Search Results - "European journal of pharmaceutical sciences"

Antimicrobial resistance: Prevalence, economic burden, mechanisms of resistance and strategies to overcome by Pulingam, Thiruchelvi, Parumasivam, Thaigarajan, Gazzali, Amirah Mohd, Sulaiman, Azlinah Mohd, Chee, Jiun Yee, Lakshmanan, Manoj, Chin, Chai Fung, Sudesh, Kumar

“…Antibiotic resistance is a major health concern globally and has been estimated to cause 10 million deaths worldwide by year 2050 if the current trend of…”
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Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review by Vinarov, Zahari, Abdallah, Mohammad, Agundez, José A.G., Allegaert, Karel, Basit, Abdul W., Braeckmans, Marlies, Ceulemans, Jens, Corsetti, Maura, Griffin, Brendan T., Grimm, Michael, Keszthelyi, Daniel, Koziolek, Mirko, Madla, Christine M., Matthys, Christophe, McCoubrey, Laura E., Mitra, Amitava, Reppas, Christos, Stappaerts, Jef, Steenackers, Nele, Trevaskis, Natalie L., Vanuytsel, Tim, Vertzoni, Maria, Weitschies, Werner, Wilson, Clive, Augustijns, Patrick

“…The absorption of oral drugs is frequently plagued by significant variability with potentially serious therapeutic consequences. The source of variability can…”
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Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems by Boyd, Ben J., Bergström, Christel A.S., Vinarov, Zahari, Kuentz, Martin, Brouwers, Joachim, Augustijns, Patrick, Brandl, Martin, Bernkop-Schnürch, Andreas, Shrestha, Neha, Préat, Véronique, Müllertz, Anette, Bauer-Brandl, Annette, Jannin, Vincent

“…Poorly water-soluble drugs continue to be a problematic, yet important class of pharmaceutical compounds for treatment of a wide range of diseases. Their…”
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Autophagy as a molecular target for cancer treatment by Kocaturk, Nur Mehpare, Akkoc, Yunus, Kig, Cenk, Bayraktar, Oznur, Gozuacik, Devrim, Kutlu, Ozlem

“…Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells recycle or degrades internal constituents through membrane-trafficking…”
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A molecular docking study repurposes FDA approved iron oxide nanoparticles to treat and control COVID-19 infection by Abo-zeid, Yasmin, Ismail, Nasser S.M., McLean, Gary R., Hamdy, Nadia M.

“…COVID-19, is a disease resulting from the SARS-CoV-2 global pandemic. Due to the current global emergency and the length of time required to develop specific…”
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The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group by Koziolek, Mirko, Alcaro, Stefano, Augustijns, Patrick, Basit, Abdul W., Grimm, Michael, Hens, Bart, Hoad, Caroline L., Jedamzik, Philipp, Madla, Christine M., Maliepaard, Marc, Marciani, Luca, Maruca, Annalisa, Parrott, Neil, Pávek, Petr, Porter, Christopher J.H., Reppas, Christos, van Riet-Nales, Diana, Rubbens, Jari, Statelova, Marina, Trevaskis, Natalie L., Valentová, Kateřina, Vertzoni, Maria, Čepo, Dubravka Vitali, Corsetti, Maura

“…The simultaneous intake of food and drugs can have a strong impact on drug release, absorption, distribution, metabolism and/or elimination and consequently,…”
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Indoles — A promising scaffold for drug development by Sravanthi, T.V., Manju, S.L.

“…Generally, heterocycles occupy a prominent place in chemistry due to their wide range of applications in the fields of drug design, photochemistry,…”
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Impact of gastrointestinal physiology on drug absorption in special populations––An UNGAP review by Stillhart, Cordula, Vučićević, Katarina, Augustijns, Patrick, Basit, Abdul W., Batchelor, Hannah, Flanagan, Talia R., Gesquiere, Ina, Greupink, Rick, Keszthelyi, Daniel, Koskinen, Mikko, Madla, Christine M., Matthys, Christophe, Miljuš, Goran, Mooij, Miriam G., Parrott, Neil, Ungell, Anna-Lena, de Wildt, Saskia N., Orlu, Mine, Klein, Sandra, Müllertz, Anette

“…The release and absorption profile of an oral medication is influenced by the physicochemical properties of the drug and its formulation, as well as by the…”
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Drug transport mechanisms and in vitro release kinetics of vancomycin encapsulated chitosan-alginate polyelectrolyte microparticles as a controlled drug delivery system by Unagolla, Janitha M., Jayasuriya, Ambalangodage C.

“…In this study, chitosan-alginate polyelectrolyte microparticles containing the antibiotic, vancomycin chloride were prepared using the ionotropic gelation…”
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Interpreting non-linear drug diffusion data: Utilizing Korsmeyer-Peppas model to study drug release from liposomes by Wu, Iren Yeeling, Bala, Sonali, Škalko-Basnet, Nataša, di Cagno, Massimiliano Pio

“…The aim of this work was to clarify the dynamics behind the influence of ionic strength on the changes in drug release from large unilamellar vesicles (LUVs)…”
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Formulations based on solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for cutaneous use: A review by Garcês, A., Amaral, M.H., Sousa Lobo, J.M., Silva, A.C.

“…Cutaneous use of lipid nanoparticles (solid lipid nanoparticles, SLN and nanostructured lipid carriers, NLC) has been showing promising results. These systems…”
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Digital light processing (DLP) 3D-printing technology and photoreactive polymers in fabrication of modified-release tablets by Kadry, Hossam, Wadnap, Soham, Xu, Changxue, Ahsan, Fakhrul

“…In this study, we assessed the feasibility of using digital light processing (DLP) 3D printers (3DP) in fabrication of solid oral dosage forms. The DLP…”
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Chitosan-based nanosystems and their exploited antimicrobial activity by Perinelli, Diego Romano, Fagioli, Laura, Campana, Raffaella, Lam, Jenny K.W., Baffone, Wally, Palmieri, Giovanni Filippo, Casettari, Luca, Bonacucina, Giulia

“…Chitosan is a biodegradable and biocompatible natural polysaccharide that has a wide range of applications in the field of pharmaceutics, biomedical, chemical,…”
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Spray drying of pharmaceuticals and biopharmaceuticals: Critical parameters and experimental process optimization approaches by Ziaee, Ahmad, Albadarin, Ahmad B., Padrela, Luis, Femmer, Tim, O'Reilly, Emmet, Walker, Gavin

“…Spray drying is increasingly becoming recognized as an efficient drying and formulation technique for pharmaceutical and biopharmaceutical processing. It…”
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Clinical Outcomes and Plasma Concentrations of Baloxavir Marboxil and Favipiravir in COVID-19 Patients: An Exploratory Randomized, Controlled Trial by Lou, Yan, Liu, Lin, Yao, Hangping, Hu, Xingjiang, Su, Junwei, Xu, Kaijin, Luo, Rui, Yang, Xi, He, Lingjuan, Lu, Xiaoyang, Zhao, Qingwei, Liang, Tingbo, Qiu, Yunqing

“…•An exploratory randomized, controlled trial of baloxavir marboxil and favipiravir in COVID-19 patients were conducted.•The free drug concentrations of…”
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Recent advances in polymeric micelles for anti-cancer drug delivery by Biswas, Swati, Kumari, Preeti, Lakhani, Prit Manish, Ghosh, Balaram

“…Block co-polymeric micelles receive increased attention due to their ability to load therapeutics, deliver the cargo to the site of action, improve the…”
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Localised and sustained intradermal delivery of methotrexate using nanocrystal-loaded microneedle arrays: Potential for enhanced treatment of psoriasis by Tekko, Ismaiel A., Permana, Andi Dian, Vora, Lalitkumar, Hatahet, Taher, McCarthy, Helen O., Donnelly, Ryan F.

“…•We developed methotrexate nanocrystals for its localising and sustaining its release in at the application site in the skin.•We incorporated the nanocrystals…”
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Fabrication of extended-release patient-tailored prednisolone tablets via fused deposition modelling (FDM) 3D printing by Skowyra, Justyna, Pietrzak, Katarzyna, Alhnan, Mohamed A.

“…[Display omitted] Rapid and reliable tailoring of the dose of controlled release tablets to suit an individual patient is a major challenge for personalized…”
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An insight into the therapeutic applications of coumarin compounds and their mechanisms of action by Garg, Sourbh Suren, Gupta, Jeena, Sharma, Shikha, Sahu, Debasis

“…•Coumarins are heterocyclic compounds belonging to the class of benzopyrone enriched in various plants.•Coumarins and their derivatives exert…”
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Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review by Vertzoni, Maria, Augustijns, Patrick, Grimm, Michael, Koziolek, Mirko, Lemmens, Glenn, Parrott, Neil, Pentafragka, Christina, Reppas, Christos, Rubbens, Jari, Van Den Αbeele, Jens, Vanuytsel, Tim, Weitschies, Werner, Wilson, Clive G.

“…Oral administration is the most common route of drug delivery. The absorption of a drug from the gut into the bloodstream involves disintegration of the solid…”
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