Search Results - "Eyjolfsson, Gudmundur"

A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma by Smith, Dirk, Helgason, Hannes, Sulem, Patrick, Bjornsdottir, Unnur Steina, Lim, Ai Ching, Sveinbjornsson, Gardar, Hasegawa, Haruki, Brown, Michael, Ketchem, Randal R, Gavala, Monica, Garrett, Logan, Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Sigurdsson, Asgeir, Magnusson, Olafur T, Eyjolfsson, Gudmundur I, Olafsson, Isleifur, Onundarson, Pall Torfi, Sigurdardottir, Olof, Gislason, David, Gislason, Thorarinn, Ludviksson, Bjorn Runar, Ludviksdottir, Dora, Boezen, H Marike, Heinzmann, Andrea, Krueger, Marcus, Porsbjerg, Celeste, Ahluwalia, Tarunveer S, Waage, Johannes, Backer, Vibeke, Deichmann, Klaus A, Koppelman, Gerard H, Bønnelykke, Klaus, Bisgaard, Hans, Masson, Gisli, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F, Johnston, James A, Jonsdottir, Ingileif, Stefansson, Kari

“…IL-33 is a tissue-derived cytokine that induces and amplifies eosinophilic inflammation and has emerged as a promising new drug target for asthma and allergic…”
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Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets by Grarup, Niels, Sulem, Patrick, Sandholt, Camilla H, Thorleifsson, Gudmar, Ahluwalia, Tarunveer S, Steinthorsdottir, Valgerdur, Bjarnason, Helgi, Gudbjartsson, Daniel F, Magnusson, Olafur T, Sparsø, Thomas, Albrechtsen, Anders, Kong, Augustine, Masson, Gisli, Tian, Geng, Cao, Hongzhi, Nie, Chao, Kristiansen, Karsten, Husemoen, Lise Lotte, Thuesen, Betina, Li, Yingrui, Nielsen, Rasmus, Linneberg, Allan, Olafsson, Isleifur, Eyjolfsson, Gudmundur I, Jørgensen, Torben, Wang, Jun, Hansen, Torben, Thorsteinsdottir, Unnur, Stefánsson, Kari, Pedersen, Oluf

“…Genome-wide association studies have mainly relied on common HapMap sequence variations. Recently, sequencing approaches have allowed analysis of low frequency…”
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Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis by Olafsdottir, Thorunn A., Theodors, Fannar, Bjarnadottir, Kristbjorg, Bjornsdottir, Unnur Steina, Agustsdottir, Arna B., Stefansson, Olafur A., Ivarsdottir, Erna V., Sigurdsson, Jon K., Benonisdottir, Stefania, Eyjolfsson, Gudmundur I., Gislason, David, Gislason, Thorarinn, Guðmundsdóttir, Steinunn, Gylfason, Arnaldur, Halldorsson, Bjarni V., Halldorsson, Gisli H., Juliusdottir, Thorhildur, Kristinsdottir, Anna M., Ludviksdottir, Dora, Ludviksson, Bjorn R., Masson, Gisli, Norland, Kristjan, Onundarson, Pall T., Olafsson, Isleifur, Sigurdardottir, Olof, Stefansdottir, Lilja, Sveinbjornsson, Gardar, Tragante, Vinicius, Gudbjartsson, Daniel F., Thorleifsson, Gudmar, Sulem, Patrick, Thorsteinsdottir, Unnur, Norddahl, Gudmundur L., Jonsdottir, Ingileif, Stefansson, Kari

“…Asthma is one of the most common chronic diseases affecting both children and adults. We report a genome-wide association meta-analysis of 69,189 cases and…”
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A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis by Kristjansson, Ragnar P., Benonisdottir, Stefania, Davidsson, Olafur B., Oddsson, Asmundur, Tragante, Vinicius, Sigurdsson, Jon K., Stefansdottir, Lilja, Jonsson, Stefan, Jensson, Brynjar O., Arthur, Joseph G., Arnadottir, Gudny A., Sulem, Gerald, Halldorsson, Bjarni V., Gunnarsson, Bjarni, Halldorsson, Gisli H., Stefansson, Olafur A., Oskarsson, Gudjon R., Deaton, Aimee M., Olafsson, Isleifur, Eyjolfsson, Gudmundur I., Sigurdardottir, Olof, Onundarson, Pall T., Gislason, David, Gislason, Thorarinn, Ludviksson, Bjorn R., Ludviksdottir, Dora, Olafsdottir, Thorunn A., Rafnar, Thorunn, Masson, Gisli, Zink, Florian, Bjornsdottir, Gyda, Magnusson, Olafur Th, Bjornsdottir, Unnur S., Thorleifsson, Gudmar, Norddahl, Gudmundur L., Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Jonsdottir, Ingileif, Sulem, Patrick, Stefansson, Kari

“…Nasal polyps (NP) are lesions on the nasal and paranasal sinus mucosa and are a risk factor for chronic rhinosinusitis (CRS). We performed genome-wide…”
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Large-scale whole-genome sequencing of the Icelandic population by Gudbjartsson, Daniel F, Helgason, Hannes, Gudjonsson, Sigurjon A, Zink, Florian, Oddson, Asmundur, Gylfason, Arnaldur, Besenbacher, Soren, Magnusson, Gisli, Halldorsson, Bjarni V, Hjartarson, Eirikur, Sigurdsson, Gunnar Th, Stacey, Simon N, Frigge, Michael L, Holm, Hilma, Saemundsdottir, Jona, Helgadottir, Hafdis Th, Johannsdottir, Hrefna, Sigfusson, Gunnlaugur, Thorgeirsson, Gudmundur, Sverrisson, Jon Th, Gretarsdottir, Solveig, Walters, G Bragi, Rafnar, Thorunn, Thjodleifsson, Bjarni, Bjornsson, Einar S, Olafsson, Sigurdur, Thorarinsdottir, Hildur, Steingrimsdottir, Thora, Gudmundsdottir, Thora S, Theodors, Asgeir, Jonasson, Jon G, Sigurdsson, Asgeir, Bjornsdottir, Gyda, Jonsson, Jon J, Thorarensen, Olafur, Ludvigsson, Petur, Gudbjartsson, Hakon, Eyjolfsson, Gudmundur I, Sigurdardottir, Olof, Olafsson, Isleifur, Arnar, David O, Magnusson, Olafur Th, Kong, Augustine, Masson, Gisli, Thorsteinsdottir, Unnur, Helgason, Agnar, Sulem, Patrick, Stefansson, Kari

“…Kari Stefansson and colleagues report the whole-genome sequencing of 2,636 individuals from Iceland to a median of 20× coverage, providing a valuable genomic…”
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Identification of sequence variants influencing immunoglobulin levels by Jonsson, Stefan, Sveinbjornsson, Gardar, de Lapuente Portilla, Aitzkoa Lopez, Swaminathan, Bhairavi, Plomp, Rosina, Dekkers, Gillian, Ajore, Ram, Ali, Mina, Bentlage, Arthur E H, Elmér, Evelina, Eyjolfsson, Gudmundur I, Gudjonsson, Sigurjon A, Gullberg, Urban, Gylfason, Arnaldur, Halldorsson, Bjarni V, Hansson, Markus, Holm, Hilma, Johansson, Åsa, Johnsson, Ellinor, Jonasdottir, Aslaug, Ludviksson, Bjorn R, Oddsson, Asmundur, Olafsson, Isleifur, Olafsson, Sigurgeir, Sigurdardottir, Olof, Sigurdsson, Asgeir, Stefansdottir, Lilja, Masson, Gisli, Sulem, Patrick, Wuhrer, Manfred, Wihlborg, Anna-Karin, Thorleifsson, Gudmar, Gudbjartsson, Daniel F, Thorsteinsdottir, Unnur, Vidarsson, Gestur, Jonsdottir, Ingileif, Nilsson, Björn, Stefansson, Kari

“…Ingileif Jonsdottir, Björn Nilsson, Kari Stefansson and colleagues perform a genome-wide association study for immunoglobulin levels in Icelandic and Swedish…”
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Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease by Helgadottir, Anna, Gretarsdottir, Solveig, Thorleifsson, Gudmar, Hjartarson, Eirikur, Sigurdsson, Asgeir, Magnusdottir, Audur, Jonasdottir, Aslaug, Kristjansson, Helgi, Sulem, Patrick, Oddsson, Asmundur, Sveinbjornsson, Gardar, Steinthorsdottir, Valgerdur, Rafnar, Thorunn, Masson, Gisli, Jonsdottir, Ingileif, Olafsson, Isleifur, Eyjolfsson, Gudmundur I, Sigurdardottir, Olof, Daneshpour, Maryam S, Khalili, Davood, Azizi, Fereidoun, Swinkels, Dorine W, Kiemeney, Lambertus, Quyyumi, Arshed A, Levey, Allan I, Patel, Riyaz S, Hayek, Salim S, Gudmundsdottir, Ingibjorg J, Thorgeirsson, Gudmundur, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F, Holm, Hilma, Stefansson, Kari

“…Kari Stefansson and colleagues report discovery of 13 variants with large effects on non-HDL cholesterol, LDL cholesterol, HDL cholesterol or triglyceride…”
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Association of variants at UMOD with chronic kidney disease and kidney stones-role of age and comorbid diseases by Gudbjartsson, Daniel F, Holm, Hilma, Indridason, Olafur S, Thorleifsson, Gudmar, Edvardsson, Vidar, Sulem, Patrick, de Vegt, Femmie, d'Ancona, Frank C H, den Heijer, Martin, Wetzels, Jack F M, Franzson, Leifur, Rafnar, Thorunn, Kristjansson, Kristleifur, Bjornsdottir, Unnur S, Eyjolfsson, Gudmundur I, Kiemeney, Lambertus A, Kong, Augustine, Palsson, Runolfur, Thorsteinsdottir, Unnur, Stefansson, Kari

“…Chronic kidney disease (CKD) is a worldwide public health problem that is associated with substantial morbidity and mortality. To search for sequence variants…”
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Common and rare variants associated with kidney stones and biochemical traits by Oddsson, Asmundur, Sulem, Patrick, Helgason, Hannes, Edvardsson, Vidar O., Thorleifsson, Gudmar, Sveinbjörnsson, Gardar, Haraldsdottir, Eik, Eyjolfsson, Gudmundur I., Sigurdardottir, Olof, Olafsson, Isleifur, Masson, Gisli, Holm, Hilma, Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Indridason, Olafur S., Palsson, Runolfur, Stefansson, Kari

“…Kidney stone disease is a complex disorder with a strong genetic component. We conducted a genome-wide association study of 28.3 million sequence variants…”
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Rare SCARB1 mutations associate with high-density lipoprotein cholesterol but not with coronary artery disease by Helgadottir, Anna, Sulem, Patrick, Thorgeirsson, Gudmundur, Gretarsdottir, Solveig, Thorleifsson, Gudmar, Jensson, Brynjar Ö, Arnadottir, Gudny A, Olafsson, Isleifur, Eyjolfsson, Gudmundur I, Sigurdardottir, Olof, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F, Holm, Hilma, Stefansson, Kari

“…Abstract Aims Scavenger receptor Class B Type 1 (SR-BI) is a major receptor for high-density lipoprotein (HDL) that promotes hepatic uptake of cholesterol from…”
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Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA by Gudmundsson, Julius, Sigurdsson, Jon K., Stefansdottir, Lilja, Agnarsson, Bjarni A., Isaksson, Helgi J., Stefansson, Olafur A., Gudjonsson, Sigurjon A., Gudbjartsson, Daniel F., Masson, Gisli, Frigge, Michael L., Stacey, Simon N., Sulem, Patrick, Halldorsson, Gisli H., Tragante, Vinicius, Holm, Hilma, Eyjolfsson, Gudmundur I., Sigurdardottir, Olof, Olafsson, Isleifur, Jonsson, Thorvaldur, Jonsson, Eirikur, Barkardottir, Rosa B., Hilmarsson, Rafn, Asselbergs, Folkert W., Geirsson, Gudmundur, Thorsteinsdottir, Unnur, Rafnar, Thorunn, Thorleifsson, Gudmar, Stefansson, Kari

“…Benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS) are common conditions affecting the majority of elderly males. Here we…”
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Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits by Styrkarsdottir, Unnur, Thorleifsson, Gudmar, Sulem, Patrick, Gudbjartsson, Daniel F., Sigurdsson, Asgeir, Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Oddsson, Asmundur, Helgason, Agnar, Magnusson, Olafur T., Walters, G. Bragi, Frigge, Michael L., Helgadottir, Hafdis T., Johannsdottir, Hrefna, Bergsteinsdottir, Kristin, Ogmundsdottir, Margret H., Center, Jacqueline R., Nguyen, Tuan V., Eisman, John A., Christiansen, Claus, Steingrimsson, Erikur, Jonasson, Jon G., Tryggvadottir, Laufey, Eyjolfsson, Gudmundur I., Theodors, Asgeir, Jonsson, Thorvaldur, Ingvarsson, Thorvaldur, Olafsson, Isleifur, Rafnar, Thorunn, Kong, Augustine, Sigurdsson, Gunnar, Masson, Gisli, Thorsteinsdottir, Unnur, Stefansson, Kari

“…Analysis of whole-genome sequence data of Icelandic individuals has revealed a rare nonsense mutation within the LGR4 gene that is strongly associated with,…”
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Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction by van Rij, Andre M, Gudbjartsson, Daniel F, So, Wing Yee, Williams, Michael J A, Heinzmann, Andrea, Chan, Juliana, Pignatti, Pier Franco, Postma, Dirkje S, Olivieri, Oliviero, Gislason, Thorarinn, Boner, Attilio, Jones, Gregory T, Cheong, Hyun Sub, Ludviksdottir, Dora, Martinelli, Nicola, Malerba, Giovanni, Jonsdottir, Ingileif, Pescollderungg, Lydia, Porsbjerg, Celeste, Shin, Hyoung Doo, Trabetti, Elisabetta, Park, Choon-Sik, Backer, Vibeke, Uh, Soo-Taek, Jönsson, Ulla-Britt, Kong, Augustine, Helgadottir, Anna, James, Alan, Thorsteinsdottir, Unnur, Krueger, Marcus, Boezen, H Marike, Altmuller, Janine, Bjornsdottir, Unnur S, Stefansson, Hreinn, Hall, Ian P, Jonsdottir, Gudrun M, Ma, Ronald, Hansen, Jakob W, Thorleifsson, Gudmar, Rasmussen, Linda M, Palmer, Lyle J, Vaccarino, Viola, Wheatley, Amanda, Granger, Christopher B, Levey, Allan I, Janson, Christer, Quyyumi, Arshed A, Rader, Daniel J, Arnar, David, Reilly, Muredach P, Shah, Svati H, Hui, Jennie, Eyjolfsson, Gudmundur I, Thorgeirsson, Gudmundur, Ludviksson, Bjorn R, Gulcher, Jeffrey, Girelli, Domenico, Ng, Maggie C Y, Wjst, Matthias, Sulem, Patrick, Helgadottir, Hafdis, Deichmann, Klaus, Koppelman, Gerard H, Thompson, Philip J, Jonsdottir, Brynja, Halapi, Eva, Warrington, Nicole M, Werge, Thomas, Stefansson, Kari, Beilby, John, Gislason, David, Williams, Carolyn, Steinthorsdottir, Valgerdur

“…Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the…”
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Common and rare variants associating with serum levels of creatine kinase and lactate dehydrogenase by Kristjansson, Ragnar P., Oddsson, Asmundur, Helgason, Hannes, Sveinbjornsson, Gardar, Arnadottir, Gudny A., Jensson, Brynjar O., Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Bragi Walters, G., Sulem, Gerald, Oskarsdottir, Arna, Benonisdottir, Stefania, Davidsson, Olafur B., Masson, Gisli, Th Magnusson, Olafur, Holm, Hilma, Sigurdardottir, Olof, Jonsdottir, Ingileif, Eyjolfsson, Gudmundur I., Olafsson, Isleifur, Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Sulem, Patrick, Stefansson, Kari

“…Creatine kinase (CK) and lactate dehydrogenase (LDH) are widely used markers of tissue damage. To search for sequence variants influencing serum levels of CK…”
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Discovery of common variants associated with low TSH levels and thyroid cancer risk by Gudmundsson, Julius, Sulem, Patrick, Gudbjartsson, Daniel F, Jonasson, Jon G, Masson, Gisli, He, Huiling, Jonasdottir, Aslaug, Sigurdsson, Asgeir, Stacey, Simon N, Johannsdottir, Hrefna, Th Helgadottir, Hafdis, Li, Wei, Nagy, Rebecca, Ringel, Matthew D, Kloos, Richard T, de Visser, Marieke C H, Plantinga, Theo S, den Heijer, Martin, Aguillo, Esperanza, Panadero, Angeles, Prats, Enrique, Garcia-Castaño, Almudena, De Juan, Ana, Rivera, Fernando, Walters, G Bragi, Bjarnason, Hjordis, Tryggvadottir, Laufey, Eyjolfsson, Gudmundur I, Bjornsdottir, Unnur S, Holm, Hilma, Olafsson, Isleifur, Kristjansson, Kristleifur, Kristvinsson, Hoskuldur, T Magnusson, Olafur, Thorleifsson, Gudmar, Gulcher, Jeffrey R, Kong, Augustine, Kiemeney, Lambertus ALM, Jonsson, Thorvaldur, Hjartarson, Hannes, Mayordomo, Jose I, Netea-Maier, Romana T, de la Chapelle, Albert, Hrafnkelsson, Jon, Thorsteinsdottir, Unnur, Rafnar, Thorunn, Stefansson, Kari

“…Julius Gudmundsson and colleagues report a genome-wide association study for circulating levels of thyroid-stimulating hormone in 27,758 individuals not known…”
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Rare mutations associating with serum creatinine and chronic kidney disease by Sveinbjornsson, Gardar, Mikaelsdottir, Evgenia, Palsson, Runolfur, Indridason, Olafur S, Holm, Hilma, Jonasdottir, Aslaug, Helgason, Agnar, Sigurdsson, Snaevar, Jonasdottir, Adalbjorg, Sigurdsson, Asgeir, Eyjolfsson, Gudmundur Ingi, Sigurdardottir, Olof, Magnusson, Olafur Th, Kong, Augustine, Masson, Gisli, Sulem, Patrick, Olafsson, Isleifur, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F, Stefansson, Kari

“…Chronic kidney disease (CKD) is a complex disorder with a strong genetic component. A number of common sequence variants have been found to associate with…”
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Sequence variants associating with urinary biomarkers by Benonisdottir, Stefania, Kristjansson, Ragnar P, Oddsson, Asmundur, Steinthorsdottir, Valgerdur, Mikaelsdottir, Evgenia, Kehr, Birte, Jensson, Brynjar O, Arnadottir, Gudny A, Sulem, Gerald, Sveinbjornsson, Gardar, Kristmundsdottir, Snaedis, Ivarsdottir, Erna V, Tragante, Vinicius, Gunnarsson, Bjarni, Runolfsdottir, Hrafnhildur Linnet, Arthur, Joseph G, Deaton, Aimee M, Eyjolfsson, Gudmundur I, Davidsson, Olafur B, Asselbergs, Folkert W, Hreidarsson, Astradur B, Rafnar, Thorunn, Thorleifsson, Gudmar, Edvardsson, Vidar, Sigurdsson, Gunnar, Helgadottir, Anna, Halldorsson, Bjarni V, Masson, Gisli, Holm, Hilma, Onundarson, Pall T, Indridason, Olafur S, Benediktsson, Rafn, Palsson, Runolfur, Gudbjartsson, Daniel F, Olafsson, Isleifur, Thorsteinsdottir, Unnur, Sulem, Patrick, Stefansson, Kari

“…Abstract Urine dipstick tests are widely used in routine medical care to diagnose kidney and urinary tract and metabolic diseases. Several environmental…”
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Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma by Swaminathan, Bhairavi, Thorleifsson, Guðmar, Jöud, Magnus, Ali, Mina, Johnsson, Ellinor, Ajore, Ram, Sulem, Patrick, Halvarsson, Britt-Marie, Eyjolfsson, Guðmundur, Haraldsdottir, Vilhelmina, Hultman, Christina, Ingelsson, Erik, Kristinsson, Sigurður Y., Kähler, Anna K., Lenhoff, Stig, Masson, Gisli, Mellqvist, Ulf-Henrik, Månsson, Robert, Nelander, Sven, Olafsson, Isleifur, Sigurðardottir, Olof, Steingrimsdóttir, Hlif, Vangsted, Annette, Vogel, Ulla, Waage, Anders, Nahi, Hareth, Gudbjartsson, Daniel F., Rafnar, Thorunn, Turesson, Ingemar, Gullberg, Urban, Stefánsson, Kári, Hansson, Markus, Thorsteinsdóttir, Unnur, Nilsson, Björn

“…Multiple myeloma (MM) is characterized by an uninhibited, clonal growth of plasma cells. While first-degree relatives of patients with MM show an increased…”
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Identification of low-frequency variants associated with gout and serum uric acid levels by Sulem, Patrick, Stefansson, Kari, Gudbjartsson, Daniel F, Walters, G Bragi, Helgadottir, Hafdis T, Helgason, Agnar, Gudjonsson, Sigurjon A, Zanon, Carlo, Besenbacher, Soren, Bjornsdottir, Gyda, Magnusson, Olafur T, Magnusson, Gisli, Hjartarson, Eirikur, Saemundsdottir, Jona, Gylfason, Arnaldur, Jonasdottir, Adalbjorg, Holm, Hilma, Karason, Ari, Rafnar, Thorunn, Stefansson, Hreinn, Andreassen, Ole A, Pedersen, Jesper H, Pack, Allan I, de Visser, Marieke C H, Kiemeney, Lambertus A, Geirsson, Arni J, Eyjolfsson, Gudmundur I, Olafsson, Isleifur, Kong, Augustine, Masson, Gisli, Jonsson, Helgi, Thorsteinsdottir, Unnur, Jonsdottir, Ingileif

“…We tested 16 million SNPs, identified through whole-genome sequencing of 457 Icelanders, for association with gout and serum uric acid levels. Genotypes were…”
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Lipoprotein(a) Concentration and Risks of Cardiovascular Disease and Diabetes by Gudbjartsson, Daniel F., Thorgeirsson, Gudmundur, Sulem, Patrick, Helgadottir, Anna, Gylfason, Arnaldur, Saemundsdottir, Jona, Bjornsson, Eythor, Norddahl, Gudmundur L., Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Eggertsson, Hannes P., Gretarsdottir, Solveig, Thorleifsson, Gudmar, Indridason, Olafur S., Palsson, Runolfur, Jonasson, Fridbert, Jonsdottir, Ingileif, Eyjolfsson, Gudmundur I., Sigurdardottir, Olof, Olafsson, Isleifur, Danielsen, Ragnar, Matthiasson, Stefan E., Kristmundsdottir, Snaedis, Halldorsson, Bjarni V., Hreidarsson, Astradur B., Valdimarsson, Einar M., Gudnason, Thorarinn, Benediktsson, Rafn, Steinthorsdottir, Valgerdur, Thorsteinsdottir, Unnur, Holm, Hilma, Stefansson, Kari

“…Lipoprotein(a) [Lp(a)] is a causal risk factor for cardiovascular diseases that has no established therapy. The attribute of Lp(a) that affects cardiovascular…”
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