Search Results - "Evanno, Gwenaelle"
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Potential deleterious role of anti-Neu5Gc antibodies in xenotransplantation
Published in Xenotransplantation (Københaven) (01-03-2015)“…Human beings do not synthesize the glycolyl form of the sialic acid (Neu5Gc) and only express the acetylated form of the sugar, whereas a diet‐based intake of…”
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Anti-SARS-CoV-2 glyco-humanized polyclonal antibody XAV-19: phase II/III randomized placebo-controlled trial shows acceleration to recovery for mild to moderate patients with COVID-19
Published in Frontiers in immunology (17-04-2024)“…XAV-19 is a glyco-humanized swine polyclonal antibody targeting SARS-CoV-2 with high neutralizing activity. The safety and clinical efficacy of XAV-19 were…”
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Eukaryotic Control on Bacterial Cell Cycle and Differentiation in the Rhizobium-legume Symbiosis
Published in Proceedings of the National Academy of Sciences - PNAS (28-03-2006)“…Symbiosis between legumes and Rhizobium bacteria leads to the formation of root nodules where bacteria in the infected plant cells are converted into…”
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XAV-19, a Swine Glyco-Humanized Polyclonal Antibody Against SARS-CoV-2 Spike Receptor-Binding Domain, Targets Multiple Epitopes and Broadly Neutralizes Variants
Published in Frontiers in immunology (15-11-2021)“…Amino acid substitutions and deletions in the Spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants can reduce the…”
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LIS1, a glyco-humanized swine polyclonal anti-lymphocyte globulin, as a novel induction treatment in solid organ transplantation
Published in Frontiers in immunology (16-02-2023)“…Anti-thymocyte or anti-lymphocyte globulins (ATGs/ALGs) are immunosuppressive drugs used in induction therapies to prevent acute rejection in solid organ…”
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High neutralizing potency of swine glyco‐humanized polyclonal antibodies against SARS‐CoV‐2
Published in European journal of immunology (01-06-2021)“…Heterologous polyclonal antibodies might represent an alternative to the use of convalescent plasma or monoclonal antibodies (mAbs) in coronavirus disease…”
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In Vivo Analysis of Human Immune Responses in Immunodeficient Rats
Published in Transplantation (01-04-2020)“…BACKGROUND.Humanized immune system immunodeficient mice have been extremely useful for the in vivo analyses of immune responses in a variety of models,…”
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Anti-Gal and Anti-Neu5Gc Responses in Nonimmunosuppressed Patients After Treatment With Rabbit Antithymocyte Polyclonal IgGs
Published in Transplantation (01-10-2017)“…BACKGROUNDPolyclonal antihuman thymocyte rabbit IgGs (antithymocyte globulin [ATG]) are popular immunosuppressive drugs used to prevent or treat organ or…”
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Rabbit antithymocyte globulin-induced serum sickness disease and human kidney graft survival
Published in The Journal of clinical investigation (01-12-2015)“…Rabbit-generated antithymocyte globulins (ATGs), which target human T cells, are widely used as immunosuppressive agents during treatment of kidney allograft…”
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An integrated 4249 marker FISH/RH map of the canine genome
Published in BMC genomics (13-09-2004)“…The 156 breeds of dog recognized by the American Kennel Club offer a unique opportunity to map genes important in genetic variation. Each breed features a…”
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Corrigendum: XAV-19, a swine glyco-humanized polyclonal antibody against SARS-CoV-2 spike receptor-binding domain, targets multiple epitopes and broadly neutralizes variants
Published in Frontiers in immunology (28-04-2023)“…[This corrects the article DOI: 10.3389/fimmu.2021.761250.]…”
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Quantitative and qualitative changes in anti‐Neu5Gc antibody response following rabbit anti‐thymocyte IgG induction in kidney allograft recipients
Published in European journal of clinical investigation (01-04-2019)“…Antibodies of non‐human mammals are glycosylated with carbohydrate antigens, such as galactose‐α‐1‐3‐galactose (α‐Gal) and N‐glycolylneuraminic acid (Neu5Gc)…”
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First-in-human Study With LIS1, a Next-generation Porcine Low Immunogenicity Antilymphocyte Immunoglobulin in Kidney Transplantation
Published in Transplantation (01-07-2024)“…Polyclonal rabbit antithymocyte globulins (ATGs) are commonly used in organ transplantation as induction. Anti- N -glycolylneuraminic acid carbohydrate…”
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Anti-EBOV GP IgGs Lacking α1-3-Galactose and Neu5Gc Prolong Survival and Decrease Blood Viral Load in EBOV-Infected Guinea Pigs
Published in PloS one (2016)“…Polyclonal xenogenic IgGs, although having been used in the prevention and cure of severe infectious diseases, are highly immunogenic, which may restrict their…”
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Abstract 2737: LIS22, a first in class polyclonal antibody immunotherapy in T cell blood cancers
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Background: Several approaches such as antibody drug conjugate (ADC), chimeric antigen receptor T cells (CAR-T) and recently bispecific antibodies are being…”
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Abstract 2738: XON7, a new Glyco-Humanized Polyclonal Antibody, first in class immunotherapy against several solid tumors
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Introduction: Cancer immunotherapy has recently generated much excitement after the success of the immunomodulating anti-CTLA-4 and anti-PD-1 antibodies…”
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First-in-human Study With LIS1, a Next-generation Porcine Low Immunogenicity Antilymphocyte Immunoglobulin in Kidney Transplantation
Published in Transplantation (01-07-2024)“…Polyclonal rabbit antithymocyte globulins (ATGs) are commonly used in organ transplantation as induction. Anti- N -glycolylneuraminic acid carbohydrate…”
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Identification of a gene expression profile associated with operational tolerance among a selected group of stable kidney transplant patients
Published in Transplant international (01-06-2011)“…Despite their utility, immunosuppressive treatments have numerous side effects, including infectious complications, malignancies and metabolic disorders, all…”
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Facilitating genome navigation: survey sequencing and dense radiation-hybrid gene mapping
Published in Nature reviews. Genetics (01-08-2005)“…Accurate and comprehensive sequence coverage for large genomes has been restricted to only a few species of specific interest. Lower sequence coverage (survey…”
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