Search Results - "Exley, Mark A"

Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production by Lynch, Lydia, Nowak, Michael, Varghese, Bindu, Clark, Justice, Hogan, Andrew E., Toxavidis, Vasillis, Balk, Steven P., O’Shea, Donal, O’Farrelly, Cliona, Exley, Mark A.

“…Invariant natural killer T (iNKT) cells are evolutionarily conserved innate T cells that influence inflammatory responses. We have shown that iNKT cells,…”
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Interplay between the immune system and adipose tissue in obesity by Exley, Mark A, Hand, Laura, O'Shea, Donal, Lynch, Lydia

“…Obesity is a major risk factor for metabolic disease, with white adipose tissue (WAT) inflammation emerging as a key underlying pathology. Alongside its major…”
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Novel Approaches to Exploiting Invariant NKT Cells in Cancer Immunotherapy by Wolf, Benjamin J, Choi, Jiyoung Elizabeth, Exley, Mark A

“…iNKT cells are a subset of innate-like T cells that utilize an invariant TCR alpha chain complexed with a limited repertoire of TCR beta chains to recognize…”
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Adoptive Transfer of Invariant NKT Cells as Immunotherapy for Advanced Melanoma: A Phase I Clinical Trial by Exley, Mark A, Friedlander, Phillip, Alatrakchi, Nadia, Vriend, Lianne, Yue, Simon, Sasada, Tetsuro, Zeng, Wanyong, Mizukami, Yo, Clark, Justice, Nemer, David, LeClair, Kenneth, Canning, Christine, Daley, Heather, Dranoff, Glenn, Giobbie-Hurder, Anita, Hodi, F Stephen, Ritz, Jerome, Balk, Steven P

“…Invariant NKT cells (iNKT) are innate-like CD1d-restricted T cells with immunoregulatory activity in diseases including cancer. iNKT from advanced cancer…”
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What Makes MAITs Wait? by Exley, Mark A.

“…Mucosal-associated invariant T (MAIT) cells recognize microbial non-peptidic antigens presented by non-classical MHC MR1. In this issue of Immunity, Gherardin…”
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A phase 1/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome by Hammond, Terese C., Purbhoo, Marco A., Kadel, Sapana, Ritz, Jerome, Nikiforow, Sarah, Daley, Heather, Shaw, Kit, van Besien, Koen, Gomez-Arteaga, Alexandra, Stevens, Don, Ortuzar, Waldo, Michelet, Xavier, Smith, Rachel, Moskowitz, Darrian, Masakayan, Reed, Yigit, Burcu, Boi, Shannon, Soh, Kah Teong, Chamberland, John, Song, Xin, Qin, Yu, Mishchenko, Ilya, Kirby, Maurice, Nasonenko, Valeriia, Buffa, Alexa, Buell, Jennifer S., Chand, Dhan, van Dijk, Marc, Stebbing, Justin, Exley, Mark A.

“…Invariant natural killer T (iNKT) cells, a unique T cell population, lend themselves for use as adoptive therapy due to diverse roles in orchestrating immune…”
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Positive & Negative Roles of Innate Effector Cells in Controlling Cancer Progression by Stolk, Dorian, van der Vliet, Hans J, de Gruijl, Tanja D, van Kooyk, Yvette, Exley, Mark A

“…Innate immune cells are active at the front line of host defense against pathogens and now appear to play a range of roles under non-infectious conditions as…”
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A2aR adenosine receptor controls cytokine production in iNKT cells by Nowak, Michael, Lynch, Lydia, Yue, Simon, Ohta, Akio, Sitkovsky, Michail, Balk, Steven P, Exley, Mark.A

“…The purine nucleoside adenosine is an important anti-inflammatory molecule, inhibiting a variety of immune cells by adenosine receptor-mediated mechanisms…”
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A biologic-device combination product delivering tumor-derived antigens elicits immunogenic cell death-associated immune responses against glioblastoma by Cultrara, Christopher, Uhl, Christopher, Kirby, Kenneth, Abed Elrazaq, Essam, Zellander, Amelia, Andrews, David W, Scott, Charles B, Galluzzi, Lorenzo, Exley, Mark A, Zilberberg, Jenny

“…IGV-001 is a personalized, autologous cancer cell-based immunotherapy conceived to deliver a tumor-derived antigenic payload in the context of…”
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IAP Antagonists Enhance Cytokine Production from Mouse and Human iNKT Cells by Clancy-Thompson, Eleanor, Ali, Lestat, Bruck, Patrick T, Exley, Mark A, Blumberg, Richard S, Dranoff, Glenn, Dougan, Michael, Dougan, Stephanie K

“…Inhibitor of apoptosis protein (IAP) antagonists are in clinical trials for a variety of cancers, and mouse models show synergism between IAP antagonists and…”
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Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals by Speak, Anneliese O, Salio, Mariolina, Neville, David C.A, Fontaine, Josette, Priestman, David A, Platt, Nick, Heare, Tanya, Butters, Terry D, Dwek, Raymond A, Trottein, Francois, Exley, Mark A, Cerundolo, Vincenzo, Platt, Frances M

“…Development of invariant natural killer T (iNKT) cells requires the presentation of lipid ligand(s) by CD1d molecules in the thymus. The glycosphingolipid…”
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Defective NKT cell activation by CD1d+ TRAMP prostate tumor cells is corrected by interleukin-12 with α-galactosylceramide by Nowak, Michael, Arredouani, Mohammed S, Tun-Kyi, Adrian, Schmidt-Wolf, Ingo, Sanda, Martin G, Balk, Steven P, Exley, Mark A

“…Numerical and functional defects of invariant natural killer T cells (iNKT) have been documented in human and mouse cancers, resulting in a defect in IFN…”
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Hepatitis C Virus (HCV)-Specific CD8+ Cells Produce Transforming Growth Factor β That Can Suppress HCV-Specific T-Cell Responses by Alatrakchi, Nadia, Graham, Camilla S, van der Vliet, Hans J J, Sherman, Kenneth E, Exley, Mark A, Koziel, Margaret James

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR α‐chain CDR3 loop by Exley, Mark A., Hou, Runhua, Shaulov, Angela, Tonti, Elena, Dellabona, Paolo, Casorati, Giulia, Akbari, Omid, Akman, H. Orhan, Greenfield, Edward A., Gumperz, Jenny E., Boyson, Jonathan E., Balk, Steven P., Wilson, S. Brian

“…A significant fraction of CD1d‐restricted T cells express an invariant T cell receptor (TCR) α‐chain. These highly conserved invariant NKT (iNKT) populations…”
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Loss of effector and anti-inflammatory natural killer T lymphocyte function in pathogenic simian immunodeficiency virus infection by Rout, Namita, Greene, Justin, Yue, Simon, O'Connor, David, Johnson, R Paul, Else, James G, Exley, Mark A, Kaur, Amitinder

“…Chronic immune activation is a key determinant of AIDS progression in HIV-infected humans and simian immunodeficiency virus (SIV)-infected macaques but is…”
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Exploiting CD1-restricted T cells for clinical benefit by Exley, Mark A., Dellabona, Paolo, Casorati, Giulia

“…•CD1-restricted T cells including Invariant Natural Killer cells (iNKT) are innate lymphocytes with potent cytotoxic and cytokine effector…”
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Generation of Antitumor Invariant Natural Killer T Cell Lines in Multiple Myeloma and Promotion of Their Functions via Lenalidomide: A Strategy for Immunotherapy by Song, Weihua, van der Vliet, Hans J J, Tai, Yu-Tzu, Prabhala, Rao, Wang, Ruojie, Podar, Klaus, Catley, Laurence, Shammas, Masood A, Anderson, Kenneth C, Balk, Steven P, Exley, Mark A, Munshi, Nikhil C

“…Purpose: CD1d-restricted invariant natural killer T (iNKT) cells are important immunoregulatory cells in antitumor immune responses. However, the quantitative…”
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Paucity of CD4+ natural killer T (NKT) lymphocytes in sooty mangabeys is associated with lack of NKT cell depletion after SIV infection by Rout, Namita, Else, James G, Yue, Simon, Connole, Michelle, Exley, Mark A, Kaur, Amitinder

“…Lack of chronic immune activation in the presence of persistent viremia is a key feature that distinguishes nonpathogenic simian immunodeficiency virus (SIV)…”
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CD1d Ligation on Human Monocytes Directly Signals Rapid NF-κB Activation and Production of Bioactive IL-12 by Yue, Simon C., Shaulov, Angela, Wang, Ruojie, Balk, Steven P., Exley, Mark A., Cresswell, Peter

“…Natural killer T cells (NKT cells) expressing a semiinvariant CD1d-reactive T cell receptor (invariant NKT, iNKT) can be rapidly activated by monocytes or…”
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Effects of the Administration of High-Dose Interleukin-2 on Immunoregulatory Cell Subsets in Patients with Advanced Melanoma and Renal Cell Cancer by van der Vliet, Hans J, van der Vliet, Hans J J, Koon, Henry B, Yue, Simon C, Uzunparmak, Burak, Seery, Virginia, Gavin, Marc A, Rudensky, Alexander Y, Atkins, Michael B, Balk, Steven P, Exley, Mark A

“…Purpose: High-dose recombinant human interleukin-2 (IL-2) therapy is of clinical benefit in a subset of patients with advanced melanoma and renal cell cancer…”
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