Search Results - "Evans, Dean B."

Intratumoral Estrogens and Estrogen Receptors in Human Non–Small Cell Lung Carcinoma by Niikawa, Hiromichi, Suzuki, Takashi, Miki, Yasuhiro, Suzuki, Satoshi, Nagasaki, Shuji, Akahira, Junichi, Honma, Seijiro, Evans, Dean B, Hayashi, Shin-Ichi, Kondo, Takashi, Sasano, Hironobu

“…Purpose: The possible involvement of gender-dependent factors has been suggested in human non-small cell lung carcinomas (NSCLC), but their precise roles…”
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Dual Inhibition of mTOR and Estrogen Receptor Signaling In vitro Induces Cell Death in Models of Breast Cancer by Boulay, Anne, Rudloff, Joelle, Ye, Jingjing, Zumstein-Mecker, Sabine, O'Reilly, Terence, Evans, Dean B, Chen, Shiuan, Lane, Heidi A

“…Purpose: RAD001 (everolimus), a mammalian target of rapamycin (mTOR) pathway inhibitor in phase II clinical trials in oncology, exerts potent…”
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De Novo Synthesis of Estrogen in Pregnant Uterus Is Critical for Stromal Decidualization and Angiogenesis by Das, Amrita, Mantena, Srinivasa Raju, Kannan, Athilakshmi, Evans, Dean B., Bagchi, Milan K., Bagchi, Indrani C., O'Malley, Bert W.

“…Implantation is initiated when the embryo attaches to the uterine luminal epithelium during early pregnancy. Following this event uterine stromal cells undergo…”
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Letrozole is Superior to Anastrozole in Suppressing Breast Cancer Tissue and Plasma Estrogen Levels by GEISLER, Jürgen, HELLE, Hilgegunn, EKSE, Dagfinn, DUONG, Nhat K, EVANS, Dean B, NORDBØ, Yngve, AAS, Turid, LØNNING, Per E

“…Purpose: To evaluate the influence of the third-generation aromatase inhibitor letrozole (Femara) on breast cancer tissue levels of estrone (E 1 ), estradiol…”
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Development of Steroid Signaling Pathways during Primordial Follicle Formation in the Human Fetal Ovary by Fowler, Paul A, Anderson, Richard A, Saunders, Philippa T, Kinnell, Hazel, Mason, J. Ian, Evans, Dean B, Bhattacharya, Siladitya, Flannigan, Samantha, Franks, Stephen, Monteiro, Ana, O'Shaughnessy, Peter J

“…The second trimester human fetal ovary possesses the machinery to synthesize and detect key members of the steroid signaling pathway, especially estrogenic…”
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In vivo antitumor activity of NVP-AEW541—A novel, potent, and selective inhibitor of the IGF-IR kinase by Garcı́a-Echeverrı́a, Carlos, Pearson, Mark A, Marti, Andreas, Meyer, Thomas, Mestan, Juergen, Zimmermann, Johann, Gao, Jiaping, Brueggen, Josef, Capraro, Hans-Georg, Cozens, Robert, Evans, Dean B, Fabbro, Doriano, Furet, Pascal, Porta, Diana Graus, Liebetanz, Janis, Martiny-Baron, Georg, Ruetz, Stephan, Hofmann, Francesco

“…IGF-IR-mediated signaling promotes survival, anchorage-independent growth, and oncogenic transformation, as well as tumor growth and metastasis formation in…”
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Gene Expression Profiles Differentiating Between Breast Cancers Clinically Responsive or Resistant to Letrozole by MILLER, William R, LARIONOV, Alexey, RENSHAW, Lorna, ANDERSON, Thomas J, WALKER, John R, KRAUSE, Andreas, SING, Tobias, EVANS, Dean B, DIXON, J. Michael

“…Endocrine agents, such as letrozole, are established in the treatment of hormone-dependent breast cancer. However, response rates are only 50% to 70% in the…”
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Phosphatidyl-inositol-3-kinase alpha catalytic subunit mutation and response to neoadjuvant endocrine therapy for estrogen receptor positive breast cancer by Ellis, Matthew J, Lin, Li, Crowder, Robert, Tao, Yu, Hoog, Jeremy, Snider, Jacqueline, Davies, Sherri, DeSchryver, Katherine, Evans, Dean B, Steinseifer, Jutta, Bandaru, Raj, Liu, WeiHua, Gardner, Humphrey, Semiglazov, Vladimir, Watson, Mark, Hunt, Kelly, Olson, John, Baselga, José

“…Mutations in the alpha catalytic subunit of phosphoinositol-3-kinase (PIK3CA) occur in ~30% of ER positive breast cancers. We therefore sought to determine the…”
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Letrozole Is More Effective Neoadjuvant Endocrine Therapy Than Tamoxifen for ErbB-1– and/or ErbB-2–Positive, Estrogen Receptor–Positive Primary Breast Cancer: Evidence From a Phase III Randomized Trial by ELLIS, Matthew J, COOP, Andrew, QUEBE-FEHLING, Erhard, BORGS, Mieke, SINGH, Baljit, MAURIAC, Louis, LLOMBERT-CUSSAC, Antonio, JÄNICKE, Fritz, MILLER, William R, EVANS, Dean B, DUGAN, Margaret, BRADY, Carolyn

“…Expression of ErbB-1 and ErbB-2 (epidermal growth factor receptor and HER2/neu) in breast cancer may cause tamoxifen resistance, but not all studies concur…”
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Aromatase localization in human breast cancer tissues : Possible interactions between intratumoral stromal and parenchymal cells by MIKI, Yasuhiro, SUZUKI, Takashi, OHUCHI, Noriaki, SASANO, Hironobu, TAZAWA, Chika, YAMAGUCHI, Yuri, KITADA, Kunio, HONMA, Seijiro, MORIYA, Takuya, HIRAKAWA, Hisashi, EVANS, Dean B, HAYASHI, Shin-Ichi

“…Aromatase is a key enzyme in intratumoral estrogen production required for the production of estrogens through the conversion of serum androgens in…”
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Estrogen-Independent Proliferation Is Present in Estrogen-Receptor HER2-Positive Primary Breast Cancer After Neoadjuvant Letrozole by ELLIS, Matthew J, TOO, Yu, KRAUSE, Andreas, EVANS, Dean B, MILLER, William R, DIXON, J. Michael, YOUNG, Oliver, WHITE, Sharon, PROIA, Alan D, MURRAY, Julliette, RENSHAW, Lorna, FARATIAN, Dana, THOMAS, Jeremy, DOWSETT, Mitch

“…To investigate the impact of human epidermal growth factor receptor (HER) 1 and HER2 gene amplification on endocrine therapy responsiveness, a fluorescence in…”
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Intratumoral Localization of Aromatase and Interaction between Stromal and Parenchymal Cells in the Non-Small Cell Lung Carcinoma Microenvironment by MIKI, Yasuhiro, SUZUKI, Takashi, KONDO, Takashi, YAMADA-OKABE, Hisafumi, SASANO, Hironobu, ABE, Keiko, SUZUKI, Satoshi, NIIKAWA, Hiromichi, LIDA, Shinya, HATA, Shuko, AKAHIRA, Jun-Ichi, MORI, Kazushige, EVANS, Dean B

“…Estrogens produced as a result of intratumoral aromatization has been recently shown to play important roles in proliferation of human non-small cell lung…”
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Molecular response to aromatase inhibitor treatment in primary breast cancer by Mackay, Alan, Urruticoechea, Ander, Dixon, J Michael, Dexter, Tim, Fenwick, Kerry, Ashworth, Alan, Drury, Suzanne, Larionov, Alexey, Young, Oliver, White, Sharon, Miller, William R, Evans, Dean B, Dowsett, Mitch

“…Aromatase inhibitors such as anastrozole and letrozole are highly effective suppressants of estrogen synthesis in postmenopausal women and are the most…”
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Steroid Sulfatase and Estrogen Sulfotransferase in Colon Carcinoma: Regulators of Intratumoral Estrogen Concentrations and Potent Prognostic Factors by SATO, Ryuichiro, SUZUKI, Takashi, YAMAMOTO, Kuniharu, II, Takayuki, EGAWA, Shinichi, EVANS, Dean B, UNNO, Michiaki, SASANO, Hironobu, KATAYOSE, Yu, MIURA, Koh, SHIIBA, Kenichi, TATENO, Hiroo, MIKI, Yasuhiro, AKAHIRA, Junichi, KAMOGAWA, Yukiko, NAGASAKI, Shuji

“…Previous epidemiologic and in vitro studies have indicated a potential involvement of estrogens in the pathogenesis of human colon carcinoma, but the precise…”
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Epitope characterization of an aromatase monoclonal antibody suitable for the assessment of intratumoral aromatase activity by Hong, Yanyan, Li, Hongzhi, Ye, Jingjing, Miki, Yasuhiro, Yuan, Yate-Ching, Sasano, Hironobu, Evans, Dean B, Chen, Shiuan

“…Immunohistochemistry is one of the most suitable methods for the detection of intratumoral aromatase in order to identify patients who may respond to aromatase…”
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The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer by Lisztwan, Joanna, Pornon, Astrid, Chen, Bin, Chen, Shiuan, Evans, Dean B

“…Endocrine-dependent, estrogen receptor positive breast cancer cells proliferate in response to estrogens, synthesized by the cytochrome p450 aromatase enzyme…”
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Intratumoral concentration of sex steroids and expression of sex steroid-producing enzymes in ductal carcinoma in situ of human breast by Shibuya, Rie, Suzuki, Takashi, Miki, Yasuhiro, Yoshida, Kimako, Moriya, Takuya, Ono, Katsuhiko, Akahira, Jun-ichi, Ishida, Takanori, Hirakawa, Hisashi, Evans, Dean B, Sasano, Hironobu

“…It is well known that sex steroids play important roles in the development of invasive ductal carcinoma (IDC) of the human breast. However, biological…”
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Aromatase expression and outcomes in the P024 neoadjuvant endocrine therapy trial by Ellis, Matthew J., Miller, William R., Tao, Yu, Evans, Dean B., Chaudri Ross, Hilary A., Miki, Yasuhiro, Suzuki, Takashi, Sasano, Hironobu

“…Background Expression of aromatase by malignant breast epithelial cells and/or the surrounding stroma implies local estrogen production that could influence…”
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Serum TIMP-1 and Response to the Aromatase Inhibitor Letrozole Versus Tamoxifen in Metastatic Breast Cancer by LIPTON, Allan, LEITZEL, Kim, CARNEY, Walter, CHAUDRI-ROSS, Hilary A, EVANS, Dean B, ALI, Suhail M, DEMERS, Laurence, HAMER, Peter, BROWN-SHIMER, Sheryl, PIERCE, Karen, GAUR, Victor

“…To determine the effect of elevated serum TIMP-1 on the response of patients with metastatic breast cancer to an aromatase inhibitor versus tamoxifen. Five…”
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Aromatase is phosphorylated in situ at serine-118 by Miller, Todd W., Shin, Incheol, Kagawa, Norio, Evans, Dean B., Waterman, Michael R., Arteaga, Carlos L.

“…Phosphorylation of the cytochrome P450 aromatase has been proposed as a switch to rapidly modulate enzymatic activity and estrogen biosynthesis. Herein, we…”
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