Search Results - "Eyasu Makonnen"

Efforts Made to Eliminate Drug-Resistant Malaria and Its Challenges by Amelo, Wote, Makonnen, Eyasu

“…Since 2000, a good deal of progress has been made in malaria control. However, there is still an unacceptably high burden of the disease and numerous…”
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In vivo antiplasmodial activity and toxicological assessment of hydroethanolic crude extract of Ajuga remota by Nardos, Aschalew, Makonnen, Eyasu

“…Malaria is one of the most life-threatening health problems worldwide and treatment has been compromised by drug resistance. Identifying lead molecules from…”
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Efficacy of dihydroartemisinin-piperaquine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria among children in Africa: a systematic review and meta-analysis of randomized control trials by Assefa, Dawit Getachew, Yismaw, Gizachew, Makonnen, Eyasu

“…Background Emergence of Plasmodium falciparum resistance to artemisinin and its derivatives poses a threat to the global effort to control malaria. The…”
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Antimicrobial prescription patterns in East Africa: a systematic review by Acam, Joan, Kuodi, Paul, Medhin, Girmay, Makonnen, Eyasu

“…Antimicrobial resistance is currently a recognized global health problem stemming from poor antibiotic stewardship by health workers and inappropriate…”
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PA-288 Study coordinator training programs should give attention to particular clinical trial knowledge and skill domains for a holistic set by Ejigu, Dawit, Fekadu, Abebaw, Makonnen, Eyasu

“…BackgroundClinical trial knowledge and skills significantly influence the quality of clinical trial conduct. This article assesses the confidence of the…”
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Comparative effect of dihydroartemisinin-piperaquine and artemether-lumefantrine on gametocyte clearance and haemoglobin recovery in children with uncomplicated Plasmodium falciparum malaria in Africa: a systematic review and meta-analysis of randomized control trials by Assefa, Dawit Getachew, Yismaw, Gizachew, Makonnen, Eyasu

“…•No significant difference in gametocyte clearance was found between dihydroartemisinin-piperaquine (DHA-PQ) and artemether-lumefantrine (AL).•DHA-PQ had a…”
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N-Acetyltransferase-2 (NAT2) phenotype is influenced by genotype-environment interaction in Ethiopians by Aklillu, Eleni, Carrillo, Juan Antonio, Makonnen, Eyasu, Bertilsson, Leif, Djordjevic, Natasa

“…Background and objectives N-acetyltransferase 2 (NAT2) metabolize several drugs including isoniazid. We investigated the effect of genotype, geographical…”
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Effect of 70% Ethanol Extract and its Solvent Fractions of Artemisia afra (Jacq. Ex Willd.) against Pentylenetetrazole-Induced Seizure in Mice by Kediso, Teketel Eristu, Tolessa, Tesfaye, Getachew, Fikirte, Makonnen, Eyasu, Seifu, Daniel

“…Introduction. Artemisia afra (Jacq. ex Willd.), commonly called African wormwood, is a highly aromatic perennial herb and a well-known medicinal plant, claimed…”
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Correlation of N-acetyltransferase 2 genotype and acetylation status with plasma isoniazid concentration and its metabolic ratio in ethiopian tuberculosis patients by Sileshi, Tesemma, Telele, Nigus Fikrie, Burkley, Victoria, Makonnen, Eyasu, Aklillu, Eleni

“…Unfavorable treatment outcomes for tuberculosis (TB) treatment might result from altered plasma exposure to antitubercular drugs in TB patients. The present…”
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Early or deferred initiation of efavirenz during rifampicin‐based TB therapy has no significant effect on CYP3A induction in TB‐HIV infected patients by Aklillu, Eleni, Zumla, Alimuddin, Habtewold, Abiy, Amogne, Wondwossen, Makonnen, Eyasu, Yimer, Getnet, Burhenne, Jürgen, Diczfalusy, Ulf

“…Background and Purpose In TB‐HIV co‐infection, prompt initiation of TB therapy is recommended but anti‐retroviral treatment (ART) is often delayed due to…”
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Antibacterial activity of methanol extracts of the leaves of three medicinal plants against selected bacteria isolated from wounds of lymphoedema patients by Nigussie, Dereje, Davey, Gail, Legesse, Belete Adefris, Fekadu, Abebaw, Makonnen, Eyasu

“…Patients with lymphoedema are at high risk of getting bacterial and fungal wound infections leading to acute inflammatory episodes associated with cellulitis…”
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Characteristics of recent clinical investigations into systemic therapy against cervical cancer: systematic analysis of trial details from Clinicaltrials.gov by Girma, Biniyam, Makonnen, Eyasu, Shibeshi, Workineh

“…A review that systematically assessed the current state of clinical research into systematic therapy-based interventions against invasive cervical cancer. It…”
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Efficacy and safety of azithromycin and amoxicillin/clavulanate for otitis media in children: a systematic review and meta-analysis of randomized controlled trials by Dawit, Gabriel, Mequanent, Solomon, Makonnen, Eyasu

“…Resistance, prolonged therapy, and more adverse reactions made amoxicillin less preferred for treating otitis media. This study aimed to compare the efficacy…”
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Constitutive androstane receptor and pregnane X receptor genotype influence efavirenz plasma concentration and CYP2B6 enzyme activity by Petros, Zelalem, Habtewold, Abiy, Makonnen, Eyasu, Aklillu, Eleni

“…Efavirenz is metabolized by CYP2B6, an inducible enzyme whose expression is regulated by the constitutive androstane receptor and pregnane X receptor nuclear…”
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The safety of a dolutegravir (DTG)-based antiretroviral treatment (ART) regimen for pregnancy and birth outcomes in Ethiopia: evidence from multicenter cohort study by Gedefaw, Abel, Tadesse, Birkneh Tilahun, Berhan, Yifru, Makonnen, Eyasu, Vella, Stefano, Aklillu, Eleni

“…A dolutegravir (DTG)-based antiretroviral regimen has been rolled out for pregnant women in low- and middle-income countries since 2020. However, available…”
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Essential oils as topical anti-infective agents: A systematic review and meta-analysis by Deyno, Serawit, Mtewa, Andrew G., Abebe, Abiy, Hymete, Ariya, Makonnen, Eyasu, Bazira, Joel, Alele, Paul E.

“…•Eighteen clinical trials investigated essential oil effectiveness as topical anti-infective•Essential oils significantly lowered level of new MRSA emergence…”
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Hepatoprotective Effects of Crude Stem Bark Extracts and Solvent Fractions of Cordia africana against Acetaminophen-Induced Liver Injury in Rats by Geresu, Gudeta Duga, Umer, Shemsu, Arayaselassie, Mahlet, Ashebir, Genet, Makonnen, Eyasu

“…Cordia africana Lam (Boraginaceae) is widely used in Ethiopian folk medicine for the treatment of different types of liver disorders. Thus, this study aimed to…”
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Safety of equine tetanus antitoxin for prophylactic use in Ethiopia: a retrospective multi-center study by Joseph, Michele, Woldeamanuel, Yimtubeznash, Medhin, Girmay, Manyazewal, Tsegahun, Fekadu, Abebaw, Makonnen, Eyasu

“…Tetanus remains a severe life-threatening infectious disease and neurological disorder in many parts of the world, where immunization programs are suboptimal…”
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CYP2C19 and CYP2J2 genotypes predict praziquantel plasma exposure among Ethiopian school-aged children by Gebreyesus, Tigist Dires, Makonnen, Eyasu, Telele, Nigus Fikrie, Barry, Abbie, Mnkugwe, Rajabu Hussein, Gerba, Heran, Dahl, Marja-Liisa, Aklillu, Eleni

“…Metabolism of praziquantel (PZQ), a racemic mixture and the only drug approved to treat S. mansoni infection, is mediated by genetically polymorphic enzymes…”
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The Impact of First-Line Anti-Tubercular Drugs' Pharmacokinetics on Treatment Outcome: A Systematic Review by Sileshi, Tesemma, Tadesse, Esayas, Makonnen, Eyasu, Aklillu, Eleni

“…Tuberculosis remains the major public health problem besides tremendous efforts to combat it. Most tuberculosis patients are treated with a standard dose of…”
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