Search Results - "Ewald, Sarah E."

NLRP1 Is an Inflammasome Sensor for Toxoplasma gondii by Ewald, Sarah E, Chavarria-Smith, Joseph, Boothroyd, John C

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Nucleic acid recognition by the innate immune system by Barbalat, Roman, Ewald, Sarah E, Mouchess, Maria L, Barton, Gregory M

“…Receptors of the innate immune system recognize conserved microbial features and provide key signals that initiate immune responses. Multiple transmembrane and…”
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Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase by Ewald, Sarah E, Engel, Alex, Lee, Jiyoun, Wang, Miqi, Bogyo, Matthew, Barton, Gregory M

“…Toll-like receptor (TLR) 9 requires proteolytic processing in the endolysosome to initiate signaling in response to DNA. However, recent studies conflict as to…”
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Transmembrane Mutations in Toll-like Receptor 9 Bypass the Requirement for Ectodomain Proteolysis and Induce Fatal Inflammation by Mouchess, Maria L., Arpaia, Nicholas, Souza, Gianne, Barbalat, Roman, Ewald, Sarah E., Lau, Laura, Barton, Gregory M.

“…Recognition of nucleic acids as a signature of infection by Toll-like receptors (TLRs) 7 and 9 exposes the host to potential self-recognition and autoimmunity…”
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The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor by Lau, Laura, Shi, Guo-Ping, Chapman, Harold A, Lee, Bettina L, Barton, Gregory M, Ewald, Sarah E, Wickliffe, Katherine E

“…Mammalian Toll-like receptors (TLRs) 3, 7, 8 and 9 initiate immune responses to infection by recognizing microbial nucleic acids; however, these responses come…”
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Toxoplasma effector MAF1 mediates recruitment of host mitochondria and impacts the host response by Pernas, Lena, Adomako-Ankomah, Yaw, Shastri, Anjali J, Ewald, Sarah E, Treeck, Moritz, Boyle, Jon P, Boothroyd, John C

“…Recent information has revealed the functional diversity and importance of mitochondria in many cellular processes including orchestrating the innate immune…”
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Toxoplasma gondii infection triggers chronic cachexia and sustained commensal dysbiosis in mice by Hatter, Jessica A, Kouche, Yue Moi, Melchor, Stephanie J, Ng, Katherine, Bouley, Donna M, Boothroyd, John C, Ewald, Sarah E

“…Toxoplasma gondii is a protozoan parasite with a predation-mediated transmission cycle between rodents and felines. Intermediate hosts acquire Toxoplasma by…”
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Disease Tolerance in Toxoplasma Infection by Melchor, Stephanie J, Ewald, Sarah E

“…is a successful protozoan parasite that cycles between definitive felid hosts and a broad range of intermediate hosts, including rodents and humans. Within…”
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iNOS is necessary for GBP-mediated T. gondii clearance in murine macrophages via vacuole nitration and intravacuolar network collapse by Zhao, Xiao-Yu, Lempke, Samantha L., Urbán Arroyo, Jan C., Brown, Isabel G., Yin, Bocheng, Magaj, Magdalena M., Holness, Nadia K., Smiley, Jamison, Redemann, Stefanie, Ewald, Sarah E.

“…Toxoplasma gondii is an obligate intracellular parasite of rodents and humans. Interferon-inducible guanylate binding proteins (GBPs) are mediators of T…”
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Co-transfection of murine NXPE2 and murine glycophorin A confers reactivity with Ter-119 by Keele, Gregory R, Hay, Ariel M, Holness, Nadia K, Jash, Arijita, Ewald, Sarah E, O'Connor, Callan, Vincent, Matthew, Dzieciatkowska, Monika, D'Alessandro, Angelo, Churchill, Gary A, Zimring, James C

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Tricarboxylic acid (TCA) cycle, sphingolipid, and phosphatidylcholine metabolism are dysregulated in T. gondii infection-induced cachexia by Feng, Tzu-Yu, Melchor, Stephanie J., Zhao, Xiao-Yu, Ghumman, Haider, Kester, Mark, Fox, Todd E., Ewald, Sarah E.

“…Cachexia is a life-threatening disease characterized by chronic, inflammatory muscle wasting and systemic metabolic impairment. Despite its high prevalence,…”
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Microbial Pathogenesis in the Era of Spatial Omics by Lempke, Samantha, May, Dana, Ewald, Sarah E

“…The biology of a cell, whether it is a unicellular organism or part of a multicellular network, is influenced by cell type, temporal changes in cell state, and…”
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The molecular biology and immune control of chronic Toxoplasma gondii infection by Zhao, Xiao-Yu, Ewald, Sarah E

“…Toxoplasma gondii is an incredibly successful parasite owing in part to its ability to persist within cells for the life of the host. Remarkably, at least 350…”
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The myeloid receptor PILRβ mediates the balance of inflammatory responses through regulation of IL-27 production by Tato, Cristina M, Joyce-Shaikh, Barbara, Banerjee, Antara, Chen, Yi, Sathe, Manjiri, Ewald, Sarah E, Liu, Man-Ru, Gorman, Daniel, McClanahan, Terrill K, Phillips, Joseph H, Heyworth, Paul G, Cua, Daniel J

“…Paired immunoglobulin-like receptors beta, PILRβ, and alpha, PILRα, are related to the Siglec family of receptors and are expressed primarily on cells of the…”
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How colonization bottlenecks, tissue niches, and transmission strategies shape protozoan infections by May, Dana A, Taha, Fatima, Child, Matthew A, Ewald, Sarah E

“…Protozoan pathogens such as Plasmodium spp., Leishmania spp., Toxoplasma gondii, and Trypanosoma spp. are often associated with high-mortality, acute and…”
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Immunoregulatory Role of NK Cells in Tissue Inflammation and Regeneration by Tosello-Trampont, Annie, Surette, Fionna A, Ewald, Sarah E, Hahn, Young S

“…NK cells represent an important first line of defense against viral infection and cancer and are also involved in tissue homeostasis. Studies of NK cell…”
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Poly I:C vaccination drives transient CXCL9 expression near B cell follicles in the lymph node through type-I and type-II interferon signaling by Ball, Alexander G., Morgaenko, Katerina, Anbaei, Parastoo, Ewald, Sarah E., Pompano, Rebecca R.

“…[Display omitted] •CXCL9 was upregulated after vaccination with Th1 but not Th2 polarizing adjuvants.•Poly I:C induced IFNα + cells, IFNγ + cells, and CXCL9 in…”
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Corrigendum to “Poly I:C vaccination drives transient CXCL9 expression near B cell follicles in the lymph node through type-I and type-II interferon signaling” [Cytokine 183 (2024) 156731] by Ball, Alexander G., Morgaenko, Katerina, Anbaei, Parastoo, Ewald, Sarah E., Pompano, Rebecca R.

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Automated Spatially Targeted Optical Microproteomics (autoSTOMP) to Determine Protein Complexity of Subcellular Structures by Yin, Bocheng, Mendez, Roberto, Zhao, Xiao-Yu, Rakhit, Rishi, Hsu, Ku-Lung, Ewald, Sarah E

“…Spatially targeted optical microproteomics (STOMP) is a method to study region-specific protein complexity in primary cells and tissue samples. STOMP uses a…”
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IL-1R Regulates Disease Tolerance and Cachexia in Toxoplasma gondii Infection by Melchor, Stephanie J, Saunders, Claire M, Sanders, Imani, Hatter, Jessica A, Byrnes, Kari A, Coutermarsh-Ott, Sheryl, Ewald, Sarah E

“…is an obligate intracellular parasite that establishes life-long infection in a wide range of hosts, including humans and rodents. To establish a chronic…”
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