Search Results - "Evans, Ronald M."

Nuclear Receptors, RXR, and the Big Bang by Evans, Ronald M., Mangelsdorf, David J.

“…Isolation of genes encoding the receptors for steroids, retinoids, vitamin D, and thyroid hormone and their structural and functional analysis revealed an…”
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Exercise Mimetics: Impact on Health and Performance by Fan, Weiwei, Evans, Ronald M.

“…The global epidemic of obesity and its associated chronic diseases is largely attributed to an imbalance between caloric intake and energy expenditure. While…”
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A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response by Ding, Ning, Yu, Ruth T., Subramaniam, Nanthakumar, Sherman, Mara H., Wilson, Caroline, Rao, Renuka, Leblanc, Mathias, Coulter, Sally, He, Mingxiao, Scott, Christopher, Lau, Sue L., Atkins, Annette R., Barish, Grant D., Gunton, Jenny E., Liddle, Christopher, Downes, Michael, Evans, Ronald M.

“…Liver fibrosis is a reversible wound-healing response involving TGFβ1/SMAD activation of hepatic stellate cells (HSCs). It results from excessive deposition of…”
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Insights into Negative Regulation by the Glucocorticoid Receptor from Genome-wide Profiling of Inflammatory Cistromes by Uhlenhaut, N. Henriette, Barish, Grant D., Yu, Ruth T., Downes, Michael, Karunasiri, Malith, Liddle, Christopher, Schwalie, Petra, Hübner, Norbert, Evans, Ronald M.

“…How the glucocorticoid receptor (GR) activates some genes while potently repressing others remains an open question. There are three current models for…”
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Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity by Shalapour, Shabnam, Lin, Xue-Jia, Bastian, Ingmar N., Brain, John, Burt, Alastair D., Aksenov, Alexander A., Vrbanac, Alison F., Li, Weihua, Perkins, Andres, Matsutani, Takaji, Zhong, Zhenyu, Dhar, Debanjan, Navas-Molina, Jose A., Xu, Jun, Loomba, Rohit, Downes, Michael, Yu, Ruth T., Evans, Ronald M., Dorrestein, Pieter C., Knight, Rob, Benner, Christopher, Anstee, Quentin M., Karin, Michael

“…IgA + B cells expressing programmed death ligand 1 (PD-L1) and interleukin 10 accumulate in the inflamed livers of humans and mice with non-alcoholic fatty…”
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FGF1 — a new weapon to control type 2 diabetes mellitus by Gasser, Emanuel, Moutos, Christopher P., Downes, Michael, Evans, Ronald M.

“…Key Points Peripherally or centrally injected fibroblast growth factor 1 (FGF1) confers potent metabolic benefits in type 2 diabetes mellitus (T2DM) FGF1…”
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NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function by Yamamoto, Hiroyasu, Williams, Evan G., Mouchiroud, Laurent, Cantó, Carles, Fan, Weiwei, Downes, Michael, Héligon, Christophe, Barish, Grant D., Desvergne, Béatrice, Evans, Ronald M., Schoonjans, Kristina, Auwerx, Johan

“…Transcriptional coregulators control the activity of many transcription factors and are thought to have wide-ranging effects on gene expression patterns. We…”
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Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis by Mihaylova, Maria M., Vasquez, Debbie S., Ravnskjaer, Kim, Denechaud, Pierre-Damien, Yu, Ruth T., Alvarez, Jacqueline G., Downes, Michael, Evans, Ronald M., Montminy, Marc, Shaw, Reuben J.

“…Class IIa histone deacetylases (HDACs) are signal-dependent modulators of transcription with established roles in muscle differentiation and neuronal survival…”
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Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis by Seidman, Jason S., Troutman, Ty D., Sakai, Mashito, Gola, Anita, Spann, Nathanael J., Bennett, Hunter, Bruni, Cassi M., Ouyang, Zhengyu, Li, Rick Z., Sun, Xiaoli, Vu, BaoChau T., Pasillas, Martina P., Ego, Kaori M., Gosselin, David, Link, Verena M., Chong, Ling-Wa, Evans, Ronald M., Thompson, Bonne M., McDonald, Jeffrey G., Hosseini, Mojgan, Witztum, Joseph L., Germain, Ronald N., Glass, Christopher K.

“…Tissue-resident and recruited macrophages contribute to both host defense and pathology. Multiple macrophage phenotypes are represented in diseased tissues,…”
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A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease by Caussy, Cyrielle, Tripathi, Anupriya, Humphrey, Greg, Bassirian, Shirin, Singh, Seema, Faulkner, Claire, Bettencourt, Ricki, Rizo, Emily, Richards, Lisa, Xu, Zhenjiang Z., Downes, Michael R., Evans, Ronald M., Brenner, David A., Sirlin, Claude B., Knight, Rob, Loomba, Rohit

“…The presence of cirrhosis in nonalcoholic-fatty-liver-disease (NAFLD) is the most important predictor of liver-related mortality. Limited data exist concerning…”
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BRD4 is a novel therapeutic target for liver fibrosis by Ding, Ning, Hah, Nasun, Yu, Ruth T., Sherman, Mara H., Benner, Chris, Leblanc, Mathias, He, Mingxiao, Liddle, Christopher, Downes, Michael, Evans, Ronald M.

“…Liver fibrosis is characterized by the persistent deposition of extracellular matrix components by hepatic stellate cell (HSC)-derived myofibroblasts. It is…”
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Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice by Hartmann, Phillipp, Hochrath, Katrin, Horvath, Angela, Chen, Peng, Seebauer, Caroline T., Llorente, Cristina, Wang, Lirui, Alnouti, Yazen, Fouts, Derrick E., Stärkel, Peter, Loomba, Rohit, Coulter, Sally, Liddle, Christopher, Yu, Ruth T., Ling, Lei, Rossi, Stephen J., DePaoli, Alex M., Downes, Michael, Evans, Ronald M., Brenner, David A., Schnabl, Bernd

“…Alcoholic liver disease (ALD) is associated with changes in the intestinal microbiota. Functional consequences of alcohol‐associated dysbiosis are largely…”
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A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression by Auciello, Francesca R, Bulusu, Vinay, Oon, Chet, Tait-Mulder, Jacqueline, Berry, Mark, Bhattacharyya, Sohinee, Tumanov, Sergey, Allen-Petersen, Brittany L, Link, Jason, Kendsersky, Nicholas D, Vringer, Esmee, Schug, Michelle, Novo, David, Hwang, Rosa F, Evans, Ronald M, Nixon, Colin, Dorrell, Craig, Morton, Jennifer P, Norman, Jim C, Sears, Rosalie C, Kamphorst, Jurre J, Sherman, Mara H

“…Pancreatic ductal adenocarcinoma (PDAC) develops a pronounced stromal response reflecting an aberrant wound-healing process. This stromal reaction features…”
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commonly used antimicrobial additive triclosan is a liver tumor promoter by Yueh, Mei-Fei, Taniguchi, Koji, Chen, Shujuan, Evans, Ronald M., Hammock, Bruce D., Karin, Michael, Tukey, Robert H.

“…Significance Triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol; TCS] is a broad-spectrum antimicrobial agent that has become one of the most common additives…”
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Depletion of fat-resident Treg cells prevents age-associated insulin resistance by Bapat, Sagar P., Myoung Suh, Jae, Fang, Sungsoon, Liu, Sihao, Zhang, Yang, Cheng, Albert, Zhou, Carmen, Liang, Yuqiong, LeBlanc, Mathias, Liddle, Christopher, Atkins, Annette R., Yu, Ruth T., Downes, Michael, Evans, Ronald M., Zheng, Ye

“…Fat-resident regulatory T cells (fT reg cells) accumulate in adipose tissue of mice as a function of age, but not obesity; mice without fT reg cells are…”
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The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming by Panopoulos, Athanasia D, Yanes, Oscar, Ruiz, Sergio, Kida, Yasuyuki S, Diep, Dinh, Tautenhahn, Ralf, Herrerías, Aída, Batchelder, Erika M, Plongthongkum, Nongluk, Lutz, Margaret, Berggren, W Travis, Zhang, Kun, Evans, Ronald M, Siuzdak, Gary, Belmonte, Juan Carlos Izpisua

“…Metabolism is vital to every aspect of cell function, yet the metabolome of induced pluripotent stem cells （iPSCs） remains largely unexplored. Here we report,…”
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ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells by Yoshihara, Eiji, Wei, Zong, Lin, Chun Shi, Fang, Sungsoon, Ahmadian, Maryam, Kida, Yasuyuki, Tseng, Tiffany, Dai, Yang, Yu, Ruth T., Liddle, Christopher, Atkins, Annette R., Downes, Michael, Evans, Ronald M.

“…Pancreatic β cells undergo postnatal maturation to achieve maximal glucose-responsive insulin secretion, an energy intensive process. We identify…”
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Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis by Sun, Xiaoli, Seidman, Jason S., Zhao, Peng, Troutman, Ty D., Spann, Nathanael J., Que, Xuchu, Zhou, Fangli, Liao, Zhongji, Pasillas, Martina, Yang, Xiaohong, Magida, Jason A., Kisseleva, Tatiana, Brenner, David A., Downes, Michael, Evans, Ronald M., Saltiel, Alan R., Tsimikas, Sotirios, Glass, Christopher K., Witztum, Joseph L.

“…Oxidized phospholipids (OxPLs), which arise due to oxidative stress, are proinflammatory and proatherogenic, but their roles in non-alcoholic steatohepatitis…”
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Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis by Chung, Hyo Kyun, Ryu, Dongryeol, Kim, Koon Soon, Chang, Joon Young, Kim, Yong Kyung, Yi, Hyon-Seung, Kang, Seul Gi, Choi, Min Jeong, Lee, Seong Eun, Jung, Saet-Byel, Ryu, Min Jeong, Kim, Soung Jung, Kweon, Gi Ryang, Kim, Hail, Hwang, Jung Hwan, Lee, Chul-Ho, Lee, Se-Jin, Wall, Christopher E, Downes, Michael, Evans, Ronald M, Auwerx, Johan, Shong, Minho

“…Reduced mitochondrial electron transport chain activity promotes longevity and improves energy homeostasis via cell-autonomous and -non-autonomous factors in…”
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Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells by Lister, Ryan, Pelizzola, Mattia, Kida, Yasuyuki S., Hawkins, R. David, Nery, Joseph R., Hon, Gary, Antosiewicz-Bourget, Jessica, O’Malley, Ronan, Castanon, Rosa, Klugman, Sarit, Downes, Michael, Yu, Ruth, Stewart, Ron, Ren, Bing, Thomson, James A., Evans, Ronald M., Ecker, Joseph R.

“…Induced pluripotent stem cells (iPSCs) offer immense potential for regenerative medicine and studies of disease and development. Somatic cell reprogramming…”
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