Search Results - "Evans, Trent D."

TFEB and trehalose drive the macrophage autophagy-lysosome system to protect against atherosclerosis by Evans, Trent D., Jeong, Se-Jin, Zhang, Xiangyu, Sergin, Ismail, Razani, Babak

“…In the atherosclerotic plaque, macrophages are the key catabolic workhorse responsible for clearing lipid and dead cell debris. To survive the highly…”
Get full text

ATP biosensor reveals microbial energetic dynamics and facilitates bioproduction by Mu, Xinyue, Evans, Trent D., Zhang, Fuzhong

“…Adenosine-5’-triphosphate (ATP), the primary energy currency in cellular processes, drives metabolic activities and biosynthesis. Despite its importance,…”
Get full text

Classical and alternative roles for autophagy in lipid metabolism by Zhang, Xiangyu, Evans, Trent D, Jeong, Se-Jin, Razani, Babak

“…Intracellular lipid metabolism is a complex interplay of exogenous lipid handling, trafficking, storage, lipolysis, and export. Recent work has implicated the…”
Get full text

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis by Sergin, Ismail, Evans, Trent D., Zhang, Xiangyu, Bhattacharya, Somashubhra, Stokes, Carl J., Song, Eric, Ali, Sahl, Dehestani, Babak, Holloway, Karyn B., Micevych, Paul S., Javaheri, Ali, Crowley, Jan R., Ballabio, Andrea, Schilling, Joel D., Epelman, Slava, Weihl, Conrad C., Diwan, Abhinav, Fan, Daping, Zayed, Mohamed A., Razani, Babak

“…Macrophages specialize in removing lipids and debris present in the atherosclerotic plaque. However, plaque progression renders macrophages unable to degrade…”
Get full text

Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis by Sergin, Ismail, Bhattacharya, Somashubhra, Emanuel, Roy, Esen, Emel, Stokes, Carl J, Evans, Trent D, Arif, Batool, Curci, John A, Razani, Babak

“…Autophagy is a catabolic cellular mechanism that degrades dysfunctional proteins and organelles. Atherosclerotic plaque formation is enhanced in mice with…”
Get more information

TFEB is a master regulator of tumor-associated macrophages in breast cancer by Li, Yong, Hodge, Johnie, Liu, Qing, Wang, Junfeng, Wang, Yuzhen, Evans, Trent D, Altomare, Diego, Yao, Yongzhong, Murphy, E Angela, Razani, Babak, Fan, Daping

“…Tumor-associated macrophages (TAMs) play key roles in the development of many malignant solid tumors including breast cancer. They are educated in the tumor…”
Get full text

Transcriptional factor EB regulates macrophage polarization in the tumor microenvironment by Fang, Liang, Hodge, Johnie, Saaoud, Fatma, Wang, Junfeng, Iwanowycz, Stephen, Wang, Yuzhen, Hui, Yvonne, Evans, Trent D., Razani, Babak, Fan, Daping

“…Tumor microenvironment (TME) contains a variety of infiltrating immune cells. Among them, tumor-associated macrophages (TAMs) and their alternative activation…”
Get full text

A shift in energy metabolism anticipates the onset of sarcopenia in rhesus monkeys by Pugh, Thomas D., Conklin, Matthew W., Evans, Trent D., Polewski, Michael A., Barbian, Hannah J., Pass, Rachelle, Anderson, Bradley D., Colman, Ricki J., Eliceiri, Kevin W., Keely, Patricia J., Weindruch, Richard, Beasley, T. Mark, Anderson, Rozalyn M.

“…Summary Age‐associated skeletal muscle mass loss curtails quality of life and may contribute to defects in metabolic homeostasis in older persons. The onset of…”
Get full text

Cellular adaptation contributes to calorie restriction-induced preservation of skeletal muscle in aged rhesus monkeys by McKiernan, Susan H., Colman, Ricki J., Aiken, Erik, Evans, Trent D., Beasley, T. Mark, Aiken, Judd M., Weindruch, Richard, Anderson, Rozalyn M.

“…We have previously shown that a 30% reduced calorie intake diet delayed the onset of muscle mass loss in adult monkeys between ~16 and ~22years of age and…”
Get full text

Target acquired: Selective autophagy in cardiometabolic disease by Evans, Trent D, Sergin, Ismail, Zhang, Xiangyu, Razani, Babak

“…The accumulation of damaged or excess proteins and organelles is a defining feature of metabolic disease in nearly every tissue. Thus, a central challenge in…”
Get more information

Bacterial metabolic heterogeneity: origins and applications in engineering and infectious disease by Evans, Trent D, Zhang, Fuzhong

“…[Display omitted] •Molecular noise, feedback, and asymmetric partitioning create metabolic heterogeneity.•Biosensors, mass spectrometry, and Raman spectroscopy…”
Get full text

Degradation and beyond: the macrophage lysosome as a nexus for nutrient sensing and processing in atherosclerosis by Sergin, Ismail, Evans, Trent D, Razani, Babak

“…The ability of macrophage lysosomes to degrade both exogenous and internally derived cargo is paramount to handling the overabundance of lipid and cytotoxic…”
Get full text

Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response by Jeong, Se-Jin, Stitham, Jeremiah, Evans, Trent D., Zhang, Xiangyu, Rodriguez-Velez, Astrid, Yeh, Yu-Sheng, Tao, Joan, Takabatake, Koki, Epelman, Slava, Lodhi, Irfan J., Schilling, Joel D., DeBosch, Brian J., Diwan, Abhinav, Razani, Babak

“…The autophagy-lysosome system is an important cellular degradation pathway that recycles dysfunctional organelles and cytotoxic protein aggregates. A decline…”
Get full text

TFEB drives PGC-1α expression in adipocytes to protect against diet-induced metabolic dysfunction by Evans, Trent D, Zhang, Xiangyu, Jeong, Se-Jin, He, Anyuan, Song, Eric, Bhattacharya, Somashubhra, Holloway, Karyn B, Lodhi, Irfan J, Razani, Babak

“…TFEB is a basic helix-loop-helix transcription factor that confers protection against metabolic diseases such as atherosclerosis by targeting a network of…”
Get more information

Loss of Macrophage mTORC2 Drives Atherosclerosis via FoxO1 and IL-1β Signaling by Zhang, Xiangyu, Evans, Trent D., Chen, Sunny, Sergin, Ismail, Stitham, Jeremiah, Jeong, Se-Jin, Rodriguez-Velez, Astrid, Yeh, Yu-Sheng, Park, Arick, Jung, In-Hyuk, Diwan, Abhinav, Schilling, Joel D., Rom, Oren, Yurdagul, Arif, Epelman, Slava, Cho, Jaehyung, Lodhi, Irfan J., Mittendorfer, Bettina, Razani, Babak

“…The mTOR (mechanistic target of rapamycin) pathway is a complex signaling cascade that regulates cellular growth, proliferation, metabolism, and survival…”
Get full text

Functional Characterization of LIPA (Lysosomal Acid Lipase) Variants Associated With Coronary Artery Disease by Evans, Trent D, Zhang, Xiangyu, Clark, Reece E, Alisio, Arturo, Song, Eric, Zhang, Hanrui, Reilly, Muredach P, Stitziel, Nathan O, Razani, Babak

“…OBJECTIVE:LIPA (lysosomal acid lipase) mediates cholesteryl ester hydrolysis, and patients with rare loss-of-function mutations develop hypercholesterolemia…”
Get full text

Modulating Oxysterol Sensing to Control Macrophage Apoptosis and Atherosclerosis by Evans, Trent D, Sergin, Ismail, Zhang, Xiangyu, Razani, Babak

Get full text

High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy by Zhang, Xiangyu, Sergin, Ismail, Evans, Trent D., Jeong, Se-Jin, Rodriguez-Velez, Astrid, Kapoor, Divya, Chen, Sunny, Song, Eric, Holloway, Karyn B., Crowley, Jan R., Epelman, Slava, Weihl, Conrad C., Diwan, Abhinav, Fan, Daping, Mittendorfer, Bettina, Stitziel, Nathan O., Schilling, Joel D., Lodhi, Irfan J., Razani, Babak

“…High-protein diets are commonly utilized for weight loss, yet they have been reported to raise cardiovascular risk. The mechanisms underlying this risk are…”
Get full text

Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults by DeVan, Allison E, Johnson, Lawrence C, Brooks, Forrest A, Evans, Trent D, Justice, Jamie N, Cruickshank-Quinn, Charmion, Reisdorph, Nichole, Bryan, Nathan S, McQueen, Matthew B, Santos-Parker, Jessica R, Chonchol, Michel B, Bassett, Candace J, Sindler, Amy L, Giordano, Tony, Seals, Douglas R

“…Insufficient nitric oxide (NO) bioavailability plays an important role in endothelial dysfunction and arterial stiffening with aging. Supplementation with…”
Get full text

Hypoxia in Plaque Macrophages: A New Danger Signal for Interleukin-1β Activation? by Sergin, Ismail, Evans, Trent D, Bhattacharya, Somashubhra, Razani, Babak

Get full text