Search Results - "Eversley, Judith A"
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1
Rapid Elevation in CMPF May Act As a Tipping Point in Diabetes Development
Published in Cell reports (Cambridge) (29-03-2016)“…Prediabetes, a state of mild glucose intolerance, can persist for years before a sudden decline in beta cell function and rapid deterioration to overt…”
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2
CMPF, a Metabolite Formed Upon Prescription Omega-3-Acid Ethyl Ester Supplementation, Prevents and Reverses Steatosis
Published in EBioMedicine (01-01-2018)“…Prescription ω-3 fatty acid ethyl ester supplements are commonly used for the treatment of hypertriglyceridemia. However, the metabolic profile and effect of…”
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3
Elevated Medium-Chain Acylcarnitines Are Associated With Gestational Diabetes Mellitus and Early Progression to Type 2 Diabetes and Induce Pancreatic β-Cell Dysfunction
Published in Diabetes (New York, N.Y.) (01-05-2018)“…Specific circulating metabolites have emerged as important risk factors for the development of diabetes. The acylcarnitines (acylCs) are a family of…”
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4
β-Cell Insulin Resistance Plays a Causal Role in Fat-Induced β-Cell Dysfunction In Vitro and In Vivo
Published in Endocrinology (Philadelphia) (29-03-2024)“…Abstract In the classical insulin target tissues of liver, muscle, and adipose tissue, chronically elevated levels of free fatty acids (FFA) impair insulin…”
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Hypothalamic miR-1983 Targets Insulin Receptor β and the Insulin-mediated miR-1983 Increase Is Blocked by Metformin
Published in Endocrinology (Philadelphia) (01-01-2022)“…MicroRNAs (miRNAs) expressed in the hypothalamus are capable of regulating energy balance and peripheral metabolism by inhibiting translation of target…”
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6
IKKβ inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents
Published in Diabetologia (01-10-2017)“…Aims/hypothesis We have previously shown that oxidative stress plays a causal role in beta cell dysfunction induced by fat. Here, we address whether the…”
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7
Hypothalamic miR-1983 Targets Insulin Receptor [beta] and the Insulin-mediated miR-1983 Increase Is Blocked by Metformin
Published in Endocrinology (Philadelphia) (01-01-2022)“…MicroRNAs (miRNAs) expressed in the hypothalamus are capable of regulating energy balance and peripheral metabolism by inhibiting translation of target…”
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Journal Article -
8
IKK[beta] inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents
Published in Diabetologia (01-10-2017)“…Aims/hypothesis We have previously shown that oxidative stress plays a causal role in beta cell dysfunction induced by fat. Here, we address whether the…”
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