Search Results - "Eva, Richard"

The Virtuous Cycle of Axon Growth: Axonal Transport of Growth‐Promoting Machinery as an Intrinsic Determinant of Axon Regeneration by Petrova, Veselina, Eva, Richard

“…ABSTRACT Injury to the brain and spinal cord has devastating consequences because adult central nervous system (CNS) axons fail to regenerate. Injury to the…”
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Axon transport as a target for promoting RGC survival and optic nerve regeneration by Eva, Richard

“…Adult CNS neurons have a weak intrinsic capacity for regeneration after injury, but the underlying cellular mechanisms preventing regeneration are not…”
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Promoting axon regeneration in the central nervous system by increasing PI3-kinase signaling by Nieuwenhuis, Bart, Eva, Richard

“…Much research has focused on the PI3-kinase and PTEN signaling pathway with the aim to stimulate repair of the injured central nervous system. Axons in the…”
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EFA6 regulates selective polarised transport and axon regeneration from the axon initial segment by Eva, Richard, Koseki, Hiroaki, Kanamarlapudi, Venkateswarlu, Fawcett, James W

“…Central nervous system (CNS) axons lose their intrinsic ability to regenerate upon maturity, whereas peripheral nervous system (PNS) axons do not. A key…”
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Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS by Petrova, Veselina, Pearson, Craig S., Ching, Jared, Tribble, James R., Solano, Andrea G., Yang, Yunfei, Love, Fiona M., Watt, Robert J., Osborne, Andrew, Reid, Evan, Williams, Pete A., Martin, Keith R., Geller, Herbert M., Eva, Richard, Fawcett, James W.

“…Adult mammalian central nervous system axons have intrinsically poor regenerative capacity, so axonal injury has permanent consequences. One approach to…”
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Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury by Petrova, Veselina, Nieuwenhuis, Bart, Fawcett, James W, Eva, Richard

“…Investigating the molecular mechanisms governing developmental axon growth has been a useful approach for identifying new strategies for boosting axon…”
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Dysregulated Cell Homeostasis and miRNAs in Human iPSC-Derived Cardiomyocytes from a Propionic Acidemia Patient with Cardiomyopathy by Álvarez, Mar, Ruiz-Sala, Pedro, Pérez, Belén, Desviat, Lourdes Ruiz, Richard, Eva

“…Propionic acidemia (PA) disorder shows major involvement of the heart, among other alterations. A significant number of PA patients develop cardiac…”
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Selective rab11 transport and the intrinsic regenerative ability of CNS axons by Koseki, Hiroaki, Donegá, Matteo, Lam, Brian Yh, Petrova, Veselina, van Erp, Susan, Yeo, Giles Sh, Kwok, Jessica Cf, Ffrench-Constant, Charles, Eva, Richard, Fawcett, James W

“…Neurons lose intrinsic axon regenerative ability with maturation, but the mechanism remains unclear. Using an in-vitro laser axotomy model, we show a…”
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PI 3‐kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS by Nieuwenhuis, Bart, Barber, Amanda C, Evans, Rachel S, Pearson, Craig S, Fuchs, Joachim, MacQueen, Amy R, van Erp, Susan, Haenzi, Barbara, Hulshof, Lianne A, Osborne, Andrew, Conceicao, Raquel, Khatib, Tasneem Z, Deshpande, Sarita S, Cave, Joshua, Ffrench‐Constant, Charles, Smith, Patrice D, Okkenhaug, Klaus, Eickholt, Britta J, Martin, Keith R, Fawcett, James W, Eva, Richard

“…Peripheral nervous system (PNS) neurons support axon regeneration into adulthood, whereas central nervous system (CNS) neurons lose regenerative ability after…”
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Role of miRNAs in human disease and inborn errors of metabolism by Rivera-Barahona, Ana, Pérez, Belén, Richard, Eva, Desviat, Lourdes R.

“…MicroRNAs (miRNAs) are short, noncoding RNAs that regulate gene expression posttranscriptionally by base pairing with target messenger RNAs (mRNAs). They are…”
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Regional Regulation of Purkinje Cell Dendritic Spines by Integrins and Eph/Ephrins by Heintz, Tristan G, Eva, Richard, Fawcett, James W

“…Climbing fibres and parallel fibres compete for dendritic space on Purkinje cells in the cerebellum. Normally, climbing fibres populate the proximal dendrites,…”
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Cardiomyocytes Derived from Induced Pluripotent Stem Cells as a Disease Model for Propionic Acidemia by Alonso-Barroso, Esmeralda, Pérez, Belén, Desviat, Lourdes Ruiz, Richard, Eva

“…Propionic acidemia (PA), one of the most frequent life-threatening organic acidemias, is caused by mutations in either the or genes encoding both subunits of…”
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Linking axon transport to regeneration using in vitro laser axotomy by Nieuwenhuis, Bart, Eva, Richard

“…Integrins are cell surface receptors for ECM molecules that mediate axon growth during CNS development and adult peripheral nervous system (PNS) regeneration…”
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Rab11 and Its Effector Rab Coupling Protein Contribute to the Trafficking of β1 Integrins during Axon Growth in Adult Dorsal Root Ganglion Neurons and PC12 Cells by Eva, Richard, Dassie, Elisa, Caswell, Patrick T., Dick, Gunnar, ffrench-Constant, Charles, Norman, Jim C., Fawcett, James W.

“…Integrins play an important part in axon growth, but integrin traffic in neurons is poorly understood. Expression of the tenascin-C-binding integrin α9…”
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Metabolic Rewiring and Altered Glial Differentiation in an iPSC-Derived Astrocyte Model Derived from a Nonketotic Hyperglycinemia Patient by Arribas-Carreira, Laura, Castro, Margarita, García, Fernando, Navarrete, Rosa, Bravo-Alonso, Irene, Zafra, Francisco, Ugarte, Magdalena, Richard, Eva, Pérez, Belén, Rodríguez-Pombo, Pilar

“…The pathophysiology of nonketotic hyperglycinemia (NKH), a rare neuro-metabolic disorder associated with severe brain malformations and life-threatening…”
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O-GlcNAcylation enhances CPS1 catalytic efficiency for ammonia and promotes ureagenesis by Soria, Leandro R., Makris, Georgios, D’Alessio, Alfonso M., De Angelis, Angela, Boffa, Iolanda, Pravata, Veronica M., Rüfenacht, Véronique, Attanasio, Sergio, Nusco, Edoardo, Arena, Paola, Ferenbach, Andrew T., Paris, Debora, Cuomo, Paola, Motta, Andrea, Nitzahn, Matthew, Lipshutz, Gerald S., Martínez-Pizarro, Ainhoa, Richard, Eva, Desviat, Lourdes R., Häberle, Johannes, van Aalten, Daan M. F., Brunetti-Pierri, Nicola

“…Life-threatening hyperammonemia occurs in both inherited and acquired liver diseases affecting ureagenesis, the main pathway for detoxification of neurotoxic…”
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Exclusion of integrins from CNS axons is regulated by Arf6 activation and the AIS by Franssen, Elske H P, Zhao, Rong-Rong, Koseki, Hiroaki, Kanamarlapudi, Venkateswarlu, Hoogenraad, Casper C, Eva, Richard, Fawcett, James W

“…Integrins are adhesion and survival molecules involved in axon growth during CNS development, as well as axon regeneration after injury in the peripheral…”
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Cardiac Complications of Propionic and Other Inherited Organic Acidemias by Park, Kyung Chan, Krywawych, Steve, Richard, Eva, Desviat, Lourdes R, Swietach, Pawel

“…Clinical observations and experimental studies have determined that systemic acid-base disturbances can profoundly affect the heart. A wealth of information is…”
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Endoplasmic Reticulum Stress and Autophagy in Homocystinuria Patients with Remethylation Defects by Martínez-Pizarro, Ainhoa, Desviat, Lourdes R, Ugarte, Magdalena, Pérez, Belén, Richard, Eva

“…Proper function of endoplasmic reticulum (ER) and mitochondria is crucial for cellular homeostasis, and dysfunction at either site as well as perturbation of…”
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Regulating PCCA gene expression by modulation of pseudoexon splicing patterns to rescue enzyme activity in propionic acidemia by Spangsberg Petersen, Ulrika Simone, Dembic, Maja, Martínez-Pizarro, Ainhoa, Richard, Eva, Holm, Lise Lolle, Havelund, Jesper Foged, Doktor, Thomas Koed, Larsen, Martin Røssel, Færgeman, Nils J., Desviat, Lourdes Ruiz, Andresen, Brage Storstein

“…Pseudoexons are nonfunctional intronic sequences that can be activated by deep-intronic sequence variation. Activation increases pseudoexon inclusion in mRNA…”
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