Search Results - "European journal of medicinal chemistry"

Exploring the new horizons of drug repurposing: A vital tool for turning hard work into smart work by Kumar, Rajesh, Harilal, Seetha, Gupta, Sheeba Varghese, Jose, Jobin, Thomas Parambi, Della Grace, Uddin, Md. Sahab, Shah, Muhammad Ajmal, Mathew, Bijo

“…Drug discovery and development are long and financially taxing processes. On an average it takes 12–15 years and costs 1.2 billion USD for successful drug…”
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Oxidative stress mitigation by antioxidants - An overview on their chemistry and influences on health status by Pisoschi, Aurelia Magdalena, Pop, Aneta, Iordache, Florin, Stanca, Loredana, Predoi, Gabriel, Serban, Andreea Iren

“…The present review paper focuses on the chemistry of oxidative stress mitigation by antioxidants. Oxidative stress is understood as a lack of balance between…”
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Current trends in computer aided drug design and a highlight of drugs discovered via computational techniques: A review by Sabe, Victor T., Ntombela, Thandokuhle, Jhamba, Lindiwe A., Maguire, Glenn E.M., Govender, Thavendran, Naicker, Tricia, Kruger, Hendrik G.

“…Computer-aided drug design (CADD) is one of the pivotal approaches to contemporary pre-clinical drug discovery, and various computational techniques and…”
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Medicinal prospects of antioxidants: A review by Neha, Kumari, Haider, Md Rafi, Pathak, Ankita, Yar, M. Shahar

“…Free radicals generated due to exposure of radiation, environmental pollutants and as by-products of metabolised drugs. These free radicals are antagonized by…”
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1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships by Xu, Zhi, Zhao, Shi-Jia, Liu, Yi

“…Anticancer agents are critical for the cancer treatment, but side effects and the drug resistance associated with the currently used anticancer agents create…”
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Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview by Mondal, Subha, Adhikari, Nilanjan, Banerjee, Suvankar, Amin, Sk Abdul, Jha, Tarun

“…Matrix metalloproteinases (MMPs) are zinc dependent proteolytic metalloenzyme. MMP-9 is one of the most complex forms of matrix metalloproteinases. MMP-9 has…”
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β-lactam antibiotics: An overview from a medicinal chemistry perspective by Lima, Lidia Moreira, Silva, Bianca Nascimento Monteiro da, Barbosa, Gisele, Barreiro, Eliezer J.

“…β-Lactam antibiotics are one of the most relevant drug classes of antibacterial agents worldwide. The discovery and the market of first β-lactam antibiotic…”
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Indole: A privileged scaffold for the design of anti-cancer agents by Wan, Yichao, Li, Yuanhua, Yan, Chunxing, Yan, Mi, Tang, Zilong

“…In general, heterocyclic compounds are a significant source of pharmacologically active compounds. Among them, the indole scaffold widely distributes in…”
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Alzheimer’s disease and its treatment by different approaches: A review by Srivastava, Sukriti, Ahmad, Razi, Khare, Sunil Kumar

“…Alzheimer’s disease (AD) is a neurodegenerative disorder that impairs mental ability development and interrupts neurocognitive function. This neuropathological…”
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The therapeutic potential of curcumin: A review of clinical trials by Salehi, Bahare, Stojanović-Radić, Zorica, Matejić, Jelena, Sharifi-Rad, Mehdi, Anil Kumar, Nanjangud V., Martins, Natália, Sharifi-Rad, Javad

“…Curcuma longa L., its derived extracts and even its major compound curcumin has a long history of use and doubtless effectiveness, reported through…”
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Composition design and medical application of liposomes by Li, Mingyuan, Du, Chunyang, Guo, Na, Teng, Yuou, Meng, Xin, Sun, Hua, Li, Shuangshuang, Yu, Peng, Galons, Hervé

“…Liposomes, which possess the properties of nano-scale, biofilm similar structure, excellent biocompatibility, become more and more useful in the drug…”
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Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review by Zhao, Chuang, Rakesh, K.P., Ravidar, L., Fang, Wan-Yin, Qin, Hua-Li

“…Sulfur (SVI) based moieties, especially, the sulfonyl or sulfonamide based analogues have showed a variety of pharmacological properties, and its derivatives…”
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Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review by Wang, Wanying, Zhou, Hua, Liu, Liang

“…Methotrexate (MTX) is used as an anchor disease-modifying anti-rheumatic drugs (DMARDs) in treating rheumatoid arthritis (RA) because of its potent efficacy…”
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Thiazole-containing compounds as therapeutic targets for cancer therapy by Sharma, Prabodh Chander, Bansal, Kushal Kumar, Sharma, Archana, Sharma, Diksha, Deep, Aakash

“…In the last few decades, considerable progress has been made in anticancer agents development, and several new anticancer agents of natural and synthetic…”
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Role of sulphur-heterocycles in medicinal chemistry: An update by Pathania, Shelly, Narang, Raj Kumar, Rawal, Ravindra K.

“…From many decades, S-heterocycles have maintained their status as an important part and core of FDA approved drugs and medicinally active compounds. With…”
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Role of PPAR receptor in different diseases and their ligands: Physiological importance and clinical implications by Mirza, Agha Zeeshan, Althagafi, Ismail I., Shamshad, Hina

“…The peroxisome proliferator-activated receptors (PPAR-α, PPAR-β/δ, and PPAR-γ) are members of the nuclear receptor super-family, acting as ligand-inducible…”
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The role of antioxidants in the chemistry of oxidative stress: A review by Pisoschi, Aurelia Magdalena, Pop, Aneta

“…This Review Article is focused on the action of the reactive oxygenated species in inducing oxidative injury of the lipid membrane components, as well as on…”
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Therapeutic potential of quercetin as a cardiovascular agent by Patel, Rahul V., Mistry, Bhupendra M., Shinde, Surendra K., Syed, Riyaz, Singh, Vijay, Shin, Han-Seung

“…Flavonoids are integral components of various vegetation and in foods; consequently, they represent an inevitable part of the diet. Historical and…”
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Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view by Chadha, Navriti, Silakari, Om

“…Indoles constitute extensively explored heterocyclic ring systems with wide range of applications in pathophysiological conditions that is, cancer, microbial…”
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An insight on medicinal attributes of 1,2,4-triazoles by Aggarwal, Ranjana, Sumran, Garima

“…The present review aims to summarize the pharmacological profile of 1,2,4-triazole, one of the emerging privileged scaffold, as antifungal, antibacterial,…”
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