Search Results - "Ewald, Amy"
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Salvinorin A analogs and other κ-opioid receptor compounds as treatments for cocaine abuse
Published in Advances in pharmacology (1990) (2014)“…Acute activation of kappa-opioid receptors produces anti-addictive effects by regulating dopamine levels in the brain. Unfortunately, classic kappa-opioid…”
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The C-2 derivatives of salvinorin A, ethoxymethyl ether Sal B and β-tetrahydropyran Sal B, have anti-cocaine properties with minimal side effects
Published in Psychopharmacology (01-08-2017)“…Rationale Kappa-opioid receptor (KOPr) agonists have pre-clinical anti-cocaine and analgesic effects. However, side effects including sedation, dysphoria,…”
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Synthesis and κ‑Opioid Receptor Activity of Furan-Substituted Salvinorin A Analogues
Published in Journal of medicinal chemistry (26-12-2014)“…The neoclerodane diterpene salvinorin A, found in the leaves of Salvia divinorum, is a potent κ-opioid receptor agonist, making it an attractive scaffold for…”
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The Kappa Opioid Receptor Agonist 16-Bromo Salvinorin A Has Anti-Cocaine Effects without Significant Effects on Locomotion, Food Reward, Learning and Memory, or Anxiety and Depressive-like Behaviors
Published in Molecules (Basel, Switzerland) (01-06-2023)“…Kappa opioid receptor (KOR) agonists have preclinical antipsychostimulant effects; however, adverse side effects have limited their therapeutic development. In…”
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The C-2 derivatives of salvinorin A, ethoxymethyl ether Sal B and [beta]-tetrahydropyran Sal B, have anti-cocaine properties with minimal side effects
Published in Psychopharmacology (01-08-2017)“…Rationale Kappa-opioid receptor (KOPr) agonists have pre-clinical anti-cocaine and analgesic effects. However, side effects including sedation, dysphoria,…”
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Infection and persistence of erythrovirus B19 in benign and cancerous thyroid tissues
Published in Journal of medical virology (01-09-2014)“…Human erythrovirus B19 (EVB19) is a small, pathogenic DNA virus that has been associated with a wide range of illnesses. The primary site of replication is in…”
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Quantifying burden of intravitreal injections: questionnaire assessment of life impact of treatment by intravitreal injections (QUALITII)
Published in BMJ open ophthalmology (01-12-2022)“…AimTo quantify the areas of burden experienced by patients requiring repeated intravitreal injections (IVI) in the management of exudative retinal…”
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Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism
Published in Neuropharmacology (01-11-2014)“…Salvinorin A (SalA), a selective κ-opioid receptor (KOR) agonist, produces dysphoria and pro-depressant like effects. These actions have been attributed to…”
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The kappa opioid receptor agonist 16-bromosalvinorin a reduces cocaine seeking in rats
Published in Drug and alcohol dependence (01-11-2015)Get full text
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Infection and persistence of erythrovirus B19 in benign and cancerous thyroid tissues: Erythrovirus B19 Infection of the Thyroid
Published in Journal of medical virology (01-09-2014)Get full text
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The 2-methoxy methyl analogue of salvinorin A attenuates cocaine-induced drug seeking and sucrose reinforcements in rats
Published in European journal of pharmacology (15-11-2013)“…κ Opioid receptor activation by traditional arylacetamide agonists and the novel neoclerodane diterpene κ opioid receptor agonist Salvinorin A (Sal A) results…”
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