Search Results - "Evans, Gareth J O"

Bulk Synaptic Vesicle Endocytosis Is Rapidly Triggered during Strong Stimulation by Clayton, Emma L, Evans, Gareth J. O, Cousin, Michael A

“…Bulk endocytosis in central nerve terminals is activated by strong stimulation; however, the speed at which it is initiated and for how long it persists is…”
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Activity-Dependent Control of Slow Synaptic Vesicle Endocytosis by Cyclin-Dependent Kinase 5 by Evans, Gareth J. O, Cousin, Michael A

“…The stimulated dephosphorylation of the dephosphin group of endocytic proteins by calcineurin and their subsequent rephosphorylation by cyclin-dependent kinase…”
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parkin-induced defects in neurophysiology and locomotion are generated by metabolic dysfunction and not oxidative stress by VINCENT, Amanda, BRIGGS, Laura, CHATWIN, Griff F. J, EMERY, Elizabeth, TOMLINS, Rose, OSWALD, Matt, MIDDLETON, C. Adam, EVANS, Gareth J. O, SWEENEY, Sean T, ELLIOTT, Christopher J. H

“…Parkinson's disease (PD) is characterized by movement disorders, including bradykinesia. Analysis of inherited, juvenile PD, identified several genes linked…”
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Activity-dependent control of bulk endocytosis by protein dephosphorylation in central nerve terminals by Clayton, Emma L., Evans, Gareth J. O., Cousin, Michael A.

“…Bulk endocytosis is the process by which nerve terminals retrieve large amounts of synaptic vesicle membrane during periods of strong stimulation intensity…”
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Physiological regulation of Munc18/nSec1 phosphorylation on serine‐313 by Craig, Tim J., Evans, Gareth J. O., Morgan, Alan

“…Increased protein phosphorylation enhances exocytosis in most secretory cell types, including neurones. However, the molecular mechanisms by which this occurs…”
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Sodium regulates PLC and IP3R‐mediated calcium signaling in invasive breast cancer cells by James, Andrew D., Unthank, Katherine P., Jones, Isobel, Sajjaboontawee, Nattanan, Sizer, Rebecca E., Chawla, Sangeeta, Evans, Gareth J. O., Brackenbury, William J.

“…Intracellular Ca2+ signaling and Na+ homeostasis are inextricably linked via ion channels and co‐transporters, with alterations in the concentration of one ion…”
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Activation of silent and weak synapses by cAMP‐dependent protein kinase in cultured cerebellar granule neurons by Cousin, Michael A., Evans, Gareth J. O.

“…Non‐technical summary  It is accepted that learning involves creating or increasing the activity of existing chemical connections (synapses) between neurons…”
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N1-Src Kinase Is Required for Primary Neurogenesis in Xenopus tropicalis by Lewis, Philip A, Bradley, Isobel C, Pizzey, Alastair R, Isaacs, Harry V, Evans, Gareth J O

“…The presence of the neuronal-specific N1-Src splice variant of the C-Src tyrosine kinase is conserved through vertebrate evolution, suggesting an important…”
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Dopaminergic expression of the Parkinsonian gene LRRK2-G2019S leads to non-autonomous visual neurodegeneration, accelerated by increased neural demands for energy by Hindle, Samantha, Afsari, Farinaz, Stark, Meg, Middleton, C Adam, Evans, Gareth J O, Sweeney, Sean T, Elliott, Christopher J H

“…Parkinson's disease (PD) is associated with loss of dopaminergic signalling, and affects not just movement, but also vision. As both mammalian and fly visual…”
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The schistosome oesophageal gland: initiator of blood processing by Li, Xiao-Hong, de Castro-Borges, William, Parker-Manuel, Sophie, Vance, Gillian M, Demarco, Ricardo, Neves, Leandro X, Evans, Gareth J O, Wilson, R Alan

“…Although the ultrastructure of the schistosome esophageal gland was described >35 years ago, its role in the processing of ingested blood has never been…”
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Multisite tyrosine phosphorylation of the N‐terminus of Mint1/X11α by Src kinase regulates the trafficking of amyloid precursor protein by Dunning, Christopher J. R., Black, Hannah L., Andrews, Katie L., Davenport, Elizabeth C., Conboy, Michael, Chawla, Sangeeta, Dowle, Adam A., Ashford, David, Thomas, Jerry R., Evans, Gareth J. O.

“…Mint/X11 is one of the four neuronal trafficking adaptors that interact with amyloid precursor protein (APP) and are linked with its cleavage to generate…”
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Phosphorylation of cysteine string protein in the brain: developmental, regional and synaptic specificity by Evans, Gareth J. O., Morgan, Alan

“…Protein phosphorylation modulates regulated exocytosis in most cells, including neurons. Cysteine string protein (CSP) has been implicated in this process…”
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Protein Kinase B/Akt Is a Novel Cysteine String Protein Kinase That Regulates Exocytosis Release Kinetics and Quantal Size by Evans, Gareth J.O., Barclay, Jeff W., Prescott, Gerald R., Jo, Sung-Ro, Burgoyne, Robert D., Birnbaum, Morris J., Morgan, Alan

“…Protein kinase B/Akt has been implicated in the insulin-dependent exocytosis of GLUT4-containing vesicles, and, more recently, insulin secretion. To determine…”
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The N2-Src neuronal splice variant of C-Src has altered SH3 domain ligand specificity and a higher constitutive activity than N1-Src by Keenan, Sarah, Lewis, Philip A., Wetherill, Sarah J., Dunning, Christopher J.R., Evans, Gareth J.O.

“…•N2-Src is a previously uncharacterised neuronal splice variant of C-Src kinase.•Tyrosine phosphorylation by C-Src is enhanced by SH3 peptide ligands.•Ideal…”
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Amyloid-β oligomerization monitored by single-molecule stepwise photobleaching by Dresser, Lara, Hunter, Patrick, Yendybayeva, Fatima, Hargreaves, Alex L., Howard, Jamieson A.L., Evans, Gareth J.O., Leake, Mark C., Quinn, Steven D.

“…•Method enables investigation of amyloid-β oligomer stoichiometry without requiring extrinsic fluorescent probes.•Uses single-molecule stepwise photobleaching…”
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The phosphatase Glc7 controls the eisosomal response to starvation via post-translational modification of Pil1 by Paine, Katherine M, Laidlaw, Kamilla M E, Evans, Gareth J O, MacDonald, Chris

“…The yeast (Saccharomyces cerevisiae) plasma membrane (PM) is organised into specific subdomains that regulate surface membrane proteins. Surface transporters…”
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Chirped guided-mode resonance biosensor by Triggs, Graham J, Wang, Yue, Reardon, Christopher P, Fischer, Matthias, Evans, Gareth J O, Krauss, Thomas F

“…Advanced biomedical diagnostic technologies fulfill an important role in improving health and well-being in society. A large number of excellent technologies…”
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Tying Everything Together: The Multiple Roles of Cysteine String Protein (CSP) in Regulated Exocytosis by Evans, Gareth J. O., Morgan, Alan, Burgoyne, Robert D.

“…In addition to the core vesicle fusion machinery, the SNARE proteins, a large number of regulatory proteins have been implicated in the process of…”
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Developmental change in the calcium sensor for synaptic vesicle endocytosis in central nerve terminals by Smillie, Karen J., Evans, Gareth J. O., Cousin, Michael A.

“…Synaptic vesicle endocytosis is stimulated by calcium influx in mature central nerve terminals via activation of the calcium‐dependent protein phosphatase,…”
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S6K2-mediated regulation of TRBP as a determinant of miRNA expression in human primary lymphatic endothelial cells by Warner, Matthew J, Bridge, Katherine S, Hewitson, James P, Hodgkinson, Michael R, Heyam, Alex, Massa, Bailey C, Haslam, Jessica C, Chatzifrangkeskou, Maria, Evans, Gareth J O, Plevin, Michael J, Sharp, Tyson V, Lagos, Dimitris

“…MicroRNAs (miRNAs) are short non-coding RNAs that silence mRNAs. They are generated following transcription and cleavage by the DROSHA/DGCR8 and…”
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