Search Results - "Evans, Karleyton C"

Trial of Cinpanemab in Early Parkinson’s Disease by Lang, Anthony E., Siderowf, Andrew D., Macklin, Eric A., Poewe, Werner, Brooks, David J., Fernandez, Hubert H., Rascol, Olivier, Giladi, Nir, Stocchi, Fabrizio, Tanner, Caroline M., Postuma, Ronald B., Simon, David K., Tolosa, Eduardo, Mollenhauer, Brit, Cedarbaum, Jesse M., Fraser, Kyle, Xiao, James, Evans, Karleyton C., Graham, Danielle L., Sapir, Inbal, Inra, Jennifer, Hutchison, R. Matthew, Yang, Minhua, Fox, Tara, Budd Haeberlein, Samantha, Dam, Tien

“…In a phase 2 trial in early Parkinson’s disease, treatment with cinpanemab, a monoclonal antibody to α-synuclein, did not affect clinical or imaging…”
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Intrinsic Functional Connectivity As a Tool For Human Connectomics: Theory, Properties, and Optimization by Van Dijk, Koene R. A, Hedden, Trey, Venkataraman, Archana, Evans, Karleyton C, Lazar, Sara W, Buckner, Randy L

“…1 Department of Psychology, Center for Brain Science, Harvard University, Cambridge, Massachusetts; 2 Athinoula A. Martinos Center for Biomedical Imaging,…”
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A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression by Dougherty, Darin D, Rezai, Ali R, Carpenter, Linda L, Howland, Robert H, Bhati, Mahendra T, O’Reardon, John P, Eskandar, Emad N, Baltuch, Gordon H, Machado, Andre D, Kondziolka, Douglas, Cusin, Cristina, Evans, Karleyton C, Price, Lawrence H, Jacobs, Karen, Pandya, Mayur, Denko, Timothey, Tyrka, Audrey R, Brelje, Tim, Deckersbach, Thilo, Kubu, Cynthia, Malone, Donald A

“…Abstract Background Multiple open-label trials of deep brain stimulation (DBS) for treatment-resistant depression (TRD), including those targeting the ventral…”
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Cortico-limbic circuitry and the airways: Insights from functional neuroimaging of respiratory afferents and efferents by Evans, Karleyton C.

“…After nearly two decades of active research, functional neuroimaging has demonstrated utility in the identification of cortical, limbic, and paralimbic…”
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Cerebrovascular reactivity assessment with O2-CO2 exchange ratio under brief breath hold challenge by Chan, Suk-Tak, Evans, Karleyton C, Song, Tian-Yue, Selb, Juliette, van der Kouwe, Andre, Rosen, Bruce R, Zheng, Yong-Ping, Ahn, Andrew, Kwong, Kenneth K

“…Hypercapnia during breath holding is believed to be the dominant driver behind the modulation of cerebral blood flow (CBF). However, increasing evidence show…”
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FDG PET Parkinson’s disease-related pattern as a biomarker for clinical trials in early stage disease by Matthews, Dawn C., Lerman, Hedva, Lukic, Ana, Andrews, Randolph D., Mirelman, Anat, Wernick, Miles N., Giladi, Nir, Strother, Stephen C., Evans, Karleyton C., Cedarbaum, Jesse M., Even-Sapir, Einat

“…The development of therapeutic interventions for Parkinson disease (PD) is challenged by disease complexity and subjectivity of symptom evaluation. A…”
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Regional quantification of cerebral venous oxygenation from MRI susceptibility during hypercapnia by Fan, Audrey P., Evans, Karleyton C., Stout, Jeffrey N., Rosen, Bruce R., Adalsteinsson, Elfar

“…There is an unmet medical need for noninvasive imaging of regional brain oxygenation to manage stroke, tumor, and neurodegenerative diseases. Oxygenation…”
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Dynamic brain-body coupling of breath-by-breath O2-CO2 exchange ratio with resting state cerebral hemodynamic fluctuations by Chan, Suk-Tak, Evans, Karleyton C, Song, Tian-Yue, Selb, Juliette, van der Kouwe, Andre, Rosen, Bruce R, Zheng, Yong-Ping, Ahn, Andrew C, Kwong, Kenneth K

“…The origin of low frequency cerebral hemodynamic fluctuations (CHF) in the resting state remains unknown. Breath-by breath O2-CO2 exchange ratio (bER) has been…”
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Sensitivity of near-infrared spectroscopy and diffuse correlation spectroscopy to brain hemodynamics: simulations and experimental findings during hypercapnia by Selb, Juliette, Boas, David A, Chan, Suk-Tak, Evans, Karleyton C, Buckley, Erin M, Carp, Stefan A

“…Near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS) are two diffuse optical technologies for brain imaging that are sensitive to…”
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Evaluating dopamine transporter imaging as an enrichment biomarker in a phase 2 Parkinson’s disease trial by Hutchison, R. Matthew, Evans, Karleyton C, Fox, Tara, Yang, Minhua, Barakos, Jerome, Bedell, Barry J, Cedarbaum, Jesse M, Brys, Miroslaw, Siderowf, Andrew, Lang, Anthony E

“…Abstract Background Dopamine transporter single-photon emission computed tomography (DaT-SPECT) can quantify the functional integrity of the dopaminergic nerve…”
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A functional MRI study of amygdala responses to angry schematic faces in social anxiety disorder by Evans, Karleyton C., Wright, Christopher I., Wedig, Michelle M., Gold, Andrea L., Pollack, Mark H., Rauch, Scott L.

“…Neuroimaging studies using angry or contemptuous human facial photographic stimuli have suggested amygdala hyper‐responsivity in social anxiety disorder (SAD)…”
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The time-course of cortico-limbic neural responses to air hunger by Binks, Andrew P, Evans, Karleyton C, Reed, Jeffrey D, Moosavi, Shakeeb H, Banzett, Robert B

“…Highlights • This is the first report of the time-course of dyspnea related neural activity. • Sub-regions of neural circuitry relate to early and late dyspnea…”
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Neuromelanin and T2-MRI for the assessment of genetically at-risk, prodromal, and symptomatic Parkinson’s disease by Ben Bashat, Dafna, Thaler, Avner, Lerman Shacham, Hedva, Even-Sapir, Einat, Hutchison, Matthew, Evans, Karleyton C., Orr-Urterger, Avi, Cedarbaum, Jesse M., Droby, Amgad, Giladi, Nir, Mirelman, Anat, Artzi, Moran

“…MRI was suggested as a promising method for the diagnosis and assessment of Parkinson’s Disease (PD). We aimed to assess the sensitivity of neuromelanin-MRI…”
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BOLD fMRI Identifies Limbic, Paralimbic, and Cerebellar Activation During Air Hunger by Evans, Karleyton C, Banzett, Robert B, Adams, Lewis, McKay, Leanne, Frackowiak, Richard S. J, Corfield, Douglas R

“…  1 Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115;   2 Department of Respiratory Medicine, National Heart and Lung…”
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Differential prefrontal gray matter correlates of treatment response to fluoxetine or cognitive-behavioral therapy in obsessive–compulsive disorder by Hoexter, Marcelo Q, Dougherty, Darin D, Shavitt, Roseli G, D'Alcante, Carina C, Duran, Fabio L.S, Lopes, Antonio C, Diniz, Juliana B, Batistuzzo, Marcelo C, Evans, Karleyton C, Bressan, Rodrigo A, Busatto, Geraldo F, Miguel, Euripedes C

“…Abstract Nearly one-third of patients with obsessive–compulsive disorder (OCD) fail to respond to adequate therapeutic approaches such as serotonin reuptake…”
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Modulation of spontaneous breathing via limbic/paralimbic–bulbar circuitry: An event-related fMRI study by Evans, Karleyton C., Dougherty, Darin D., Schmid, Annette M., Scannell, Elizabeth, McCallister, Adrienne, Benson, Herbert, Dusek, Jeffery A., Lazar, Sara W.

“…It is well established that pacemaker neurons in the brainstem provide automatic control of breathing for metabolic homeostasis and survival. During waking…”
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A PET Study of Tiagabine Treatment Implicates Ventral Medial Prefrontal Cortex in Generalized Social Anxiety Disorder by EVANS, Karleyton C, SIMON, Naomi M, RAUCH, Scott L, DOUGHERTY, Darin D, HOGE, Elizabeth A, WORTHINGTON, John J, CHOW, Candice, KAUFMAN, Rebecca E, GOLD, Andrea L, FISCHMAN, Alan J, POLLACK, Mark H

“…Corticolimbic circuitry has been implicated in generalized social anxiety disorder (gSAD) by several neuroimaging symptom provocation studies. However, there…”
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Neural predictors of successful brief psychodynamic psychotherapy for persistent depression by Roffman, Joshua L, Witte, Janet M, Tanner, Alexandra S, Ghaznavi, Sharmin, Abernethy, Robert S, Crain, Laura D, Giulino, Patricia U, Lable, Ira, Levy, Raymond A, Dougherty, Darin D, Evans, Karleyton C, Fava, Maurizio

“…Psychodynamic psychotherapy has been used to treat depression for more than a century. However, not all patients respond equally well, and there are few…”
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Quantifying the microvascular origin of BOLD-fMRI from first principles with two-photon microscopy and an oxygen-sensitive nanoprobe by Gagnon, Louis, Sakadžić, Sava, Lesage, Frédéric, Musacchia, Joseph J, Lefebvre, Joël, Fang, Qianqian, Yücel, Meryem A, Evans, Karleyton C, Mandeville, Emiri T, Cohen-Adad, Jülien, Polimeni, Jonathan R, Yaseen, Mohammad A, Lo, Eng H, Greve, Douglas N, Buxton, Richard B, Dale, Anders M, Devor, Anna, Boas, David A

“…The blood oxygenation level-dependent (BOLD) contrast is widely used in functional magnetic resonance imaging (fMRI) studies aimed at investigating neuronal…”
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A randomized study of natalizumab dosing regimens for relapsing–remitting multiple sclerosis by Trojano, Maria, Ramió-Torrentà, Lluís, Grimaldi, Luigi ME, Lubetzki, Catherine, Schippling, Sven, Evans, Karleyton C, Ren, Zheng, Muralidharan, Kumar Kandadi, Licata, Stephanie, Gafson, Arie R

“…Background: REFINE was an exploratory, dose- and frequency-blinded, prospective, randomized, dose-ranging study in relapsing–remitting multiple sclerosis…”
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