Search Results - "Evans, Ron J."

Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor by YEH, Tammie C, MARSH, Vivienne, MARLOW, Allison, HURLEY, Brian, LYSSIKATOS, Joe, LEE, Patrice A, WINKLER, James D, KOCH, Kevin, WALLACE, Eli, BERNAT, Bryan A, BALLARD, Josh, COLWELL, Heidi, EVANS, Ron J, PARRY, Janet, SMITH, Darin, BRANDHUBER, Barbara J, GROSS, Stefan

“…Purpose: The Ras-Raf-mitogen-activated protein kinase kinase (MEK) pathway is overactive in many human cancers and is thus a target for novel therapeutics. We…”
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Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist by Eisenberg, Stephen P, Evans, Ron J, Arend, William P, Verderber, Evie, Brewer, Michael T, Hannum, Charles H, Thompson, Robert C

“…Human monocytes induced with adherent IgG secrete an interleukin-1 receptor antagonist which could be important for the in vivo regulation of IL-1 activity. A…”
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Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections by Critchley, Ian A., Green, Louis S., Young, Casey L., Bullard, James M., Evans, Ron J., Price, Melissa, Jarvis, Thale C., Guiles, Joseph W., Janjic, Nebojsa, Ochsner, Urs A.

“…Objectives The aim of this study was to characterize the antimicrobial profile of REP3123, a novel inhibitor of methionyl-tRNA synthetase (MetRS) in…”
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Mapping receptor binding sites in interleukin (IL)-1 receptor antagonist and IL-1 beta by site-directed mutagenesis. Identification of a single site in IL-1ra and two sites in IL-1 beta by Evans, R J, Bray, J, Childs, J D, Vigers, G P, Brandhuber, B J, Skalicky, J J, Thompson, R C, Eisenberg, S P

“…Interleukin-1 receptor antagonist (IL-1ra), an IL-1 family member, binds with high affinity to the type I IL-1 receptor (IL-1RI), blocking IL-1 binding but not…”
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X-ray structure of interleukin-1 receptor antagonist at 2.0-A resolution by VIGERS, G. P. A, CAFFES, P, EVANS, R. J, THOMPSON, R. C, EISENBERG, S. P, BRANDHUBER, B. J

“…Interleukin-1 receptor antagonist (IL-1ra) is a natural competitive antagonist of IL-1. In order to further elucidate the mechanism by which IL-1ra binds…”
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Mapping Receptor Binding Sites in Interleukin (IL)-1 Receptor Antagonist and IL-1β by Site-directed Mutagenesis by Evans, Ron J., Bray, Jeff, Childs, John D., Vigers, Guy P.A., Brandhuber, Barbara J., Skalicky, Jack J., Thompson, Robert C., Eisenberg, Stephen P.

“…Interleukin-1 receptor antagonist (IL-1ra), an IL-1 family member, binds with high affinity to the type I IL-1 receptor (IL-1RI), blocking IL-1 binding but not…”
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