Search Results - "Ewald, Roland"

VPMBench: a test bench for variant prioritization methods by Ruscheinski, Andreas, Reimler, Anna Lena, Ewald, Roland, Uhrmacher, Adelinde M

“…Abstract Background Clinical diagnostics of whole-exome and whole-genome sequencing data requires geneticists to consider thousands of genetic variants for…”
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Spatio-temporal model of endogenous ROS and raft-dependent WNT/beta-catenin signaling driving cell fate commitment in human neural progenitor cells by Haack, Fiete, Lemcke, Heiko, Ewald, Roland, Rharass, Tareck, Uhrmacher, Adelinde M

“…Canonical WNT/β-catenin signaling is a central pathway in embryonic development, but it is also connected to a number of cancers and developmental disorders…”
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Highly sensitive liquid biopsy Duplex sequencing complements tissue biopsy to enhance detection of clinically relevant genetic variants by Hallermayr, Ariane, Neuhann, Teresa M, Steinke-Lange, Verena, Scharf, Florentine, Laner, Andreas, Ewald, Roland, Liesfeld, Ben, Holinski-Feder, Elke, Pickl, Julia M A

“…Liquid biopsy (LB) is a promising complement to tissue biopsy for detection of clinically relevant genetic variants in cancer and mosaic diseases. A combined…”
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Composing problem solvers for simulation experimentation: a case study on steady state estimation by Leye, Stefan, Ewald, Roland, Uhrmacher, Adelinde M

“…Simulation experiments involve various sub-tasks, e.g., parameter optimization, simulation execution, or output data analysis. Many algorithms can be applied…”
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Exploring the performance of spatial stochastic simulation algorithms by Jeschke, Matthias, Ewald, Roland, Uhrmacher, Adelinde M.

“…Since the publication of Gillespie’s direct method, diverse methods have been developed to improve the performance of stochastic simulation methods and to…”
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Spatio-temporal Model of Endogenous ROS and Raft-Dependent WNT/Beta-Catenin Signaling Driving Cell Fate Commitment in Human Neural Progenitor Cells: e1004106 by Haack, Fiete, Lemcke, Heiko, Ewald, Roland, Rharass, Tareck, Uhrmacher, Adelinde M

“…Canonical WNT/β-catenin signaling is a central pathway in embryonic development, but it is also connected to a number of cancers and developmental disorders…”
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A flexible and scalable experimentation layer by Himmelspach, Jan, Ewald, Roland, Uhrmacher, Adelinde M.

“…Modeling and simulation frameworks for use in different application domains, throughout the complete development process, and in different hardware…”
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Flexible experimentation in the modeling and simulation framework JAMES II--implications for computational systems biology by Ewald, Roland, Himmelspach, Jan, Jeschke, Matthias, Leye, Stefan, Uhrmacher, Adelinde M

“…Dry-lab experimentation is being increasingly used to complement wet-lab experimentation. However, conducting dry-lab experiments is a challenging endeavor…”
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From standardized modeling formats to modeling languages and back - An exploration based on SBML and ML-Rules by Nahring, Sebastian, Ewald, Roland, Uhrmacher, Adelinde M., Maus, Carsten

“…Standardized model exchange formats give practitioners the freedom to choose the most suitable tool and facilitate both cross-validation and reproduction of…”
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Flexible experimentation in the modeling and simulation framework JAMES II-implications for computational systems biology: Parallel and Ubiquitous Methods and Tools in Systems Biology by EWALD, Roland, HIMMELSPACH, Jan, JESCHKE, Matthias, LEYE, Stefan, UHRMACHER, Adelinde M

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Data access in distributed simulations of multi-agent systems by Chen, Dan, Ewald, Roland, Theodoropoulos, Georgios K., Minson, Robert, Oguara, Ton, Lees, Michael, Logan, Brian, Uhrmacher, Adelinde M.

“…Distributed simulation has emerged as an important instrument for studying large-scale complex systems. Such systems inherently consist of a large number of…”
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Automating the runtime performance evaluation of simulation algorithms by Ewald, R., Uhrmacher, A.M.

“…Simulation algorithm implementations are usually evaluated by experimental performance analysis. To conduct such studies is a challenging and time-consuming…”
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Combining micro and macro-modeling in DEVS for computational biology by Uhrmacher, A.M., Ewald, R., John, M., Maus, C., Jeschke, M., Biermann, S.

“…In computational biology there is an increasing need to combine micro and macro views of the system of interest. Therefore, explicit means to describe micro…”
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Interactive visual exploration of simulator accuracy: A case study for stochastic simulation algorithms by Luboschik, M., Rybacki, S., Ewald, R., Schwarze, B., Schumann, H., Uhrmacher, A. M.

“…Visual Analytics offers various interesting methods to explore high dimensional data interactively. In this paper we investigate how it can be applied to…”
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Probabilistic population projection with JAMES II by Bohk, C., Ewald, R., Uhrmacher, A.M.

“…Predicting future populations and their structure is a central theme in demography. It is related to public health issues, political decision-making, or urban…”
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A plug-in-based architecture for random number generation in simulation systems by Ewald, Roland, Rossel, Johannes, Himmelspach, Jan, Uhrmacher, Adelinde M.

“…Simulations often depend heavily on random numbers, yet the impact of random number generators is recognized seldom. The generation of random numbers for…”
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A Grid-Inspired Mechanism for Coarse-Grained Experiment Execution by Leye, S., Himmelspach, J., Jeschke, M., Ewald, R., Uhrmacher, A.M.

“…Stochastic simulations may require many replications until their results are statistically significant. Each replication corresponds to a standalone simulation…”
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Experimental analysis of logical process simulation algorithms in JAMES II by Bing Wang, Yiping Yao, Himmelspach, J., Ewald, R., Uhrmacher, A.M.

“…The notion of logical processes is a widely used modeling paradigm in parallel and distributed discrete-event simulation. Yet, the comparison among different…”
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Introducing Variable Ports and Multi-Couplings for Cell Biological Modeling in DEVS by Uhrmacher, A.M., Himmelspach, J., Rohl, M., Ewald, R.

“…Motivated by the requirements of molecular biological applications, we are suggesting an extension of the DEVS formalism. Starting with DYNDEVS a reflective…”
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A Spatial Extension to the π Calculus by John, Mathias, Ewald, Roland, Uhrmacher, Adelinde M.

“…Spatial dynamics receive increasing attention in Systems Biology and require suitable modeling and simulation approaches. So far, modeling formalisms have…”
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