Search Results - "Eunice Zhang, J"

A Randomized Trial of Genotype-Guided Dosing of Warfarin by Pirmohamed, Munir, Burnside, Girvan, Eriksson, Niclas, Jorgensen, Andrea L, Toh, Cheng Hock, Nicholson, Toby, Kesteven, Patrick, Christersson, Christina, Wahlström, Bengt, Stafberg, Christina, Zhang, J. Eunice, Leathart, Julian B, Kohnke, Hugo, Maitland-van der Zee, Anke H, Williamson, Paula R, Daly, Ann K, Avery, Peter, Kamali, Farhad, Wadelius, Mia

“…This trial compared genotype-guided dosing with standard dosing in patients with atrial fibrillation or venous thromboembolism initiating warfarin…”
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Warfarin dosing algorithms: A systematic review by Asiimwe, Innocent G., Zhang, Eunice J., Osanlou, Rostam, Jorgensen, Andrea L., Pirmohamed, Munir

“…Aims Numerous algorithms have been developed to guide warfarin dosing and improve clinical outcomes. We reviewed the algorithms available for various…”
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A multi-factorial analysis of response to warfarin in a UK prospective cohort by Bourgeois, Stephane, Jorgensen, Andrea, Zhang, Eunice J, Hanson, Anita, Gillman, Matthew S, Bumpstead, Suzannah, Toh, Cheng Hock, Williamson, Paula, Daly, Ann K, Kamali, Farhad, Deloukas, Panos, Pirmohamed, Munir

“…Warfarin is the most widely used oral anticoagulant worldwide, but it has a narrow therapeutic index which necessitates constant monitoring of anticoagulation…”
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Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study by Jorgensen, Andrea L, Prince, Clare, Fitzgerald, Gail, Hanson, Anita, Downing, Jennifer, Reynolds, Julia, Zhang, J Eunice, Alfirevic, Ana, Pirmohamed, Munir

“…Warfarin is a widely used oral anticoagulant. Determining the correct dose required to maintain the international normalised ratio (INR) within a therapeutic…”
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A genome-wide association study of plasma concentrations of warfarin enantiomers and metabolites in sub-Saharan black-African patients by Asiimwe, Innocent G., Blockman, Marc, Cohen, Karen, Cupido, Clint, Hutchinson, Claire, Jacobson, Barry, Lamorde, Mohammed, Morgan, Jennie, Mouton, Johannes P., Nakagaayi, Doreen, Okello, Emmy, Schapkaitz, Elise, Sekaggya-Wiltshire, Christine, Semakula, Jerome R., Waitt, Catriona, Zhang, Eunice J., Jorgensen, Andrea L., Pirmohamed, Munir

“…Diversity in pharmacogenomic studies is poor, especially in relation to the inclusion of black African patients. Lack of funding and difficulties in…”
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Stable warfarin dose prediction in sub‐Saharan African patients: A machine‐learning approach and external validation of a clinical dose–initiation algorithm by Asiimwe, Innocent G., Blockman, Marc, Cohen, Karen, Cupido, Clint, Hutchinson, Claire, Jacobson, Barry, Lamorde, Mohammed, Morgan, Jennie, Mouton, Johannes P., Nakagaayi, Doreen, Okello, Emmy, Schapkaitz, Elise, Sekaggya‐Wiltshire, Christine, Semakula, Jerome R., Waitt, Catriona, Zhang, Eunice J., Jorgensen, Andrea L., Pirmohamed, Munir

“…Warfarin remains the most widely prescribed oral anticoagulant in sub‐Saharan Africa. However, because of its narrow therapeutic index, dosing can be…”
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Genome-Wide association between EYA1 and Aspirin-induced peptic ulceration by Bourgeois, Stephane, Carr, Daniel F., Musumba, Crispin O., Penrose, Alexander, Esume, Celestine, Morris, Andrew P., Jorgensen, Andrea L., Zhang, J. Eunice, Pritchard, D. Mark, Deloukas, Panos, Pirmohamed, Munir

“…Low-dose aspirin can cause gastric and duodenal ulceration, hereafter called peptic ulcer disease (PUD). Predisposition is thought to be related to clinical…”
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DPYD genetic polymorphisms in non-European patients with severe fluoropyrimidine-related toxicity: a systematic review by Chan, Tsun Ho, Zhang, J. Eunice, Pirmohamed, Munir

“…Background Pre-treatment DPYD screening is mandated in the UK and EU to reduce the risk of severe and potentially fatal fluoropyrimidine-related toxicity. Four…”
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Being precise with anticoagulation to reduce adverse drug reactions: are we there yet? by Cross, Benjamin, Turner, Richard M., Zhang, J. Eunice, Pirmohamed, Munir

“…Anticoagulants are potent therapeutics widely used in medical and surgical settings, and the amount spent on anticoagulation is rising. Although warfarin…”
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Genetic Factors Influencing Warfarin Dose in Black‐African Patients: A Systematic Review and Meta‐Analysis by Asiimwe, Innocent G., Zhang, Eunice J., Osanlou, Rostam, Krause, Amanda, Dillon, Chrisly, Suarez‐Kurtz, Guilherme, Zhang, Honghong, Perini, Jamila A., Renta, Jessicca Y., Duconge, Jorge, Cavallari, Larisa H., Marcatto, Leiliane R., Beasly, Mark T., Perera, Minoli A., Limdi, Nita A., Santos, Paulo C.J.L., Kimmel, Stephen E., Lubitz, Steven A., Scott, Stuart A., Kawai, Vivian K., Jorgensen, Andrea L., Pirmohamed, Munir

“…Warfarin is the most commonly used oral anticoagulant in sub‐Saharan Africa. Dosing is challenging due to a narrow therapeutic index and high interindividual…”
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Developing and Validating a Clinical Warfarin Dose‐Initiation Model for Black‐African Patients in South Africa and Uganda by Asiimwe, Innocent G., Waitt, Catriona, Sekaggya‐Wiltshire, Christine, Hutchinson, Claire, Okello, Emmy, Zhang, Eunice J., Semakula, Jerome R., Mouton, Johannes P., Cohen, Karen, Blockman, Marc, Lamorde, Mohammed, Jorgensen, Andrea L., Pirmohamed, Munir

“…Warfarin remains the oral anticoagulant of choice in sub‐Saharan Africa. However, dosing is challenging due to a highly variable clinical response for a given…”
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Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study by Hawcutt, Daniel B, Francis, Ben, Carr, Daniel F, Jorgensen, Andrea L, Yin, Peng, Wallin, Naomi, O'Hara, Natalie, Zhang, Eunice J, Bloch, Katarzyna M, Ganguli, Amitava, Thompson, Ben, McEvoy, Laurence, Peak, Matthew, Crawford, Andrew A, Walker, Brian R, Blair, Joanne C, Couriel, Jonathan, Smyth, Rosalind L, Pirmohamed, Munir

“…A serious adverse effect of corticosteroid therapy is adrenal suppression. Our aim was to identify genetic variants affecting susceptibility to…”
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Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients by McCormack, Mark, Gui, Hongsheng, Ingason, Andrés, Speed, Doug, Wright, Galen E.B, Zhang, Eunice J, Secolin, Rodrigo, Yasuda, Clarissa, Kwok, Maxwell, Wolking, Stefan, Becker, Felicitas, Rau, Sarah, Avbersek, Andreja, Heggeli, Kristin, Leu, Costin, Depondt, Chantal, Sills, Graeme J, Marson, Anthony G, Auce, Pauls, Brodie, Martin J, Francis, Ben, Johnson, Michael R, Koeleman, Bobby P.C, Striano, Pasquale, Coppola, Antonietta, Zara, Federico, Kunz, Wolfram S, Sander, Josemir W, Lerche, Holger, Klein, Karl Martin, Weckhuysen, Sarah, Krenn, Martin, Gudmundsson, Lárus J, Stefánsson, Kári, Krause, Roland, Shear, Neil, Ross, Colin J.D, Delanty, Norman, Pirmohamed, Munir, Carleton, Bruce C, Cendes, Fernando, Lopes-Cendes, Iscia, Liao, Wei-ping, OʼBrien, Terence J, Sisodiya, Sanjay M, Cherny, Stacey, Kwan, Patrick, Baum, Larry, Cavalleri, Gianpiero L

“…OBJECTIVETo characterize, among European and Han Chinese populations, the genetic predictors of maculopapular exanthema (MPE), a cutaneous adverse drug…”
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Genetic associations with clozapine-induced myocarditis in patients with schizophrenia by Lacaze, Paul, Ronaldson, Kathlyn J., Zhang, Eunice J., Alfirevic, Ana, Shah, Hardik, Newman, Leah, Strahl, Maya, Smith, Melissa, Bousman, Chad, Francis, Ben, Morris, Andrew P., Wilson, Trevor, Rossello, Fernando, Powell, David, Vasic, Vivien, Sebra, Robert, McNeil, John J., Pirmohamed, Munir

“…Clozapine is the most effective antipsychotic drug for schizophrenia, yet it can cause life-threatening adverse drug reactions, including myocarditis. The aim…”
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Meta-analysis of genome-wide association studies of stable warfarin dose in patients of African ancestry by Asiimwe, Innocent G., Blockman, Marc, Cavallari, Larisa H., Cohen, Karen, Cupido, Clint, Dandara, Collet, Davis, Brittney H., Jacobson, Barry, Johnson, Julie A., Lamorde, Mohammed, Limdi, Nita A., Morgan, Jennie, Mouton, Johannes P., Muyambo, Sarudzai, Nakagaayi, Doreen, Ndadza, Arinao, Okello, Emmy, Perera, Minoli A., Schapkaitz, Elise, Sekaggya-Wiltshire, Christine, Semakula, Jerome R., Tatz, Gayle, Waitt, Catriona, Yang, Guang, Zhang, Eunice J., Jorgensen, Andrea L., Pirmohamed, Munir

“…•The CYP2C and VKORC1 loci are the most important in determining warfarin dose requirements in individuals of African ancestry.•We identified a biologically…”
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Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry by Alfirevic, Ana, Durocher, Jill, Elati, Anisa, León, Wilfrido, Dickens, David, Rädisch, Steffen, Box, Helen, Siccardi, Marco, Curley, Paul, Xinarianos, George, Ardeshana, Arjun, Owen, Andrew, Zhang, J Eunice, Pirmohamed, Munir, Alfirevic, Zarko, Weeks, Andrew, Winikoff, Beverly

“…Misoprostol, a prostaglandin analogue used for the treatment of postpartum hemorrhage and termination of pregnancy, can cause high fevers. Genetic…”
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Is the interleukin 8 promoter polymorphism rs4073/-251T >A associated with Clostridium difficile infection? by Miyajima, Fabio, Swale, Andrew, Zhang, J Eunice, Alfirevic, Ana, Little, Margaret, Beeching, Nicholas J, Smith, Godfrey, Kolamunnage-Dona, Ruwanthi, Pirmohamed, Munir

“…The interleukin 8 gene single-nucleotide polymorphism rs4073/-251T >A predisposes to Clostridium difficile infection (CDI), but this association has not been…”
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SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses by Wang, Beibei, Skelly, Donal, Pan, Daniel, Omo-Dare, Nicola, Koeckerling, David, Jenkin, Daniel, Fernandes da Costa, Cristiano, Malik, Tariq, Baillie, J. Kenneth, Klenerman, Paul, Pollard, Andrew J., Conlon, Christopher, Jeffery, Katie, Stafford, Lizzie, Chand, Meera, Green, Christoper A., Harrison, Ewen M., Wai Ho, Antonia Ying, Palmarini, Massimo, Price, Nicholas, Robertson, David L., Sigfrid, Louise, Sriskandan, Shiranee, Stuart, David, Swann, Olivia V., Tedder, Richard S., Turtle, Lance CW, Zambon, Maria, Pius, Riinu, Knight, Stephen R., Harrison, Janet, Jackson, Clare, Gamble, Carrol, Plotkin, Daniel, Lee, James, Wham, Murray, Shaw, Victoria, McDonald, Sarah E., Armstrong, Jane A., Ashworth, Milton, Barlow, Samantha L., Bullock, Katie, Davis, Christopher, Dunn, Chris, King, Katharine, Kiy, Robyn T., Lant, Suzannah, Latawiec, Diane, Mancini, Maria, Metelmann, Soeren, Penrice-Randal, Rebekah, Pilgrim, Jack, van Tonder, Libby, Murphy, Lee, Morrice, Kirstie, Gilchrist, Tammy, Aldera, Erin L., Barnass, Stella, Bernatoniene, Jolanta, Bothma, Pieter, Brittain-Long, Robin, Caruth, Vikki, Collini, Paul, Dawson, Chris, Dervisevic, Samir, Dushianthan, Ahilanadan, Evans, Cariad, Harvey, Daniel, Hawcutt, Daniel B., Hodgson, Luke, Hormis, Anil, Kerrison, Caroline, Larkin, Susan, Little, Jeff, Meda, Manjula, Moon, James, Mortimore, Katherine, Murphy, Michael, O’Shea, Matthew K., Otahal, Igor, Panchatsharam, Selva, Patel, Brij, Pepperell, Justin, Peters, Mark, Price, David, Reschreiter, Henrik, Ruge, Bobby, Saluja, Taranprit, Sizer, Jeremy, Shankar-Hari, Manu, Snelson, Catherine, Staines, Nikki, Twagira, Mary, Vincent-Smith, Lisa, Visuvanathan, Shico, Welters, Ingeborg, Wolverson, Adam, Yates, Bryan, Fry, Elizabeth E., Ren, Jingshan

“…On 24th November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B.1.1.529 was announced, containing far more mutations in Spike (S) than…”
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Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study by Halpin, Sophie, Donohue, Chloe, Ladhani, Shamez, Horby, Peter W, Docherty, Annemarie B, Semple, Malcolm G, Openshaw, Peter J M, Bach, Benjamin, Chand, Meera, Harrison, Ewen M, Hiscox, Julian A, Horby, Peter W, Klenerman, Paul, Law, Andrew, Moore, Shona C, Palmarini, Massimo, Russell, Clark D, Solomon, Tom, Sriskandan, Shiranee, Stuart, David, Thomson, Emma C, Oosthuyzen, Wilna, Norman, Lisa, Pius, Riinu, Mclean, Kenneth A, Saviciute, Egle, Leeming, Gary, Hendry, Ross, Greenhalf, William, Ahmed, Katie A, Asiimwe, Innocent G, Brennan, Benjamin, Catterall, Benjamin WA, Clark, Jordan J, Cole, Sarah, Cox, Helen, Elliott, Angela, Foster, Terry, Greenhalf, Willliam, Jones, Trevor R, Murphy, Ellen G, Small, Benjamin, Subramaniam, Krishanthi S, Tanianis, Jolanta, Trochu, Erwan, van Tonder, Libby, Wilcock, Eve, Agranoff, Daniel, Angus, Brian, Atkinson, Dougal, Barlow, Gavin, Barrett, Nicholas, Bassford, Christopher, Beadsworth, Michael, Best, Nicola, Burden, Tom, Chukkambotla, Srikanth, Cupitt, Jason, Dark, Paul, Dushianthan, Ahilanadan, Dyer, Tristan, Evans, Cariad, Fegan, Christopher, Finn, Adam, Fullerton, Duncan, Goldsmith, Arthur, Hardy, Elaine, Havalda, Peter, Holme, Anita, Kendall, Jason, Kerrison, Caroline, Larkin, Susan, Leiner, Tamas, Lillie, Patrick, MacNaughton, Emily, McCullough, Katherine, Moore, Elinoor, Morgan, Patrick, Morris, Craig, Nelson, Mark, Panchatsharam, Selva, Pintus, Stefania, Prout, Rachel, Rousseau, Guy, Ryan, Brendan, Saluja, Taranprit, Shanmuga, Prad, Sharma, Anil, Sizer, Jeremy, Smith, Richard, Snelson, Catherine, Spittle, Nick, Stambach, Tom, Tridente, Ascanio, Ustianowski, Andrew, Waddy, Sam, Whittaker, Paul, Williams, Martin, Wiselka, Martin, Young, Peter

“…AbstractObjectiveTo characterise the clinical features of children and young people admitted to hospital with laboratory confirmed severe acute respiratory…”
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Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study by Knight, Stephen R, Holden, Karl A, Merson, Laura, Russell, Clark D, Solomon, Tom, Carson, Gail, Olliaro, Piero, Semple, Malcolm G, Alex, Beatrice, Bach, Benjamin, Dunning, Jake, da Silva Filipe, Ana, Horby, Peter W, Law, Andrew, Price, Nicholas, Rambaut, Andrew, Robertson, David L, Scott, Janet T, de Silva, Thushan, Sigfrid, Louise, Tedder, Richard S, Thwaites, Ryan S, Turtle, Lance CW, Andrikopoulos, Petros, Liggi, Sonia, Sands, Caroline, Fairfield, Cameron J, Shaw, Catherine A, Dalton, Jo, Girvan, Michelle, Hendry, Ross, Greenhalf, William, McDonald, Sarah E, Booth, Laura, Catterall, Benjamin WA, Clarke, Emily A, Dincarslan, Oslem, Dyer, Philip, Gunning, Philip, Hartley, Catherine, Jensen, Rebecca L, Jones, Christopher B, Khandaker, Shadia, Lefteri, Daniella, Livoti, Lucia A, Middleton, Joanna, Reynolds, Will, Ridley, P. Matthew, Shaw, Victoria E, Tanianis-Hughes, Jolanta, Trochu, Erwan, Flaherty, Lisa, Massey, Hannah, Aldera, Erin L., Alegria, Ana, Barnass, Stella, Barrett, Nicholas, Basude, Sneha, Baxter, David, Beadsworth, Michael, Best, Nicola, Burden, Tom, Chukkambotla, Srikanth, Cutino-Moguel, Maria-Teresa, Douthwaite, Sam, Fullerton, Duncan, Garg, Atul, Hawcutt, Daniel B, Jennings, Paul, Kaliappan, Agilan, Kasipandian, Vidya, Koduri, Gouri, Laird, Steven, Leiner, Tamas, Little, Jeff, McEwen, Ruth, Morris, Craig, Moses, Samuel, Norris, Lillian, Panchatsharam, Selva, Pattison, Natalie, Peters, Mark, Price, David, Prout, Rachel, Richardson, Neil, Rousseau, Guy, Ryan, Brendan, Sharma, Anil, Stambach, Tom, Stewart, Richard, Thompson, Robert, Tridente, Ascanio, Vuylsteke, Alan, Waddy, Sam, Wake, Rachel, Wilson, Lawrence, Wiselka, Martin, Wootton, Daniel G, Workman, Andrew, Young, Peter

“…COVID-19 is a multisystem disease and patients who survive might have in-hospital complications. These complications are likely to have important short-term…”
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