Search Results - "Excoffon, Katherine J.D.A."

Adenovirus transduction: More complicated than receptor expression by Sharma, Priyanka, Martis, Prithy C, Excoffon, Katherine J.D.A

“…Abstract The abundance and accessibility of a primary virus receptor are critical factors that impact the susceptibility of a host cell to virus infection. The…”
Get full text

Adenovirus entry from the apical surface of polarized epithelia is facilitated by the host innate immune response by Kotha, Poornima L N, Sharma, Priyanka, Kolawole, Abimbola O, Yan, Ran, Alghamri, Mahmoud S, Brockman, Trisha L, Gomez-Cambronero, Julian, Excoffon, Katherine J D A

“…Prevention of viral-induced respiratory disease begins with an understanding of the factors that increase or decrease susceptibility to viral infection. The…”
Get full text

Directed evolution of adeno-associated virus to an infectious respiratory virus by Excoffon, Katherine J.D.A, Koerber, James T, Dickey, David D, Murtha, Matthew, Keshavjee, Shaf, Kaspar, Brian K, Zabner, Joseph, Schaffer, David V

“…Respiratory viruses evolve to maintain infectivity levels that permit spread yet prevent host and virus extinction, resulting in surprisingly low infection…”
Get full text

Production of isoform-specific knockdown/knockout Madin–Darby canine kidney epithelial cells using CRISPR/Cas9 by Readler, James M., AlKahlout, Amal S., Kolawole, Abimbola O., Excoffon, Katherine J.D.A.

“…CRISPR-Cas9 gene editing has made it possible to specifically edit genes in a myriad of target cells. Here, a method for isoform-specific editing and clonal…”
Get full text

The coxsackievirus and adenovirus receptor: virological and biological beauty by Excoffon, Katherine J. D. A.

“…The coxsackievirus and adenovirus receptor (CAR) is an essential multifunctional cellular protein that is only beginning to be understood. CAR serves as a…”
Get full text

Poliovirus Receptor: More than a simple viral receptor by Bowers, Jonathan R., Readler, James M., Sharma, Priyanka, Excoffon, Katherine J.D.A.

“…•Human PVR (CD155) is both a viral receptor and immunomodulatory protein.•PVR function depends on expression of alternative protein isoforms.•Poliovirus is a…”
Get full text

The magic of MAGI-1: A scaffolding protein with multi signalosomes and functional plasticity by Excoffon, Katherine J D A, Avila, Christina L, Alghamri, Mahmoud S, Kolawole, Abimbola O

Get full text

SP-101, A Novel Adeno-Associated Virus Gene Therapy for the Treatment of Cystic Fibrosis, Mediates Functional Correction of Primary Human Airway Epithelia From Donors with Cystic Fibrosis by Excoffon, Katherine J D A, Lin, Shen, Narayan, Poornima Kotha Lakshmi, Sitaraman, Sneha, Jimah, Awal M, Fallon, Tyler T, James, Melane L, Glatfelter, Matthew R, Limberis, Maria P, Smith, Mark D, Guffanti, Guia, Kolbeck, Roland

“…Cystic fibrosis (CF) is caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR) protein. Although CF affects multiple…”
Get more information

Isoform specific editing of the coxsackievirus and adenovirus receptor by Readler, James M., AlKahlout, Amal S., Sharma, Priyanka, Excoffon, Katherine J.D.A.

“…The Coxsackievirus and adenovirus receptor (CAR) is both a viral receptor and cell adhesion protein. CAR has two transmembrane isoforms that localize…”
Get full text

Spironolactone Depletes the XPB Protein and Inhibits DNA Damage Responses in UVB-Irradiated Human Skin by Kemp, Michael G., Krishnamurthy, Smita, Kent, Michael N., Schumacher, David L., Sharma, Priyanka, Excoffon, Katherine J.D.A., Travers, Jeffrey B.

“…UVB wavelengths of light induce the formation of photoproducts in genomic DNA that are potentially mutagenic and detrimental to epidermal cell function. The…”
Get full text

The magic of MAGI‐1: A scaffolding protein with multi signalosomes and functional plasticity by Excoffon, Katherine J. D. A., Avila, Christina L., Alghamri, Mahmoud S., Kolawole, Abimbola O.

“…MAGI‐1 is a critical cellular scaffolding protein with over 110 different cellular and microbial protein interactors. Since the discovery of MAGI‐1 in 1997,…”
Get full text

MAGI-1 PDZ2 Domain Blockade Averts Adenovirus Infection via Enhanced Proteolysis of the Apical Coxsackievirus and Adenovirus Receptor by Alghamri, Mahmoud S, Sharma, Priyanka, Williamson, Timothy L, Readler, James M, Yan, Ran, Rider, Jr, S Dean, Hostetler, Heather A, Cool, David R, Kolawole, Abimbola O, Excoffon, Katherine J D A

“…Adenoviruses (AdVs) are etiological agents of gastrointestinal, heart, eye, and respiratory tract infections that can be lethal for immunosuppressed people…”
Get full text

Adenovirus Co-Opts Neutrophilic Inflammation to Enhance Transduction of Epithelial Cells by Readler, James M, Burke, Meghan R, Sharma, Priyanka, Excoffon, Katherine J D A, Kolawole, Abimbola O

“…Human adenoviruses (HAdV) cause a variety of infections in human hosts, from self-limited upper respiratory tract infections in otherwise healthy people to…”
Get full text

A directed evolution approach to select for novel Adeno-associated virus capsids on an HIV-1 producer T cell line by Wooley, Dawn P., Sharma, Priyanka, Weinstein, John R., Kotha Lakshmi Narayan, Poornima, Schaffer, David V., Excoffon, Katherine J.D.A.

“…•A novel AAV directed evolution approach to target parental and HIV-1-infected cells.•Triple infection of H9 T cells with AAV, adenovirus, and HIV-1 was…”
Get full text

CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes by Steines, Benjamin, Dickey, David D, Bergen, Jamie, Excoffon, Katherine Jda, Weinstein, John R, Li, Xiaopeng, Yan, Ziying, Abou Alaiwa, Mahmoud H, Shah, Viral S, Bouzek, Drake C, Powers, Linda S, Gansemer, Nicholas D, Ostedgaard, Lynda S, Engelhardt, John F, Stoltz, David A, Welsh, Michael J, Sinn, Patrick L, Schaffer, David V, Zabner, Joseph

“…The physiological components that contribute to cystic fibrosis (CF) lung disease are steadily being elucidated. Gene therapy could potentially correct these…”
Get full text

319. Improving the Odds of Adenovirus-Mediated Gene Therapy By Upregulation of the Coxsackievirus and Adenovirus Receptor by Excoffon, Katherine J.D.A., Kotha, Poornima L.N., Kolawole, Abimbola O., Yan, Ran, Alghamri, Mahmoud S., Brockman, Brockman L., Gomez-Cambronero, Julian, Sharma, Priyanka

Get full text

The PDZ3 domain of the cellular scaffolding protein MAGI-1 interacts with the Coxsackievirus and adenovirus receptor (CAR) by Yan, Ran, Sharma, Priyanka, Kolawole, Abimbola O., Martin, Sterling C.T., Readler, James M., Kotha, Poornima L.N., Hostetler, Heather A., Excoffon, Katherine J.D.A.

“…The Coxsackievirus and adenovirus receptor (CAR) is an essential cellular protein that is involved in cell–cell adhesion, protein trafficking, and viral…”
Get full text

Isoform-specific regulation and localization of the coxsackie and adenovirus receptor in human airway epithelia by Excoffon, Katherine J D A, Gansemer, Nicholas D, Mobily, Matthew E, Karp, Philip H, Parekh, Kalpaj R, Zabner, Joseph

“…Adenovirus is an important respiratory pathogen. Adenovirus fiber from most serotypes co-opts the Coxsackie-Adenovirus Receptor (CAR) to bind and enter cells…”
Get full text

The Coxsackievirus and Adenovirus Receptor Has a Short Half-Life in Epithelial Cells by Kotha Lakshmi Narayan, Poornima, Readler, James M, Alghamri, Mahmoud S, Brockman, Trisha L, Yan, Ran, Sharma, Priyanka, Snitsarev, Vladislav, Excoffon, Katherine J D A, Kolawole, Abimbola O

“…The coxsackievirus and adenovirus receptor (CAR) is an essential cellular protein that is involved in cell adhesion, cell signaling, and viral infection. The…”
Get full text

A Novel Host Defense System of Airways Is Defective in Cystic Fibrosis by Moskwa, Patryk, Lorentzen, Daniel, Excoffon, Katherine J. D. A, Zabner, Joseph, McCray, Paul B., Jr, Nauseef, William M, Dupuy, Corinne, Banfi, Botond

Get full text