Protective effects of caffeic acid phenethyl ester on dose-dependent intoxication of rats with paraquat

Purpose: Paraquat (PQ; 1,1′dimethyl-bipyridilium 4,4′-dichloride), which is used extensively throughout the world, is highly toxic to humans. We aimed to investigate the protective effects of different doses of caffeic acid phenethyl ester (CAPE) on PQ-intoxicated rats. Materials and methods: A tota...

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Bibliographic Details
Published in:	Toxicology and industrial health Vol. 31; no. 11; pp. 1000 - 1007
Main Authors:	Silfeler, Ibrahim, Alp, Harun, Ozgur, Tumay, Evlioglu, Osman, Celik, Murat, Er, Metin, Yilmaz, Gulsah
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-11-2015 Sage Publications Ltd
Subjects:	Acids Animals Antioxidants - pharmacology Caffeic Acids - pharmacology Dose-Response Relationship, Drug Drug dosages Enzymes Female Intoxication Medical research Medicine Pancreas - drug effects Pancreas - pathology Paraquat Paraquat - toxicity Pediatrics Phenylethyl Alcohol - analogs & derivatives Phenylethyl Alcohol - pharmacology Rats Rats, Wistar Istanbul Turkey Germany Turkey Caffeic acid phenethyl ester pancreas paraquat
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Summary:	Purpose: Paraquat (PQ; 1,1′dimethyl-bipyridilium 4,4′-dichloride), which is used extensively throughout the world, is highly toxic to humans. We aimed to investigate the protective effects of different doses of caffeic acid phenethyl ester (CAPE) on PQ-intoxicated rats. Materials and methods: A total of 80 rats were divided into the following eight groups, comprising 10 rats in each group: group 1: control; group 2: administered with CAPE (10 µmol/kg); group 3: administered with 15 mg/kg PQ (PQ15 group); group 4: administered with 30 mg/kg PQ (PQ30 group); group 5: administered with 45 mg/kg PQ (PQ45 group); group 6: administered with 15 mg/kg PQ + CAPE; group 7: administered with 30 mg/kg PQ + CAPE and group 8: administered with 45 mg/kg PQ + CAPE. Both PQ and CAPE were injected intraperitoneally. Pancreatic tissue was examined with both haematoxylin and eosin and immunochemical staining. Results: The ratio of the immunohistochemical staining area to the total pancreatic area of the β cells revealed that statistically significant differences were observed only between the PQ and PQ + CAPE groups (p < 0.05). Discussion: The evaluation of the data suggests that CAPE can be used to prevent acute effects of PQ intoxication.
ISSN:	0748-2337 1477-0393
DOI:	10.1177/0748233713484658