Search Results - "European journal of pharmacology. Molecular pharmacology section"

Comparative functional properties of two structurally similar selective nonpeptide drug-like ligands for the angiotensin II type-2 (AT2) receptor. Effects on neurite outgrowth in NG108-15 cells by Guimond, Marie-Odile, Wallinder, Charlotta, Alterman, Mathias, Hallberg, Anders, Gallo-Payet, Nicole

“…There is increasing evidence that angiotensin II (Ang II), through binding to the type 2 (AT2) receptor may have beneficial effects in various physiological…”
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Involvement of tryptophan W276 and of two surrounding amino acid residues in the high constitutive activity of the ghrelin receptor GHS-R1a by Gozé, Catherine, Bergé, Gilbert, M'Kadmi, Céline, Floquet, Nicolas, Gagne, Didier, Galleyrand, Jean-Claude, Fehrentz, Jean-Alain, Martinez, Jean

“…The human ghrelin receptor (GHS-R1a) is known to display a high level of signaling in the absence of ligand. The Trp276, located in the fully conserved CWXP…”
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Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition by Laurie, D J, Seeburg, P H

“…The ligand preferences of recombinant NR1 homomeric and NR1-NR2 heteromeric NMDA receptors were examined by homogenate binding assay. The binding affinities…”
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Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands by Rupprecht, R, Reul, J M, van Steensel, B, Spengler, D, Söder, M, Berning, B, Holsboer, F, Damm, K

“…We characterized the pharmacological profiles of the human mineralocorticoid and glucocorticoid receptor for 11 natural and synthetic steroids regarding…”
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Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine by Eaton, S A, Jane, D E, Jones, P L, Porter, R H, Pook, P C, Sunter, D C, Udvarhelyi, P M, Roberts, P J, Salt, T E, Watkins, J C

“…Two phenylglycine derivates, (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine, competitively antagonised…”
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NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices by Garthwaite, J, Garthwaite, G, Palmer, R M, Moncada, S

“…Activation of N-methyl-D-aspartate (NMDA) receptors in rat cerebellum leads to the release of endothelium-derived relaxing factor, now identified as nitric…”
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Characterisation of [3H]gabapentin binding to a novel site in rat brain: homogenate binding studies by Suman-Chauhan, N, Webdale, L, Hill, D R, Woodruff, G N

“…The binding characteristics of [3H]gabapentin, the radiolabelled analogue of the novel anticonvulsant gabapentin (1-(aminomethyl)cyclohexaneacetic acid) were…”
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The selective 5-HT1A antagonist radioligand [3H]WAY 100635 labels both G-protein-coupled and free 5-HT1A receptors in rat brain membranes by GOZLAN, H, THIBAULT, S, LAPORTE, A.-M, LIMA, L, HAMON, M

“…The tritiated derivative of the novel silent 5-HT1A receptor antagonist WAY 100635 [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl) cyclohexane…”
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(Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor by Butt, E, Eigenthaler, M, Genieser, H G

“…In the present study, the inhibitory effect of the cGMP analog (Rp)-8-(para-chlorophenylthio)guanosine-3',5'-cyclic monophosphorothioate ((Rp)-8-pCPT-cGMPS) on…”
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Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures by Pike, C J, Walencewicz, A J, Glabe, C G, Cotman, C W

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Characterisation of melanocortin receptor subtypes by radioligand binding analysis by Schiöth, Helgi B., Muceniece, Ruta, Wikberg, Jarl E.S., Chhajlani, Vijay

“…The DNAs encoding three melanocortin receptor subtypes (melanocortin MC 1 receptor, melanocortin MC 3 receptor and melanocortin MC 5 receptor) were expressed…”
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Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family by Thomsen, C, Boel, E, Suzdak, P D

“…The functional effects of phenylglycine analogs on metabotropic glutamate receptor (mGluR) subtypes mGluR1 alpha, mGluR2 and mGluR4 were examined…”
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The concept of selectivity in 5-HT receptor research by van Wijngaarden, I, Tulp, M T, Soudijn, W

“…Since the demonstration that serotonin (5-hydroxytryptamine, 5-HT) interacts with different (sub)types of membrane receptors, several compounds have been…”
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MPTP mechanisms of neurotoxicity and their implications for Parkinson's disease by Gerlach, M, Riederer, P, Przuntek, H, Youdim, M B

“…Systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) gives rise to motor deficits in humans and other primates which closely resemble…”
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Cytoprotective effect of NMDA receptor antagonists on prion protein (PrionSc)-induced toxicity in rat cortical cell cultures by Müller, W E, Ushijima, H, Schröder, H C, Forrest, J M, Schatton, W F, Rytik, P G, Heffner-Lauc, M

“…Rat cortical cells were incubated with the Scrapie prion protein, PrionSc. At concentrations of 3 ng/ml of PrionSc and higher, the viability of the cells…”
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Desensitization, phosphorylation and palmitoylation of the human dopamine D1 receptor by Ng, G Y, Mouillac, B, George, S R, Caron, M, Dennis, M, Bouvier, M, O'Dowd, B F

“…The regulation and post-translational modifications of the human dopamine D1 receptor were studied in the baculovirus-eukaryotic cell expression system…”
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Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study by Kornhuber, J, Bormann, J, Hübers, M, Rusche, K, Riederer, P

“…Recent studies from our laboratory have provided evidence that the 1-amino-adamantane derivative memantine (1-amino-3,5-dimethyl-adamantane) binds to the…”
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Physostigmine, galanthamine and codeine act as ‘noncompetitive nicotinic receptor agonists’ on clonal rat pheochromocytoma cells by Storch, Alexander, Schrattenholz, André, Cooper, Julia C., Ghani, El Moeiz Abdel, Gutbrod, Oliver, Weber, Karl-Heinz, Reinhardt, Sigrid, Lobron, Christina, Hermsen, Bernhard, Šoškiç, Vukiç, Pereira, Edna F.R., Albuquerque, Edson X., Methfessel, Christoph, Maelicke, Alfred

“…The acetylcholine esterase inhibitor (−)-physostigmine has been shown to act as agonist on nicotinic acetylcholine receptors from muscle and brain, by binding…”
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Site-directed mutagenesis of the human dopamine D2 receptor by Mansour, A, Meng, F, Meador-Woodruff, J H, Taylor, L P, Civelli, O, Akil, H

“…Based on amino acid sequence and computer modeling, two conflicting three-dimensional models of the dopamine D2 receptor have been proposed. One model (Dahl et…”
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Characterization of the binding of [3H](+)-pentazocine to sigma recognition sites in guinea pig brain by DeHaven-Hudkins, D L, Fleissner, L C, Ford-Rice, F Y

“…The selective sigma compound (+)-pentazocine was radiolabeled and its binding characteristics in guinea pig brain membranes were investigated…”
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