Search Results - "Evans, D. Gareth R."

Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk by Easton, Douglas F, Pharoah, Paul D.P, Antoniou, Antonis C, Tischkowitz, Marc, Tavtigian, Sean V, Nathanson, Katherine L, Devilee, Peter, Meindl, Alfons, Couch, Fergus J, Southey, Melissa, Goldgar, David E, Evans, D. Gareth R, Chenevix-Trench, Georgia, Rahman, Nazneen, Robson, Mark, Domchek, Susan M, Foulkes, William D

“…An international group of cancer geneticists review the level of evidence for the association of gene variants with the risk of breast cancer. It is difficult…”
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Cancer Surveillance in Gorlin Syndrome and Rhabdoid Tumor Predisposition Syndrome by Foulkes, William D, Kamihara, Junne, Evans, D Gareth R, Brugières, Laurence, Bourdeaut, Franck, Molenaar, Jan J, Walsh, Michael F, Brodeur, Garrett M, Diller, Lisa

“…Gorlin syndrome and rhabdoid tumor predisposition syndrome (RTPS) are autosomal dominant syndromes associated with an increased risk of childhood-onset brain…”
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Contralateral mastectomy improves survival in women with BRCA1/2-associated breast cancer by Evans, D. Gareth R., Ingham, Sarah L., Baildam, Andrew, Ross, Gary L., Lalloo, Fiona, Buchan, Iain, Howell, Anthony

“…BRCA1/2 mutation carriers with breast cancer are at high risk of contralateral disease. Such women often elect to have contralateral risk-reducing mastectomy…”
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Mammographic density adds accuracy to both the Tyrer-Cuzick and Gail breast cancer risk models in a prospective UK screening cohort by Brentnall, Adam R, Harkness, Elaine F, Astley, Susan M, Donnelly, Louise S, Stavrinos, Paula, Sampson, Sarah, Fox, Lynne, Sergeant, Jamie C, Harvie, Michelle N, Wilson, Mary, Beetles, Ursula, Gadde, Soujanya, Lim, Yit, Jain, Anil, Bundred, Sara, Barr, Nicola, Reece, Valerie, Howell, Anthony, Cuzick, Jack, Evans, D Gareth R

“…The Predicting Risk of Cancer at Screening study in Manchester, UK, is a prospective study of breast cancer risk estimation. It was designed to assess whether…”
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Cancer Screening Recommendations and Clinical Management of Inherited Gastrointestinal Cancer Syndromes in Childhood by Achatz, Maria Isabel, Porter, Christopher C, Brugières, Laurence, Druker, Harriet, Frebourg, Thierry, Foulkes, William D, Kratz, Christian P, Kuiper, Roland P, Hansford, Jordan R, Hernandez, Hector Salvador, Nathanson, Katherine L, Kohlmann, Wendy K, Doros, Leslie, Onel, Kenan, Schneider, Kami Wolfe, Scollon, Sarah R, Tabori, Uri, Tomlinson, Gail E, Evans, D Gareth R, Plon, Sharon E

“…Hereditary gastrointestinal cancer predisposition syndromes have been well characterized, but management strategies and surveillance remain a major challenge,…”
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Use of Single-Nucleotide Polymorphisms and Mammographic Density Plus Classic Risk Factors for Breast Cancer Risk Prediction by van Veen, Elke M, Brentnall, Adam R, Byers, Helen, Harkness, Elaine F, Astley, Susan M, Sampson, Sarah, Howell, Anthony, Newman, William G, Cuzick, Jack, Evans, D Gareth R

“…Single-nucleotide polymorphisms (SNPs) have demonstrated an association with breast cancer susceptibility, but there is limited evidence on how to incorporate…”
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Loss of SUFU Function in Familial Multiple Meningioma by Aavikko, Mervi, Li, Song-Ping, Saarinen, Silva, Alhopuro, Pia, Kaasinen, Eevi, Morgunova, Ekaterina, Li, Yilong, Vesanen, Kari, Smith, Miriam J., Evans, D. Gareth R., Pöyhönen, Minna, Kiuru, Anne, Auvinen, Anssi, Aaltonen, Lauri A., Taipale, Jussi, Vahteristo, Pia

“…Meningiomas are the most common primary tumors of the CNS and account for up to 30% of all CNS tumors. An increased risk of meningiomas has been associated…”
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Risk-reducing surgery increases survival in BRCA1/2 mutation carriers unaffected at time of family referral by Ingham, Sarah L., Sperrin, Matthew, Baildam, Andrew, Ross, Gary L., Clayton, Richard, Lalloo, Fiona, Buchan, Iain, Howell, Anthony, Evans, D. Gareth R.

“…The aim of this study was to establish if risk-reducing surgery (RRS) increases survival among BRCA1 / 2 carriers without breast/ovarian cancer at the time of…”
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Mortality in neurofibromatosis 1: in North West England: an assessment of actuarial survival in a region of the UK since 1989 by EVANS, D. Gareth R, O'HARA, Catherine, WILDING, Anna, INGHAM, Sarah L, HOWARD, Elizabeth, DAWSON, John, MORAN, Anthony, SCOTT-KITCHING, Vilka, HOLT, Felicity, HUSON, Susan M

“…Neurofibromatosis 1 (NF1) is a comparatively common autosomal dominant disorder. However, relatively few studies have assessed lifetime risk; and information…”
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Second Primary Tumors in Neurofibromatosis 1 Patients Treated for Optic Glioma: Substantial Risks After Radiotherapy by SHARIF, Saba, FERNER, Rosalie, BIRCH, Jillian M, GILLESPIE, James E, RAO GATTAMANENI, H, BASER, Michael E, EVANS, D. Gareth R

“…Optic pathway gliomas (OPGs) are the most common CNS tumor in neurofibromatosis 1 (NF1) patients. We evaluated the long-term risk of second tumors in…”
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Uptake of Risk-Reducing Surgery in Unaffected Women at High Risk of Breast and Ovarian Cancer Is Risk, Age, and Time Dependent by EVANS, D. Gareth R, LALLOO, Fiona, ASHCROFT, Linda, SHENTON, Andrew, CLANCY, Tara, BAILDAM, Andrew D, BRAIN, Anne, HOPWOOD, Penelope, HOWELL, Anthony

“…Purpose: The uptake of risk-reducing surgery in women at increased risk of breast and ovarian cancer is highly variable between countries and centers within…”
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Frequency of SMARCB1 mutations in familial and sporadic schwannomatosis by Smith, Miriam J., Wallace, Andrew J., Bowers, Naomi L., Rustad, Cecilie F., Woods, C. Geoff, Leschziner, Guy D., Ferner, Rosalie E., Evans, D. Gareth R.

“…Mutations of the SMARCB1 gene have been implicated in several human tumour predisposing syndromes. They have recently been identified as an underlying cause of…”
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Relative frequency and morphology of cancers in carriers of germline TP53 mutations by BIRCH, Jillian M, ALSTON, Robert D, MCNALLY, Richard J. Q, EVANS, D. Gareth R, KELSEY, Anna M, HARRIS, Martin, EDEN, Osborn B, VARLEY, Jennifer M

“…The spectrum and frequency of cancers associated with germline TP53 mutations are uncertain. To address this issue a cohort of individuals from 28 families…”
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Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome by Kratz, Christian P, Achatz, Maria Isabel, Brugières, Laurence, Frebourg, Thierry, Garber, Judy E, Greer, Mary-Louise C, Hansford, Jordan R, Janeway, Katherine A, Kohlmann, Wendy K, McGee, Rose, Mullighan, Charles G, Onel, Kenan, Pajtler, Kristian W, Pfister, Stefan M, Savage, Sharon A, Schiffman, Joshua D, Schneider, Katherine A, Strong, Louise C, Evans, D Gareth R, Wasserman, Jonathan D, Villani, Anita, Malkin, David

“…Li-Fraumeni syndrome (LFS) is an autosomal dominantly inherited condition caused by germline mutations of the tumor suppressor gene encoding p53, a…”
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Cancer and Central Nervous System Tumor Surveillance in Pediatric Neurofibromatosis 1 by Evans, D Gareth R, Salvador, Hector, Chang, Vivian Y, Erez, Ayelet, Voss, Stephan D, Schneider, Kami Wolfe, Scott, Hamish S, Plon, Sharon E, Tabori, Uri

“…Although the neurofibromatoses consist of at least three autosomal dominantly inherited disorders, neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), and…”
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Updated protocol for genetic testing, screening and clinical management of individuals at risk of NF2‐related schwannomatosis by Halliday, Dorothy, Emmanouil, Beatrice, Evans, D. Gareth R.

“…Genetic testing and management of individuals at risk for NF2‐related schwannomatosis is complicated by the high rate of mosaicism resulting in a milder, later…”
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Neurofibromatosis type 2 (NF2): a clinical and molecular review by Evans, D Gareth R

“…Neurofibromatosis type 2 (NF2) is a tumour-prone disorder characterised by the development of multiple schwannomas and meningiomas. Prevalence (initially…”
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Increasing the specificity of diagnostic criteria for schwannomatosis by BASER, Michael E, FRIEDMAN, J. M, EVANS, D. Gareth R

“…Diagnostic criteria for schwannomatosis have been proposed in a recent consensus statement. These criteria permit schwannomatosis to be distinguished from…”
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Screening for Familial Ovarian Cancer: Failure of Current Protocols to Detect Ovarian Cancer at an Early Stage According to the International Federation of Gynecology and Obstetrics System by STIRLING, Diane, EVANS, D. Gareth R, LALLOO, Fiona I, ECCLES, Diana M, LUCASSEN, Anneke M, PORTEOUS, Mary E, PICHERT, Gabriella, SHENTON, Andrew, KIRK, Elaine N, RIMMER, Sylvia, STEEL, C. Michael, LAWSON, Sheila, BUSBY-EARLE, R. M, WALKER, Jane

“…To assess the effectiveness of annual ovarian cancer screening (transvaginal ultrasound and serum CA-125 estimation) in detecting presymptomatic ovarian cancer…”
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A mechanistic mathematical model of initiation and malignant transformation in sporadic vestibular schwannoma by Paterson, Chay, Bozic, Ivana, Smith, Miriam J., Hoad, Xanthe, Evans, D. Gareth R.

“…Background A vestibular schwannoma (VS) is a relatively rare, benign tumour of the eighth cranial nerve, often involving alterations to the gene NF2 . Previous…”
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