Search Results - "Eyer, Peter"

Management of acute organophosphorus pesticide poisoning by Eddleston, Michael, Buckley, Nick A, MD, Eyer, Peter, Prof, Dawson, Andrew H, Prof

“…Summary Organophosphorus pesticide self-poisoning is an important clinical problem in rural regions of the developing world, and kills an estimated 200 000…”
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Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes by Worek, Franz, Thiermann, Horst, Szinicz, Ladislaus, Eyer, Peter

“…The wide-spread use of organophosphorus compounds (OP) as pesticides and the availability of highly toxic OP-type chemical warfare agents (nerve agents)…”
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The role of oximes in the management of organophosphorus pesticide poisoning by EYER, Peter

“…The number of intoxications with organophosphorus pesticides (OPs) is estimated at some 3,000,000 per year, and the number of deaths and casualties some…”
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Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial by Eddleston, Michael, Eyer, Peter, Worek, Franz, Juszczak, Edmund, Alder, Nicola, Mohamed, Fahim, Senarathna, Lalith, Hittarage, Ariyasena, Azher, Shifa, Jeganathan, K, Jayamanne, Shaluka, von Meyer, Ludwig, Dawson, Andrew H, Sheriff, Mohamed Hussain Rezvi, Buckley, Nick A

“…Poisoning with organophosphorus (OP) insecticides is a major global public health problem, causing an estimated 200,000 deaths each year. Although the World…”
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Molar absorption coefficients for the reduced Ellman reagent: reassessment by Eyer, Peter, Worek, Franz, Kiderlen, Daniela, Sinko, Goran, Stuglin, Anita, Simeon-Rudolf, Vera, Reiner, Elsa

“…The Ellman method for assaying thiols is based on the reaction of thiols with the chromogenic DTNB (5,5 ′-dithiobis-2-nitrobenzoate) whereby formation of the…”
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Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study by Eddleston, Michael, Eyer, Peter, Worek, Franz, Mohamed, Fahim, Senarathna, Lalith, von Meyer, Ludwig, Juszczak, Edmund, Hittarage, Ariyasena, Azhar, Shifa, Dissanayake, Wasantha, Sheriff, MH Rezvi, Szinicz, Ladislaus, Dawson, Andrew H, Buckley, Nick A

“…Although more than 100 organophosphorus insecticides exist, organophosphorus poisoning is usually regarded as a single entity, distinguished only by the…”
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Evaluation of the Test-mate ChE (Cholinesterase) Field Kit in Acute Organophosphorus Poisoning by Rajapakse, Bishan N., MBChB, Thiermann, Horst, MD, Eyer, Peter, MD, Worek, Franz, MD, PhD, Bowe, Steven J., M Med Stat, PhD, Dawson, Andrew H., MBBS, FRACP, Buckley, Nicholas A., MD, FRACP

“…Study objective Measurement of acetylcholinesterase (AChE) is recommended in the management of organophosphorus poisoning, which results in 200,000 deaths…”
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Ninth Pharmacologic-Historical Forum, 2024, Munich, Germany: the development of experimental pharmacology in Munich at the Walther Straub Institute by Eyer, Peter

“…In 1887, Hermann Tappeiner (1847-1927) was appointed as professor for medicinal chemistry and pharmacology. He studied the role of intestinal bacteria and…”
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Paradox findings may challenge orthodox reasoning in acute organophosphate poisoning by Eyer, Peter, Worek, Franz, Thiermann, Horst, Eddleston, Michael

“…It is generally accepted that inhibition of acetylcholinesterase (AChE) is the most important acute toxic action of organophosphorus compounds, leading to…”
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Testing of antidotes for organophosphorus compounds: Experimental procedures and clinical reality by Eyer, Peter, Szinicz, Ladislaus, Thiermann, Horst, Worek, Franz, Zilker, Thomas

“…Abstract According to current knowledge, inhibition of acetylcholinesterase (AChE) is a very important toxic action of organphosphorus compounds (OP). Hence,…”
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Determination of acetylcholinesterase activity by the Ellman assay: A versatile tool for in vitro research on medical countermeasures against organophosphate poisoning by Worek, Franz, Eyer, Peter, Thiermann, Horst

“…ABSTRACT Inhibition of acetylcholinesterase (AChE) is the main mechanism of action of organophosphorus compounds (OP), and AChE reactivators (oximes) are at…”
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Effects of superoxide dismutase on the autoxidation of 1,4-hydroquinone by Eyer, P

“…During autoxidation of 1,4-hydroquinone (H2Q, less than 1 mM) at pH 7.4 and 37 degrees C, stoichiometric amounts of 1,4-benzoquinone (Q) and hydrogen peroxide…”
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Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase by Worek, Franz, Aurbek, Nadine, Wille, Timo, Eyer, Peter, Thiermann, Horst

“…Previous in vitro studies showed marked species differences in the reactivating efficiency of oximes between human and animal acetylcholinesterase (AChE)…”
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In memory of Elsa Reiner by Eyer, Peter, Szinicz, Ladislaus

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Pralidoxime for organophosphate poisoning by Eyer, Peter, Buckley, Nicholas

“…An affordable pralidoxime preparation should be part of a public-health response to the considerable problem of pesticide poisoning in developing countries.8.9…”
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In memory of Ilse Hagedorn by Eyer, Peter

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Reactivation of organophosphate-inhibited human, Cynomolgus monkey, swine and guinea pig acetylcholinesterase by MMB-4: A modified kinetic approach by Worek, Franz, Wille, Timo, Aurbek, Nadine, Eyer, Peter, Thiermann, Horst

“…Treatment of poisoning by highly toxic organophosphorus compounds (OP, nerve agents) is a continuous challenge. Standard treatment with atropine and a…”
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Evaluation of the micromethod for determination of glutathione using enzymatic cycling and Ellman's reagent by Eyer, P, Podhradský, D

“…Evaluation of the kinetic parameters of the various reactions involved in the determination of glutathione provided the rationale for a modification of the…”
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Muscle force and acetylcholinesterase activity in mouse hemidiaphragms exposed to paraoxon and treated by oximes in vitro by Thiermann, Horst, Eyer, Peter, Worek, Franz

“…Abstract The therapy of organophosphorus compound (OP) poisoning is still a challenge to clinical toxicologists. To alleviate peripheral respiratory failure…”
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Is this the epitaph for multiple-dose activated charcoal? by Eyer, Peter, Eyer, Florian

“…In today's Lancet, Michael Eddleston and colleagues1 report a large randomised trial on the efficacy of activated charcoal in self-poisoned patients in rural…”
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