaber is a eusocial mammal exhibiting extreme longevity (37-year lifespan), extraordinary resistance to hypoxia and absence…”
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Detecting Validated Intracellular ROS Generation with 18F-dihydroethidine-Based PET by Waters, Edward C. T., Baark, Friedrich, Yu, Zilin, Mota, Filipa, Eykyn, Thomas R., Yan, Ran, Southworth, Richard

“…Purpose To determine the sensitivity of the 18 F-radiolabelled dihydroethidine analogue ([ 18 F]DHE) to ROS in a validated ex vivo model of tissue oxidative…”
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Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1 by Kavanagh Williamson, Maia, Coombes, Naomi, Juszczak, Florian, Athanasopoulos, Marios, Khan, Mariam B, Eykyn, Thomas R, Srenathan, Ushani, Taams, Leonie S, Dias Zeidler, Julianna, Da Poian, Andrea T, Huthoff, Hendrik

“…Infection of primary CD4+ T cells with HIV-1 coincides with an increase in glycolysis. We investigated the expression of glucose transporters (GLUT) and…”
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Detection of anthracycline-induced cardiotoxicity using perfusion-corrected 99mTc sestamibi SPECT by Safee, Zaitulhusna M., Baark, Friedrich, Waters, Edward C. T., Veronese, Mattia, Pell, Victoria R., Clark, James E., Mota, Filipa, Livieratos, Lefteris, Eykyn, Thomas R., Blower, Philip J., Southworth, Richard

“…By the time cardiotoxicity-associated cardiac dysfunction is detectable by echocardiography it is often beyond meaningful intervention. 99m Tc-sestamibi is…”
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Tissue acidosis does not mediate the hypoxia selectivity of [64Cu][Cu(ATSM)] in the isolated perfused rat heart by Baark, Friedrich, Shaughnessy, Fiona, Pell, Victoria R., Clark, James E., Eykyn, Thomas R., Blower, Philip, Southworth, Richard

“…Copper-64-Diacetyl-bis(N 4 -methylthiosemicarbazone) [ 64 Cu][Cu(ATSM)] is a hypoxia-targeting PET tracer with applications in oncology and cardiology. Upon…”
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Age-Dependent Decline in Cardiac Function in Guanidinoacetate- N -Methyltransferase Knockout Mice by Aksentijević, Dunja, Zervou, Sevasti, Eykyn, Thomas R, McAndrew, Debra J, Wallis, Julie, Schneider, Jurgen E, Neubauer, Stefan, Lygate, Craig A

“…Guanidinoacetate -methyltransferase (GAMT) is the second essential enzyme in creatine (Cr) biosynthesis. Short-term Cr deficiency is metabolically well…”
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MEK1/2 Inhibition Decreases Lactate in BRAF-Driven Human Cancer Cells by MINIOTIS, Maria Falck, ARUNAN, Vaitha, EYKYN, Thomas R, MARAIS, Richard, WORKMAN, Paul, LEACH, Martin O, BELOUECHE-BABARI, Mounia

“…The RAS/BRAF/MEK/ERK signaling pathway is a central driver in cancer with many BRAF and MEK inhibitors being evaluated in clinical trials. Identifying…”
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Disrupting Na + ion homeostasis and Na + /K + ATPase activity in breast cancer cells directly modulates glycolysis in vitro and in vivo by Michaels, Aidan M, Zoccarato, Anna, Hoare, Zoe, Firth, George, Chung, Yu Jin, Kuchel, Philip W, Shah, Ajay M, Shattock, Michael J, Southworth, Richard, Eykyn, Thomas R

“…Glycolytic flux is regulated by the energy demands of the cell. Upregulated glycolysis in cancer cells may therefore result from increased demand for adenosine…”
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Assessment of hepatic fatty acids during non-alcoholic steatohepatitis progression using magnetic resonance spectroscopy by Xavier, Aline, Zacconi, Flavia, Santana-Romo, Fabián, Eykyn, Thomas R., Lavin, Begoña, Phinikaridou, Alkystis, Botnar, René, Uribe, Sergio, Oyarzún, Juan Esteban, Cabrera, Daniel, Arrese, Marco, Andia, Marcelo E.

“…[Display omitted] Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver abnormalities including steatosis, steatohepatitis, fibrosis, and…”
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Subtle Role for Adenylate Kinase 1 in Maintaining Normal Basal Contractile Function and Metabolism in the Murine Heart by Zervou, Sevasti, McAndrew, Debra J, Whittington, Hannah J, Lake, Hannah A, Park, Kyung Chan, Cha, Kuan Minn, Ostrowski, Philip J, Eykyn, Thomas R, Schneider, Jürgen E, Neubauer, Stefan, Lygate, Craig A

“…Adenylate kinase 1 (AK1) catalyses the reaction 2ADP ↔ ATP + AMP, extracting extra energy under metabolic stress and promoting energetic homeostasis. We…”
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Lactate and choline metabolites detected in vitro by nuclear magnetic resonance spectroscopy are potential metabolic biomarkers for PI3K inhibition in pediatric glioblastoma by Al-Saffar, Nada M S, Marshall, Lynley V, Jackson, L Elizabeth, Balarajah, Geetha, Eykyn, Thomas R, Agliano, Alice, Clarke, Paul A, Jones, Chris, Workman, Paul, Pearson, Andrew D J, Leach, Martin O

“…The phosphoinositide 3-kinase (PI3K) pathway is believed to be of key importance in pediatric glioblastoma. Novel inhibitors of the PI3K pathway are being…”
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Stretch-Induced Ordering of Prochiral Dimethyl Sulfoxide in Anisotropic Hydrogels Analysed by 1H and 2H Nuclear Magnetic Resonance by Elliott, Stuart James, Kuchel, Philip W, Eykyn, Thomas R

“…Nuclear spins in small molecules dissolved in stretched hydrogels typically have population-averaged residual interactions. The nuclear magnetic resonance…”
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NOS2 and S -nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression by Switzer, Christopher H, Cho, Hyun-Ju, Eykyn, Thomas R, Lavender, Paul, Eaton, Philip

“…Inducible nitric oxide synthase (NOS2) produces high local concentrations of nitric oxide (NO), and its expression is associated with inflammation, cellular…”
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Empagliflozin improves cardiac energetics during ischaemia/reperfusion by directly increasing cardiac ketone utilization by Chase, Dylan, Eykyn, Thomas R, Shattock, Michael J, Chung, Yu Jin

“…Abstract Aims Empagliflozin (EMPA), a potent inhibitor of the renal sodium–glucose cotransporter 2 and an effective treatment for Type 2 diabetes, has been…”
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Cardiac metabolomic profile of the naked mole-rat-glycogen to the rescue by Faulkes, Chris G, Eykyn, Thomas R, Aksentijevic, Dunja

“…The African naked mole-rat ( ) is unique among mammals, displaying extreme longevity, resistance to cardiovascular disease and an ability to survive long…”
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