Search Results - "Evans, RM"

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach by Krug, Anne K., Kolde, Raivo, Gaspar, John A., Rempel, Eugen, Balmer, Nina V., Meganathan, Kesavan, Vojnits, Kinga, Baquié, Mathurin, Waldmann, Tanja, Ensenat-Waser, Roberto, Jagtap, Smita, Evans, Richard M., Julien, Stephanie, Peterson, Hedi, Zagoura, Dimitra, Kadereit, Suzanne, Gerhard, Daniel, Sotiriadou, Isaia, Heke, Michael, Natarajan, Karthick, Henry, Margit, Winkler, Johannes, Marchan, Rosemarie, Stoppini, Luc, Bosgra, Sieto, Westerhout, Joost, Verwei, Miriam, Vilo, Jaak, Kortenkamp, Andreas, Hescheler, Jürgen, Hothorn, Ludwig, Bremer, Susanne, van Thriel, Christoph, Krause, Karl-Heinz, Hengstler, Jan G., Rahnenführer, Jörg, Leist, Marcel, Sachinidis, Agapios

“…Developmental neurotoxicity (DNT) and many forms of reproductive toxicity (RT) often manifest themselves in functional deficits that are not necessarily based…”
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Genetic Profiling Defines the Xenobiotic Gene Network Controlled by the Nuclear Receptor Pregnane X Receptor by Rosenfeld, John M, Vargas, Reynaldo, Xie, Wen, Evans, Ronald M

“…The orphan nuclear receptor pregnane X receptor (PXR) is essential for the transcriptional regulation of hepatic xenobiotic enzymes including the cytochrome 3A…”
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ORL1 receptor-mediated internalization of N-type calcium channels by Zamponi, Gerald W, Altier, Christophe, Khosravani, Houman, Evans, Rhian M, Hameed, Shahid, Peloquin, Jean B, Vartian, Brian A, Chen, Lina, Beedle, Aaron M, Ferguson, Stephen S G, Mezghrani, Alexandre, Dubel, Stefan J, Bourinet, Emmanuel, McRory, John E

“…The inhibition of N-type calcium channels by opioid receptor like receptor 1 (ORL1) is a key mechanism for controlling the transmission of nociceptive signals…”
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β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity by Valentine, Joseph M, Ahmadian, Maryam, Keinan, Omer, Abu-Odeh, Mohammad, Zhao, Peng, Zhou, Xin, Keller, Mark P, Gao, Hui, Yu, Ruth T, Liddle, Christopher, Downes, Michael, Zhang, Jin, Lusis, Aldons J, Attie, Alan D, Evans, Ronald M, Rydén, Mikael, Saltiel, Alan R

“…The dysregulation of energy homeostasis in obesity involves multihormone resistance. Although leptin and insulin resistance have been well characterized,…”
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PPAR delta: a dagger in the heart of the metabolic syndrome by Barish, Grant D, Narkar, Vihang A, Evans, Ronald M

“…Obesity is a growing threat to global health by virtue of its association with insulin resistance, glucose intolerance, hypertension, and dyslipidemia,…”
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Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes by Keinan, Omer, Valentine, Joseph M., Xiao, Haopeng, Mahata, Sushil K., Reilly, Shannon M., Abu-Odeh, Mohammad, Deluca, Julia H., Dadpey, Benyamin, Cho, Leslie, Pan, Austin, Yu, Ruth T., Dai, Yang, Liddle, Christopher, Downes, Michael, Evans, Ronald M., Lusis, Aldons J., Laakso, Markku, Chouchani, Edward T., Rydén, Mikael, Saltiel, Alan R.

“…Adipocytes increase energy expenditure in response to prolonged sympathetic activation via persistent expression of uncoupling protein 1 (UCP1) 1 , 2 . Here we…”
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PPARs and the complex journey to obesity by Evans, Ronald M, Barish, Grant D, Wang, Yong-Xu

“…Obesity and the related disorders of dyslipidemia and diabetes (components of syndrome X) have become global health epidemics. Over the past decade, the…”
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The Nuclear Receptor Superfamily: A Rosetta Stone for Physiology by Evans, Ronald M

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Minireview: Lipid Metabolism, Metabolic Diseases, and Peroxisome Proliferator-Activated Receptors by Lee, Chih-Hao, Olson, Peter, Evans, Ronald M

“…Lipid and carbohydrate homeostasis in higher organisms is under the control of an integrated system that has the capacity to rapidly respond to metabolic…”
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Economic Value of Eptfe Stent-Grafts Compared to Balloon Angioplasty for Treating Thrombosed and Dysfunctional Arteriovenous Grafts in England by Mohr, BA, Evans, RM

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PMD30 - Economic Value of Eptfe Stent-Grafts Compared to Balloon Angioplasty for Treating Thrombosed and Dysfunctional Arteriovenous Grafts in England by Mohr, BA, Evans, RM

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Regulation of Muscle Fiber Type and Running Endurance by PPARδ by Wang, Yong-Xu, Zhang, Chun-Li, Yu, Ruth T, Cho, Helen K, Nelson, Michael C, Bayuga-Ocampo, Corinne R, Ham, Jungyeob, Kang, Heonjoong, Evans, Ronald M

“…Endurance exercise training can promote an adaptive muscle fiber transformation and an increase of mitochondrial biogenesis by triggering scripted changes in…”
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Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity by Wang, Yong-Xu, Lee, Chih-Hao, Tiep, Sambath, Yu, Ruth T, Ham, Jungyeob, Kang, Heonjoong, Evans, Ronald M

“…In contrast to the well-established roles of PPARγ and PPARα in lipid metabolism, little is known for PPARδ in this process. We show here that targeted…”
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PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3 by Montminy, Marc, Koo, Seung-Hoi, Satoh, Hiroaki, Herzig, Stephan, Lee, Chih-Hao, Hedrick, Susan, Kulkarni, Rohit, Evans, Ronald M, Olefsky, Jerrold

“…Insulin resistance is a major hallmark in the development of type 2 diabetes, which is characterized by an impaired ability of insulin to inhibit glucose…”
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PPARδ Regulates Glucose Metabolism and Insulin Sensitivity by Lee, Chih-Hao, Olson, Peter, Hevener, Andrea, Mehl, Isaac, Chong, Ling-Wa, Olefsky, Jerrold M., Gonzalez, Frank J., Ham, Jungyeob, Kang, Heonjoong, Peters, Jeffrey M., Evans, Ronald M.

“…The metabolic syndrome is a collection of obesity-related disorders. The peroxisome proliferator-activated receptors (PPARs) regulate transcription in response…”
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PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation by Evans, Ronald M, Chawla, Ajay, Barak, Yaacov, Nagy, Laszlo, Liao, Debbie, Tontonoz, Peter

“…Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is highly expressed in lipid-accumulating macrophages of the coronary artery. In light of this,…”
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Transcriptional Repression of Atherogenic Inflammation: Modulation by PPARδ by Lee, Chih-Hao, Chawla, Ajay, Urbiztondo, Ned, Liao, Debbie, Boisvert, William A., Evans, Ronald M., Curtiss, Linda K.

“…The formation of an atherosclerotic lesion is mediated by lipid-laden macrophages (foam cells), which also establish chronic inflammation associated with…”
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Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle by He, W, Barak, Y, Hevener, A, Olson, P, Liao, D, Le, J, Nelson, M, Ong, E, Olefsky, J.M, Evans, R.M

“…Syndrome X, typified by obesity, insulin resistance (IR), dyslipidemia, and other metabolic abnormalities, is responsive to antidiabetic thiazolidinediones…”
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Nuclear Receptors and Lipid Physiology: Opening the X-Files by Chawla, Ajay, Repa, Joyce J., Evans, Ronald M., Mangelsdorf, David J.

“…Cholesterol, fatty acids, fat-soluble vitamins, and other lipids present in our diets are not only nutritionally important but serve as precursors for ligands…”
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Muscle-specific Pparg deletion causes insulin resistance by Evans, Ronald M, Olefsky, Jerrold, Hevener, Andrea L, He, Weimin, Barak, Yaacov, Le, Jamie, Bandyopadhyay, Gautam, Olson, Peter, Wilkes, Jason

“…Thiazolidinediones (TZDs) are insulin-sensitizing drugs and are potent agonists of the nuclear peroxisome proliferator-activated receptor-gamma (PPAR-gamma)…”
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