Search Results - "Eum, Hye Hyeon"

Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer by Chung, Woosung, Eum, Hye Hyeon, Lee, Hae-Ock, Lee, Kyung-Min, Lee, Han-Byoel, Kim, Kyu-Tae, Ryu, Han Suk, Kim, Sangmin, Lee, Jeong Eon, Park, Yeon Hee, Kan, Zhengyan, Han, Wonshik, Park, Woong-Yang

“…Single-cell transcriptome profiling of tumour tissue isolates allows the characterization of heterogeneous tumour cells along with neighbouring stromal and…”
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Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma by Kim, Nayoung, Kim, Hong Kwan, Lee, Kyungjong, Hong, Yourae, Cho, Jong Ho, Choi, Jung Won, Lee, Jung-Il, Suh, Yeon-Lim, Ku, Bo Mi, Eum, Hye Hyeon, Choi, Soyean, Choi, Yoon-La, Joung, Je-Gun, Park, Woong-Yang, Jung, Hyun Ae, Sun, Jong-Mu, Lee, Se-Hoon, Ahn, Jin Seok, Park, Keunchil, Ahn, Myung-Ju, Lee, Hae-Ock

“…Advanced metastatic cancer poses utmost clinical challenges and may present molecular and cellular features distinct from an early-stage cancer. Herein, we…”
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Alternative polyadenylation of single cells delineates cell types and serves as a prognostic marker in early stage breast cancer by Kim, Nayoung, Chung, Woosung, Eum, Hye Hyeon, Lee, Hae-Ock, Park, Woong-Yang

“…Alternative polyadenylation (APA) in 3' untranslated regions (3' UTR) plays an important role in regulating transcript abundance, localization, and interaction…”
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Prescreening of tumor samples for tumor-centric transcriptome analyses of lung adenocarcinoma by Kim, Nayoung, Jeong, Dasom, Jo, Areum, Eum, Hye Hyeon, Lee, Hae-Ock

“…Abstract Background Single-cell RNA sequencing (scRNA-seq) enables the systemic assessment of intratumoral heterogeneity within tumor cell populations and in…”
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Tumor-promoting macrophages prevail in malignant ascites of advanced gastric cancer by Eum, Hye Hyeon, Kwon, Minsuk, Ryu, Daeun, Jo, Areum, Chung, Woosung, Kim, Nayoung, Hong, Yourae, Son, Dae-Soon, Kim, Seung Tae, Lee, Jeeyun, Lee, Hae-Ock, Park, Woong-Yang

“…Gastric cancer (GC) patients develop malignant ascites as the disease progresses owing to peritoneal metastasis. GC patients with malignant ascites have a…”
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Single-cell RNA sequencing of nc886, a non-coding RNA transcribed by RNA polymerase III, with a primer spike-in strategy by Shin, Gyeong-Jin, Choi, Byung-Han, Eum, Hye Hyeon, Jo, Areum, Kim, Nayoung, Kang, Huiram, Hong, Dongwan, Jang, Jiyoung Joan, Lee, Hwi-Ho, Lee, Yeon-Su, Lee, Yong Sun, Lee, Hae-Ock

“…Single-cell RNA sequencing (scRNA-seq) has emerged as a versatile tool in biology, enabling comprehensive genomic-level characterization of individual cells…”
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Clinical Perspectives of Single-Cell RNA Sequencing by Kim, Nayoung, Eum, Hye Hyeon, Lee, Hae-Ock

“…The ability of single-cell genomics to resolve cellular heterogeneity is highly appreciated in cancer and is being exploited for precision medicine. In the…”
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Unveiling the influence of tumor and immune signatures on immune checkpoint therapy in advanced lung cancer by Kim, Nayoung, Park, Sehhoon, Jo, Areum, Eum, Hye Hyeon, Kim, Hong Kwan, Lee, Kyungjong, Cho, Jong Ho, Ku, Bo Mi, Jung, Hyun Ae, Sun, Jong-Mu, Lee, Se-Hoon, Ahn, Jin Seok, Lee, Jung-Il, Choi, Jung Won, Jeong, Dasom, Kang, Huiram, Kim, Jeong Yeon, Choi, Jung Kyoon, Lee, Hae-Ock, Ahn, Myung-Ju

“…This study investigates the variability among patients with non-small cell lung cancer (NSCLC) in their responses to immune checkpoint inhibitors (ICIs)…”
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The regulation of insulin receptor/insulin-like growth factor 1 receptor ratio, an important factor for breast cancer prognosis, by TRIP-Br1 by Nguyen, Thi Ngoc Quynh, Jung, Samil, Nguyen, Hai Anh, Lee, BeomSuk, Vu, Son Hai, Myagmarjav, Davaajargal, Eum, Hye Hyeon, Lee, Hae-Ock, Jo, Taeyeon, Choi, Yeongseon, Lee, Myeong-Sok

“…Much higher risk of cancer has been found in diabetes patients. Insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF1R) have been extensively…”
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Granulocyte Macrophage-Colony Stimulating Factor Produces a Splenic Subset of Monocyte-Derived Dendritic Cells That Efficiently Polarize T Helper Type 2 Cells in Response to Blood-Borne Antigen by Ryu, Seul Hye, Shin, Hyun Soo, Eum, Hye Hyeon, Park, Ji Soo, Choi, Wanho, Na, Hye Young, In, Hyunju, Kim, Tae-Gyun, Park, Sejung, Hwang, Soomin, Sohn, Moah, Kim, Eun-Do, Seo, Kyoung Yul, Lee, Hae-Ock, Lee, Min-Geol, Chu, Min Kyung, Park, Chae Gyu

“…Dendritic cells (DCs) are key antigen-presenting cells that prime naive T cells and initiate adaptive immunity. Although the genetic deficiency and transgenic…”
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Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer by Lee, Hae-Ock, Hong, Yourae, Etlioglu, Hakki Emre, Cho, Yong Beom, Pomella, Valentina, Van den Bosch, Ben, Vanhecke, Jasper, Verbandt, Sara, Hong, Hyekyung, Min, Jae-Woong, Kim, Nayoung, Eum, Hye Hyeon, Qian, Junbin, Boeckx, Bram, Lambrechts, Diether, Tsantoulis, Petros, De Hertogh, Gert, Chung, Woosung, Lee, Taeseob, An, Minae, Shin, Hyun-Tae, Joung, Je-Gun, Jung, Min-Hyeok, Ko, Gunhwan, Wirapati, Pratyaksha, Kim, Seok Hyung, Kim, Hee Cheol, Yun, Seong Hyeon, Tan, Iain Bee Huat, Ranjan, Bobby, Lee, Woo Yong, Kim, Tae-You, Choi, Jung Kyoon, Kim, Young-Joon, Prabhakar, Shyam, Tejpar, Sabine, Park, Woong-Yang

“…Immunotherapy for metastatic colorectal cancer is effective only for mismatch repair-deficient tumors with high microsatellite instability that demonstrate…”
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Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells by Kim, Kyu-Tae, Lee, Hye Won, Lee, Hae-Ock, Kim, Sang Cheol, Seo, Yun Jee, Chung, Woosung, Eum, Hye Hyeon, Nam, Do-Hyun, Kim, Junhyong, Joo, Kyeung Min, Park, Woong-Yang

“…Intra-tumoral genetic and functional heterogeneity correlates with cancer clinical prognoses. However, the mechanisms by which intra-tumoral heterogeneity…”
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CTLA‐4 inhibition facilitates follicular T and B cell interaction and the production of tumor‐specific antibodies by Jo, Areum, Jeong, Dasom, Eum, Hye Hyeon, Kim, Nayoung, Na, Minsu, Kang, Huiram, Lee, Hae‐Ock

“…Immune checkpoint inhibitors (ICIs) induce activation and expansion of cytotoxic T cells. To depict a comprehensive immune cell landscape reshaped by the…”
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Single-cell RNA sequencing reveals myeloid and T cell co-stimulation mediated by IL-7 anti-cancer immunotherapy by Eum, Hye Hyeon, Jeong, Dasom, Kim, Nayoung, Jo, Areum, Na, Minsu, Kang, Huiram, Hong, Yourae, Kong, Jin-Sun, Jeong, Gi Heon, Yoo, Seung-Ah, Lee, Hae-Ock

“…Background Immune checkpoint inhibitors unleash inhibitory signals on T cells conferred by tumors and surrounding stromal cells. Despite the clinical efficacy…”
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SIDR: simultaneous isolation and parallel sequencing of genomic DNA and total RNA from single cells by Han, Kyung Yeon, Kim, Kyu-Tae, Joung, Je-Gun, Son, Dae-Soon, Kim, Yeon Jeong, Jo, Areum, Jeon, Hyo-Jeong, Moon, Hui-Sung, Yoo, Chang Eun, Chung, Woosung, Eum, Hye Hyeon, Kim, Sangmin, Kim, Hong Kwan, Lee, Jeong Eon, Ahn, Myung-Ju, Lee, Hae-Ock, Park, Donghyun, Park, Woong-Yang

“…Simultaneous sequencing of the genome and transcriptome at the single-cell level is a powerful tool for characterizing genomic and transcriptomic variation and…”
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Single-cell mapping of combinatorial target antigens for CAR switches using logic gates by Kwon, Joonha, Kang, Junho, Jo, Areum, Seo, Kayoung, An, Dohyeon, Baykan, Mert Yakup, Lee, Jun Hyeong, Kim, Nayoung, Eum, Hye Hyeon, Hwang, Sohyun, Lee, Ji Min, Park, Woong-Yang, An, Hee Jung, Lee, Hae-Ock, Park, Jong-Eun, Choi, Jung Kyoon

“…Identification of optimal target antigens that distinguish cancer cells from normal surrounding tissue cells remains a key challenge in chimeric antigen…”
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Unveiling the influence of tumor and immune signatures on immune checkpoint therapy in advanced lung cancer by Kim, Nayoung, Park, Sehhoon, Jo, Areum, Eum, Hye Hyeon, Kim, Hong Kwan, Lee, Kyungjong, Cho, Jong Ho, Ku, Bo Mi, Jung, Hyun Ae, Sun, Jong-Mu, Lee, Se-Hoon, Ahn, Jin Seok, Lee, Jung-Il, Choi, Jung Won, Jeong, Dasom, Kang, Huiram, Kim, Jeong Yeon, Choi, Jung Kyoon, Lee, Hae-Ock, Ahn, Myung-Ju

“…This study investigates the variability among patients with non-small cell lung cancer (NSCLC) in their responses to immune checkpoint inhibitors (ICIs)…”
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Abstract 160: Identification of the carcinoma and immune cells in the breast cancer by single-cell RNA sequencing by Chung, Woosung, Eum, Hye Hyeon, Kim, Kyu-Tae, Lee, Kyung-Min, Jo, Arum, Han, WonShik, Lee, Hae-Ock, Park, Woong-Yang

“…Abstract Summary: Breast cancer is a heterogeneous type of cancer accompanying extensive immune cell infiltration. Although its mortality rate has been…”
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Abstract 161: Single-cell RNA sequencing presents explicit expression signatures in primary breast cancer by Eum, Hye Hyeon, Lee, Hae-Ock, Chung, Woosung, Kim, Kyu-Tae, Lee, Kyung-Min, Jo, Arum, Han, WonShik, Park, Woong-Yang

“…Abstract Intratumoral heterogeneity has emerged as a problem to be resolved for precise diagnosis and effective treatment of cancer. Breast cancer is one of…”
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