Search Results - "European journal of biochemistry"

The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis by Brunk, Ulf T, Terman, Alexei

“…Cellular manifestations of aging are most pronounced in postmitotic cells, such as neurons and cardiac myocytes. Alterations of these cells, which are…”
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Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis by Zhao, Ming, Antunes, Fernando, Eaton, John W., Brunk, Ulf T.

“…Exposure of mammalian cells to oxidant stress causes early (iron catalysed) lysosomal rupture followed by apoptosis or necrosis. Enhanced intracellular…”
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Multistep synthesis of a novel copper complex with potential for Alzheimer’s disease diagnosis by Dellal, Fatma, Santo Domingo Porqueras, Diego, Narayanin-Richenapin, Stacy, Thimotee, Marine, Delahaye, Vanessa, Diouf, Yacine, Piasta, Karolina, Gumienna-Kontecka, Elżbieta, Kozlowski, Henryk, Beyler, Maryline, Tripier, Raphael, Moyeux, Alban, Gager, Olivier, Besnard, Valérie, Salerno, Milena

“…Positron emission tomography (PET) imaging of Aβ plaques, is recognized as a tool for the diagnosis of Alzheimer’s disease. As a contribution to the…”
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Peroxidase activity of rice (Oryza sativa) hemoglobin: distinct role of tyrosines 112 and 151 by Derrien, Valérie, André, Eric, Bernad, Sophie

“…Five non-symbiotic hemoglobins (nsHb) have been identified in rice ( Oryza sativa ). Previous studies have shown that stress conditions can induce their…”
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Structure of human follicle-stimulating hormone in complex with its receptor by Fan, Qing R, Hendrickson, Wayne A

“…Follicle-stimulating hormone (FSH) is central to reproduction in mammals. It acts through a G-protein-coupled receptor on the surface of target cells to…”
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Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients by Iwamoto, Takuji, Okamoto, Hiroshi, Toyama, Yoshiaki, Momohara, Shigeki

“…Rheumatoid arthritis (RA) is a chronic symmetric polyarticular joint disease that primarily affects the small joints of the hands and feet. The inflammatory…”
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Apoptosis signaling by death receptors by Schulze‐Osthoff, Klaus, Ferrari, Davide, Los, Marek, Wesselborg, Sebastian, Peter, Marcus E.

“…Death receptors have been recently identified as a subgroup of the TNF‐receptor superfamily with a predominant function in induction of apoptosis. The…”
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Antisense technologies. Improvement through novel chemical modifications by Kurreck, Jens

“…Antisense agents are valuable tools to inhibit the expression of a target gene in a sequence-specific manner, and may be used for functional genomics, target…”
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The mystery of nonclassical protein secretion. A current view on cargo proteins and potential export routes by Nickel, Walter

“…Most of the examples of protein translocation across a membrane (such as the import of classical secretory proteins into the endoplasmic reticulum, import of…”
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A novel pathway for sequential transformation of 7‐dehydrocholesterol and expression of the P450scc system in mammalian skin by Slominski, Andrzej, Zjawiony, Jordan, Wortsman, Jacobo, Semak, Igor, Stewart, Jeremy, Pisarchik, Alexander, Sweatman, Trevor, Marcos, Josep, Dunbar, Chuck, C. Tuckey, Robert

“…Following up on our previous findings that the skin possesses steroidogenic activity from progesterone, we now show widespread cutaneous expression of the full…”
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Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity by O'Brien, John, Wilson, Ian, Orton, Terry, Pognan, François

“…We show here the identity of Alamar Blue as resazurin. The ‘resazurin reduction test’ has been used for about 50 years to monitor bacterial and yeast…”
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Physiological functions of thioredoxin and thioredoxin reductase by Arnér, Elias S. J., Holmgren, Arne

“…Thioredoxin, thioredoxin reductase and NADPH, the thioredoxin system, is ubiquitous from Archea to man. Thioredoxins, with a dithiol/disulfide active site…”
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Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels by Van Der Stelt, Mario, Di Marzo, Vincenzo

“…Endovanilloids are defined as endogenous ligands of the transient receptor potential vanilloid type 1 (TRPV1) protein, a nonselective cation channel that…”
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What does it mean to be natively unfolded? by Uversky, Vladimir N.

“…Natively unfolded or intrinsically unstructured proteins constitute a unique group of the protein kingdom. The evolutionary persistence of such proteins…”
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Solution structure of the Alzheimer amyloid β‐peptide (1–42) in an apolar microenvironment: Similarity with a virus fusion domain by Crescenzi, Orlando, Tomaselli, Simona, Guerrini, Remo, Salvadori, Severo, D'Ursi, Anna M, Temussi, Piero Andrea, Picone, Delia

“…The major components of neuritic plaques found in Alzheimer disease (AD) are peptides known as amyloid β‐peptides (Aβ), which derive from the proteolitic…”
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Post‐translational modifications and activation of p53 by genotoxic stresses by Appella, Ettore, Anderson, Carl W.

“…In unstressed cells, the tumor suppressor protein p53 is present in a latent state and is maintained at low levels through targeted degradation. A variety of…”
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Identification of crucial residues for the antibacterial activity of the proline‐rich peptide, pyrrhocoricin by Kragol, Goran, Hoffmann, Ralf, Chattergoon, Michael A., Lovas, Sandor, Cudic, Mare, Bulet, Philippe, Condie, Barry A., Rosengren, K. Johan, Montaner, Luis J., Otvos, Laszlo

“…Members of the proline‐rich antibacterial peptide family, pyrrhocoricin, apidaecin and drosocin appear to kill responsive bacterial species by binding to the…”
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Properties of the prophenoloxidase activating enzyme of the freshwater crayfish, Pacifastacus leniusculus by Wang, Ruigong, Lee, So Young, Cerenius, Lage, Söderhäll, Kenneth

“…The prophenoloxidase activating enzyme (ppA), a serine proteinase catalyzing the conversion of prophenoloxidase to an active phenoloxidase, has a molecular…”
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Biochemical pharmacology of the vanilloid receptor TRPV1. An update by Cortright, Daniel N, Szallasi, Arpad

“…There is mounting evidence that the vanilloid (capsaicin) receptor; transient receptor potential channel, vanilloid subfamily member 1 (TRPV1), is subjected to…”
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Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease by Bras, Jose, Singleton, Andrew, Cookson, Mark R, Hardy, John

“…Heterozygous loss-of-function mutations at the glucosecerebrosidase locus have recently been shown to be a potent risk factor for Lewy body disease. Based on…”
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