Search Results - "Experimental cell research"

Cell-free therapy based on adipose tissue stem cell-derived exosomes promotes wound healing via the PI3K/Akt signaling pathway by Zhang, Wei, Bai, Xiaozhi, Zhao, Bin, Li, Yan, Zhang, Yijie, Li, Zhenzhen, Wang, Xujie, Luo, Liang, Han, Fu, Zhang, Julei, Han, Shichao, Cai, Weixia, Su, Linlin, Tao, Ke, Shi, Jihong, Hu, Dahai

“…Adipose tissue-derived stem cells (ADSCs) have been shown to enhance wound healing via their paracrine function. Exosomes, as one of the most important…”
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Exosomal miRNA-106b from cancer-associated fibroblast promotes gemcitabine resistance in pancreatic cancer by Fang, Yuan, Zhou, Wentao, Rong, Yefei, Kuang, Tiantao, Xu, Xuefeng, Wu, Wenchuan, Wang, Dansong, Lou, Wenhui

“…Gemcitabine (GEM)-based chemotherapy is commonly used to treat pancreatic cancer. However, acquired resistance to GEM remains a challenge in pancreatic cancer…”
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Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction by Dupont, Sirio

“…Signalling from the extracellular matrix (ECM) is a fundamental cellular input that sustains proliferation, opposes cell death and regulates differentiation…”
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Interplay between tight junctions & adherens junctions by Campbell, Hannah K., Maiers, Jessica L., DeMali, Kris A.

“…Cell-cell adhesions are critical for the development and maintenance of tissues. Present at sites of cell-cell contact are the adherens junctions and tight…”
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Focal adhesions, stress fibers and mechanical tension by Burridge, Keith, Guilluy, Christophe

“…Stress fibers and focal adhesions are complex protein arrays that produce, transmit and sense mechanical tension. Evidence accumulated over many years led to…”
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Upregulation of PD-L1 by SPP1 mediates macrophage polarization and facilitates immune escape in lung adenocarcinoma by Zhang, Yan, Du, Weiwei, Chen, Zhaoliang, Xiang, Cheng

“…Tumor-associated macrophages (TAMs) polarization represents a key regulatory process of tumor progression. However, the underlying mechanisms are unclear. This…”
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NETs promote ALI/ARDS inflammation by regulating alveolar macrophage polarization by Song, Chao, Li, Haitao, Li, Yi, Dai, Minhui, Zhang, Lemeng, Liu, Shuai, Tan, Hongyi, Deng, Pengbo, Liu, Jingjing, Mao, Zhi, Li, Qian, Su, Xiaoli, Long, Yuan, Lin, Fengyu, Zeng, Yanjun, Fan, Yifei, Luo, Bailing, Hu, Chengping, Pan, Pinhua

“…Neutrophils activated during acute lung injury (ALI) form neutrophil extracellular traps (NETs) to capture pathogens. However, excessive NETs can cause severe…”
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TRIM46 contributes to high glucose-induced ferroptosis and cell growth inhibition in human retinal capillary endothelial cells by facilitating GPX4 ubiquitination by Zhang, Jingfa, Qiu, Qinghua, Wang, Haiyan, Chen, Chong, Luo, Dawei

“…Increased permeability of retinal capillary endothelial cells is a key feature in the progression of diabetic retinopathy (DR). Precisely why and how diabetes…”
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Liver ‘organ on a chip’ by Beckwitt, Colin H., Clark, Amanda M., Wheeler, Sarah, Taylor, D. Lansing, Stolz, Donna B., Griffith, Linda, Wells, Alan

“…The liver plays critical roles in both homeostasis and pathology. It is the major site of drug metabolism in the body and, as such, a common target for…”
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Breast cancer-derived exosomes regulate cell invasion and metastasis in breast cancer via miR-146a to activate cancer associated fibroblasts in tumor microenvironment by Yang, Shan-Shan, Ma, Shuang, Dou, He, Liu, Feng, Zhang, Shi-Yuan, Jiang, Cong, Xiao, Min, Huang, Yuan-Xi

“…To explore the effects of breast cancer (BC)-derived exosomes on invasion and migration of BC cells. Exosomes (Exo-MA, Exo-M7, Exo-M1) were extracted from…”
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Mesenchymal stem cell exosomes promote immunosuppression of regulatory T cells in asthma by Du, Yu-mo, Zhuansun, Yong-xun, Chen, Rui, Lin, Lin, Lin, Ying, Li, Jian-guo

“…Mesenchymal stem cells (MSCs) and regulatory T cells (Tregs) are both potent immune-modulators. The aberrant proliferation and function of Tregs plays an…”
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A central role for cadherin signaling in cancer by Kourtidis, Antonis, Lu, Ruifeng, Pence, Lindy J., Anastasiadis, Panos Z.

“…Cadherins are homophilic adhesion molecules with important functions in cell-cell adhesion, tissue morphogenesis, and cancer. In epithelial cells, E-cadherin…”
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Endothelial cell-cell adhesion and signaling by Cerutti, Camilla, Ridley, Anne J.

“…Endothelial cells line blood vessels and provide a dynamic interface between the blood and tissues. They remodel to allow leukocytes, fluid and small molecules…”
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What makes a centromere? by Talbert, Paul B., Henikoff, Steven

“…Centromeres are the eukaryotic chromosomal sites at which the kinetochore forms and attaches to spindle microtubules to orchestrate chromosomal segregation in…”
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Mechanical regulation of myofibroblast phenoconversion and collagen contraction by Hinz, Boris, McCulloch, Christopher A., Coelho, Nuno M.

“…Activated fibroblasts promote physiological wound repair following tissue injury. However, dysregulation of fibroblast activation contributes to the…”
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CXCL12/CXCR4 pathway orchestrates CSC-like properties by CAF recruited tumor associated macrophage in OSCC by Li, Xing, Bu, Wenhuan, Meng, Lin, Liu, Xinchen, Wang, Shuangshuang, Jiang, Liming, Ren, Meisi, Fan, Yu, Sun, Hongchen

“…Tumor-associated macrophage (TAM), a crucial component of immune cell infiltrated in tumor microenvironment, is associated with progression of oral squamous…”
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Exosomes derived from microRNA-30b-3p-overexpressing mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting SAA3 by Yi, Xiaomeng, Wei, Xuxia, Lv, Haijin, An, Yuling, Li, Lijuan, Lu, Pinglan, Yang, Yang, Zhang, Qi, Yi, Huimin, Chen, Guihua

“…Mesenchymal stem cells (MSCs) have been widely documented for their potential role in the treatment of various clinical disorders, including acute lung injury…”
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Lactic acid promotes macrophage polarization through MCT-HIF1α signaling in gastric cancer by Zhang, Lan, Li, Shengmian

“…Reprogramming of energy metabolism and evading immune are two emerging hallmarks of cancers. Accumulating evidence suggest that reprogrammed energy metabolism…”
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Platelet rich plasma (PRP) induces chondroprotection via increasing autophagy, anti-inflammatory markers, and decreasing apoptosis in human osteoarthritic cartilage by Moussa, Mayssam, Lajeunesse, Daniel, Hilal, George, El Atat, Oula, Haykal, Gaby, Serhal, Rim, Chalhoub, Antonio, Khalil, Charbel, Alaaeddine, Nada

“…Autophagy constitutes a defense mechanism to overcome aging and apoptosis in osteoarthritic cartilage. Several cytokines and transcription factors are linked…”
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Astrocyte-derived exosomes suppress autophagy and ameliorate neuronal damage in experimental ischemic stroke by Pei, Xiaoxi, Li, Yucheng, Zhu, Liangfu, Zhou, Zhilong

“…The aim of this study was to investigate the role of astrocyte-derived exosomes (AS-Exo) on neuronal damage in ischemic stroke. We isolated astrocytes from 3-…”
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