Search Results - "Evans, Bronwyn A."

Adrenoceptors in white, brown, and brite adipocytes by Evans, Bronwyn A., Merlin, Jon, Bengtsson, Tore, Hutchinson, Dana S.

“…Adrenoceptors play an important role in adipose tissue biology and physiology that includes regulating the synthesis and storage of triglycerides…”
Get full text

Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue by Chia, Ling Yeong, Evans, Bronwyn A., Mukaida, Saori, Bengtsson, Tore, Hutchinson, Dana S., Sato, Masaaki

“…A vital role of adrenoceptors in metabolism and energy balance has been well documented in the heart, skeletal muscle, and adipose tissue. It has been only…”
Get full text

Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations by Civciristov, Srgjan, Ellisdon, Andrew M, Suderman, Ryan, Pon, Cindy K, Evans, Bronwyn A, Kleifeld, Oded, Charlton, Steven J, Hlavacek, William S, Canals, Meritxell, Halls, Michelle L

“…G protein-coupled receptors (GPCRs) are the largest class of cell surface signaling proteins, participate in nearly all physiological processes, and are the…”
Get more information

Factors influencing biased agonism in recombinant cells expressing the human α1A‐adrenoceptor by Silva Junior, Edilson Dantas, Sato, Masaaki, Merlin, Jon, Broxton, Natalie, Hutchinson, Dana S, Ventura, Sabatino, Evans, Bronwyn A, Summers, Roger J

“…Background and Purpose Agonists acting at GPCRs promote biased signalling via Gα or Gβγ subunits, GPCR kinases and β‐arrestins. Since the demonstration of…”
Get full text

Signal transduction pathways activated by insulin‐like peptide 5 at the relaxin family peptide RXFP4 receptor by Ang, Sheng Y, Hutchinson, Dana S, Patil, Nitin, Evans, Bronwyn A, Bathgate, Ross A D, Halls, Michelle L, Hossain, Mohammed A, Summers, Roger J, Kocan, Martina

“…Background and Purpose Insulin‐like peptide 5 (INSL5) is a two‐chain, three‐disulfide‐bonded peptide of the insulin/relaxin superfamily, uniquely expressed in…”
Get full text

Rosiglitazone and a β3-Adrenoceptor Agonist Are Both Required for Functional Browning of White Adipocytes in Culture by Merlin, Jon, Sato, Masaaki, Chia, Ling Yeong, Fahey, Richard, Pakzad, Mohsen, Nowell, Cameron J., Summers, Roger J., Bengtsson, Tore, Evans, Bronwyn A., Hutchinson, Dana S.

“…The recruitment of brite (or beige) adipocytes has been advocated as a means to combat obesity, due to their ability to phenotypically resemble brown…”
Get full text

Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake by Ham, Seungmin, Mukaida, Saori, Sato, Masaaki, Keov, Peter, Bengtsson, Tore, Furness, Sebastian, Holliday, Nicholas D., Evans, Bronwyn A., Summers, Roger J., Hutchinson, Dana S.

“…Truncation of the C‐terminal tail of the β2‐AR, transfection of βARKct or over‐expression of a kinase‐dead GRK mutant reduces isoprenaline‐stimulated glucose…”
Get full text

Does the autonomic nervous system contribute to the initiation and progression of prostate cancer by Ventura, Sabatino, Evans, Bronwyn A

“…In the July 12 issue of Science maga-zine, researchers from the AlbertEinstein College of Medicine, the Mount Sinai School of Medicine, the Durham VA Medical…”
Get full text

The M3-muscarinic acetylcholine receptor stimulates glucose uptake in L6 skeletal muscle cells by a CaMKK-AMPK-dependent mechanism by Merlin, Jon, Evans, Bronwyn A, Csikasz, Robert I, Bengtsson, Tore, Summers, Roger J, Hutchinson, Dana S

“…The role of muscarinic acetylcholine receptors (mAChRs) in regulating glucose uptake in L6 skeletal muscle cells was investigated. [(3)H]-2-Deoxyglucose uptake…”
Get full text

Orthosteric binding of ρ-Da1a, a natural peptide of snake venom interacting selectively with the α1A-adrenoceptor by Maïga, Arhamatoulaye, Merlin, Jon, Marcon, Elodie, Rouget, Céline, Larregola, Maud, Gilquin, Bernard, Fruchart-Gaillard, Carole, Lajeunesse, Evelyne, Marchetti, Charles, Lorphelin, Alain, Bellanger, Laurent, Summers, Roger J, Hutchinson, Dana S, Evans, Bronwyn A, Servent, Denis, Gilles, Nicolas

“…ρ-Da1a is a three-finger fold toxin from green mamba venom that is highly selective for the α1A-adrenoceptor. This toxin has atypical pharmacological…”
Get full text

Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis by Merlin, Jon, Evans, Bronwyn A, Dehvari, Nodi, Sato, Masaaki, Bengtsson, Tore, Hutchinson, Dana S

“…There are two types of adipose tissue with distinct functions—white adipose tissue stores chemical energy as triglycerides, whereas brown adipose tissue…”
Get full text

Adrenoceptors promote glucose uptake into adipocytes and muscle by an insulin-independent signaling pathway involving mechanistic target of rapamycin complex 2 by Mukaida, Saori, Evans, Bronwyn A., Bengtsson, Tore, Hutchinson, Dana S., Sato, Masaaki

“…[Display omitted] Mechanism of β-AR mediated glucose uptake in skeletal muscle and brown adipocytes β2-AR in skeletal muscle and β3-AR in brown adipocytes are…”
Get full text

Ligand‐directed signalling at β‐adrenoceptors by Evans, Bronwyn A., Sato, Masaaki, Sarwar, Mohsin, Hutchinson, Dana S., Summers, Roger J.

“…β‐Adrenoceptors (ARs) classically mediate responses to the endogenous ligands adrenaline and noradrenaline by coupling to Gsα and stimulating cAMP production;…”
Get full text

The PPARγ agonist rosiglitazone promotes the induction of brite adipocytes, increasing β-adrenoceptor-mediated mitochondrial function and glucose uptake by Merlin, Jon, Sato, Masaaki, Nowell, Cameron, Pakzad, Mohsen, Fahey, Richard, Gao, Jie, Dehvari, Nodi, Summers, Roger J., Bengtsson, Tore, Evans, Bronwyn A., Hutchinson, Dana S.

“…Recruitment and activation of brite (or beige) adipocytes has been advocated as a potential avenue for manipulating whole-body energy expenditure. Despite…”
Get full text

Multiple signalling pathways involved in β 2 ‐adrenoceptor‐mediated glucose uptake in rat skeletal muscle cells by Nevzorova, Julia, Evans, Bronwyn A, Bengtsson, Tore, Summers, Roger J

“…β ‐adrenoceptor (AR) agonists increase 2‐deoxy‐[ 3 H]‐ D ‐glucose uptake (GU) via β 2 ‐AR in rat L6 cells. The β ‐AR agonists, zinterol ( β 2 ‐AR) and…”
Get full text

Upregulation of β3-adrenoceptors—a general marker of and protective mechanism against hypoxia? by Dal Monte, Massimo, Evans, Bronwyn A., Arioglu-Inan, Ebru, Michel, Martin C.

“…β 3 -Adrenoceptors exhibit a restricted expression pattern, particularly in humans. However, they have been found to be upregulated in various cancers and…”
Get full text

α1A-Adrenoceptors activate mTOR signalling and glucose uptake in cardiomyocytes by Sato, Masaaki, Evans, Bronwyn A., Sandström, Anna L., Chia, Ling Yeong, Mukaida, Saori, Thai, Bui San, Nguyen, Anh, Lim, Linzi, Tan, Christina Y.R., Baltos, Jo-Anne, White, Paul J., May, Lauren T., Hutchinson, Dana S., Summers, Roger J., Bengtsson, Tore

“…[Display omitted] The capacity of G protein-coupled receptors to modulate mechanistic target of rapamycin (mTOR) activity is a newly emerging paradigm with the…”
Get full text

Role of G protein-coupled receptor kinases (GRKs) in β 2 -adrenoceptor-mediated glucose uptake by Ham, Seungmin, Mukaida, Saori, Sato, Masaaki, Keov, Peter, Bengtsson, Tore, Furness, Sebastian, Holliday, Nicholas D, Evans, Bronwyn A, Summers, Roger J, Hutchinson, Dana S

“…Truncation of the C-terminal tail of the β -AR, transfection of βARKct or over-expression of a kinase-dead GRK mutant reduces isoprenaline-stimulated glucose…”
Get full text

INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells by Ang, Sheng Y, Evans, Bronwyn A, Poole, Daniel P, Bron, Romke, DiCello, Jesse J, Bathgate, Ross A D, Kocan, Martina, Hutchinson, Dana S, Summers, Roger J

“…Insulin-like peptide 5 (INSL5) is a newly discovered gut hormone expressed in colonic enteroendocrine L-cells but little is known about its biological…”
Get full text

Stereoselectivity for interactions of agonists and antagonists at mouse, rat and human β3-adrenoceptors by POPP, Ben D, HUTCHINSON, Dana S, EVANS, Bronwyn A, SUMMERS, Roger J

Get full text