Search Results - "Evans, E. W."

Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing: 2013 Update by Relling, M V, Gardner, E E, Sandborn, W J, Schmiegelow, K, Pui, C-H, Yee, S W, Stein, C M, Carrillo, M, Evans, W E, Hicks, J K, Schwab, M, Klein, T E

“…The Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Methyltransferase Genotype and Thiopurine Dosing was originally…”
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Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing by Relling, MV, Gardner, EE, Sandborn, WJ, Schmiegelow, K, Pui, C‐H, Yee, SW, Stein, CM, Carrillo, M, Evans, WE, Klein, TE

“…Thiopurine methyltransferase (TPMT) activity exhibits monogenic co‐dominant inheritance, with ethnic differences in the frequency of occurrence of variant…”
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Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia by Pui, C H, Pei, D, Sandlund, J T, Ribeiro, R C, Rubnitz, J E, Raimondi, S C, Onciu, M, Campana, D, Kun, L E, Jeha, S, Cheng, C, Howard, S C, Metzger, M L, Bhojwani, D, Downing, J R, Evans, W E, Relling, M V

“…We analyzed the long-term outcome of 1011 patients treated in five successive clinical trials (Total Therapy Studies 11, 12, 13A, 13B, and 14) between 1984 and…”
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Genetic Polymorphism of Inosine Triphosphate Pyrophosphatase Is a Determinant of Mercaptopurine Metabolism and Toxicity During Treatment for Acute Lymphoblastic Leukemia by Stocco, G, Cheok, MH, Crews, KR, Dervieux, T, French, D, Pei, D, Yang, W, Cheng, C, Pui, C‐H, Relling, MV, Evans, WE

“…The influence of genetic polymorphism in inosine triphosphate pyrophosphatase (ITPA) on thiopurine‐induced adverse events has not been investigated in the…”
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Clinical utility and implications of asparaginase antibodies in acute lymphoblastic leukemia by Liu, C, Kawedia, J D, Cheng, C, Pei, D, Fernandez, C A, Cai, X, Crews, K R, Kaste, S C, Panetta, J C, Bowman, W P, Jeha, S, Sandlund, J T, Evans, W E, Pui, C-H, Relling, M V

“…Hypersensitivity to asparaginase is common, but the differential diagnosis can be challenging and the diagnostic utility of antibody tests is unclear. We…”
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Genomewide Approach Validates Thiopurine Methyltransferase Activity Is a Monogenic Pharmacogenomic Trait by Liu, C, Yang, W, Pei, D, Cheng, C, Smith, C, Landier, W, Hageman, L, Chen, Y, Yang, JJ, Crews, KR, Kornegay, N, Karol, SE, Wong, FL, Jeha, S, Sandlund, JT, Ribeiro, RC, Rubnitz, JE, Metzger, ML, Pui, C‐H, Evans, WE, Bhatia, S, Relling, MV

“…We performed a genomewide association study (GWAS) of primary erythrocyte thiopurine S‐methyltransferase (TPMT) activity in children with leukemia (n = 1,026)…”
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Pharmacogenomics and Individualized Medicine: Translating Science Into Practice by Crews, K R, Hicks, J K, Pui, C-H, Relling, M V, Evans, W E

“…Research on genes and medications has advanced our understanding of the genetic basis of individual drug responses. The aim of pharmacogenomics is to develop…”
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The Role of Inherited TPMT and COMT Genetic Variation in Cisplatin-Induced Ototoxicity in Children With Cancer by Yang, J J, Lim, J Y S, Huang, J, Bass, J, Wu, J, Wang, C, Fang, J, Stewart, E, Harstead, E H, E, S, Robinson, G W, Evans, W E, Pappo, A, Zuo, J, Relling, M V, Onar-Thomas, A, Gajjar, A, Stewart, C F

“…Ototoxicity is a debilitating side effect of platinating agents with substantial interpatient variability. We sought to evaluate the association of thiopurine…”
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A Clinician-Driven Automated System for Integration of Pharmacogenetic Interpretations Into an Electronic Medical Record by Hicks, J K, Crews, K R, Hoffman, J M, Kornegay, N M, Wilkinson, M R, Lorier, R, Stoddard, A, Yang, W, Smith, C, Fernandez, C A, Cross, S J, Haidar, C, Baker, D K, Howard, S C, Evans, W E, Broeckel, U, Relling, M V

“…Advances in pharmacogenetic testing will expand the number of clinically important pharmacogenetic variants. Communication and interpretation of these test…”
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Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia by MCLEOD, H. L, KRYNETSKI, E. Y, RELLING, M. V, EVANS, W. E

“…Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurines, including 6-mercaptopurine and 6-thioguanine. TPMT activity exhibits genetic…”
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An Inherited Genetic Variant in CEP72 Promoter Predisposes to Vincristine‐Induced Peripheral Neuropathy in Adults With Acute Lymphoblastic Leukemia by Stock, W, Diouf, B, Crews, KR, Pei, D, Cheng, C, Laumann, K, Mandrekar, SJ, Luger, S, Advani, A, Stone, RM, Larson, RA, Evans, WE

“…Peripheral neuropathy is a major toxicity of vincristine, yet no strategies exist for identifying adult patients at high‐risk. We used a case–control design of…”
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A revised definition for cure of childhood acute lymphoblastic leukemia by Pui, C H, Pei, D, Campana, D, Cheng, C, Sandlund, J T, Bowman, W P, Hudson, M M, Ribeiro, R C, Raimondi, S C, Jeha, S, Howard, S C, Bhojwani, D, Inaba, H, Rubnitz, J E, Metzger, M L, Gruber, T A, Coustan-Smith, E, Downing, J R, Leung, W H, Relling, M V, Evans, W E

“…With improved contemporary therapy, we reassess long-term outcome in patients completing treatment for childhood acute lymphoblastic leukemia (ALL) to…”
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ETV6-RUNX1-positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy by Bhojwani, D, Pei, D, Sandlund, J T, Jeha, S, Ribeiro, R C, Rubnitz, J E, Raimondi, S C, Shurtleff, S, Onciu, M, Cheng, C, Coustan-Smith, E, Bowman, W P, Howard, S C, Metzger, M L, Inaba, H, Leung, W, Evans, W E, Campana, D, Relling, M V, Pui, C-H

“…ETV6-RUNX1 fusion is the most common genetic aberration in childhood acute lymphoblastic leukemia (ALL). To evaluate whether outcomes for this drug-sensitive…”
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Warm springs reduce parasitism of the cereal leaf beetle through phenological mismatch by Evans, E. W., Carlile, N. R., Innes, M. B., Pitigala, N.

“…Variation in weather among years may affect biological control of insect pests by influencing how well matched in phenology specialist parasitoids are with…”
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Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target by Hartsink-Segers, S A, Zwaan, C M, Exalto, C, Luijendijk, M W J, Calvert, V S, Petricoin, E F, Evans, W E, Reinhardt, D, de Haas, V, Hedtjärn, M, Hansen, B R, Koch, T, Caron, H N, Pieters, R, Den Boer, M L

“…We investigated the effects of targeting the mitotic regulators aurora kinase A and B in pediatric acute lymphoblastic leukemia (ALL) and acute myeloid…”
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Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1 by Jeha, S, Pei, D, Raimondi, S C, Onciu, M, Campana, D, Cheng, C, Sandlund, J T, Ribeiro, R C, Rubnitz, J E, Howard, S C, Downing, J R, Evans, W E, Relling, M V, Pui, C-H

“…To evaluate the impact of contemporary therapy on the clinical outcome of children with pre-B acute lymphoblastic leukemia (ALL) and the t(1;19)/ TCF3/PBX1 ,…”
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Cancer Pharmacogenomics by Paugh, S W, Stocco, G, McCorkle, J R, Diouf, B, Crews, K R, Evans, W E

“…Pharmacogenomics research is yielding molecular diagnostic tools that can be used to optimize the selection of medications and their doses for individual…”
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An assessment of food safety information provision for UK chemotherapy patients to reduce the risk of foodborne infection by Evans, E.W., Redmond, E.C.

“…Given the increased risk of foodborne infection to cancer patients receiving chemotherapy treatment, and the risk of listeriosis reportedly five-times greater…”
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ARID5B SNP rs10821936 is associated with risk of childhood acute lymphoblastic leukemia in blacks and contributes to racial differences in leukemia incidence by Yang, W, Treviño, L R, Yang, J J, Scheet, P, Pui, C-H, Evans, W E, Relling, M V

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Comparison of genome sequencing and clinical genotyping for pharmacogenes by Yang, W, Wu, G, Broeckel, U, Smith, CA, Turner, V, Haidar, CE, Wang, S, Carter, R, Karol, SE, Neale, G, Crews, KR, Yang, JJ, Mullighan, CG, Downing, JR, Evans, WE, Relling, MV

“…We compared whole exome sequencing (WES, n = 176 patients) and whole genome sequencing (WGS, n = 68) and clinical genotyping (DMET array‐based approach) for…”
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