Search Results - "Eui Soon Park"

Interferon-induced guanylate-binding proteins: Guardians of host defense in health and disease by Tretina, Kyle, Park, Eui-Soon, Maminska, Agnieszka, MacMicking, John D

“…Guanylate-binding proteins (GBPs) have recently emerged as central orchestrators of immunity to infection, inflammation, and neoplastic diseases. Within…”
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Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms by Wandel, Michal P., Kim, Bae-Hoon, Park, Eui-Soon, Boyle, Keith B., Nayak, Komal, Lagrange, Brice, Herod, Adrian, Henry, Thomas, Zilbauer, Matthias, Rohde, John, MacMicking, John D., Randow, Felix

“…Bacterial lipopolysaccharide triggers human caspase-4 (murine caspase-11) to cleave gasdermin-D and induce pyroptotic cell death. How lipopolysaccharide…”
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Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts by Kim, Hyunsoo, Lee, Kyunghee, Kim, Jin Man, Kim, Mi Yeong, Kim, Jae-Ryong, Lee, Han-Woong, Chung, Youn Wook, Shin, Hong-In, Kim, Taesoo, Park, Eui-Soon, Rho, Jaerang, Lee, Seoung Hoon, Kim, Nacksung, Lee, Soo Young, Choi, Yongwon, Jeong, Daewon

“…Selenoproteins containing selenium in the form of selenocysteine are critical for bone remodeling. However, their underlying mechanism of action is not fully…”
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TDAG51 promotes transcription factor FoxO1 activity during LPS‐induced inflammatory responses by Park, Eui‐Soon, Jeon, Hyoeun, Lee, Nari, Yu, Jiyeon, Park, Hye‐Won, Satoh, Takashi, Akira, Shizuo, Furuyama, Tatsuo, Lee, Chul‐Ho, Choi, Jong‐Soon, Rho, Jaerang

“…Tight regulation of Toll‐like receptor (TLR)‐mediated inflammatory responses is important for innate immunity. Here, we show that T‐cell death‐associated gene…”
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Interferon-induced guanylate-binding proteins in inflammasome activation and host defense by Kim, Bae-Hoon, Chee, Jonathan D, Bradfield, Clinton J, Park, Eui-Soon, Kumar, Pradeep, MacMicking, John D

“…In this Perspective, MacMicking and colleagues discuss the roles of interferon-induced guanylate-binding proteins in directing inflammasome responses and their…”
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Native architecture of a human GBP1 defense complex for cell-autonomous immunity to infection by Zhu, Shiwei, Bradfield, Clinton J, Maminska, Agnieszka, Park, Eui-Soon, Kim, Bae-Hoon, Kumar, Pradeep, Huang, Shuai, Kim, Minjeong, Zhang, Yongdeng, Bewersdorf, Joerg, MacMicking, John D

“…All living organisms deploy cell-autonomous defenses to combat infection. In plants and animals, large supramolecular complexes often activate immune proteins…”
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Tumor Necrosis Factor (TNF) Receptor-associated Factor (TRAF)-interacting Protein (TRIP) Negatively Regulates the TRAF2 Ubiquitin-dependent Pathway by Suppressing the TRAF2-Sphingosine 1-Phosphate (S1P) Interaction by Park, Eui-Soon, Choi, Seunga, Shin, Bongjin, Yu, Jungeun, Yu, Jiyeon, Hwang, Jung-Me, Yun, Hyeongseok, Chung, Young-Ho, Choi, Jong-Soon, Choi, Yongwon, Rho, Jaerang

“…Background: TNF receptor-associated factor 2 (TRAF2) is a key adaptor molecule in the TNF receptor (TNFR) signaling pathway. Results: TRAF-interacting protein…”
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TDAG51 is a crucial regulator of maternal care and depressive-like behavior after parturition by Yun, Hyeongseok, Park, Eui-Soon, Choi, Seunga, Shin, Bongjin, Yu, Jungeun, Yu, Jiyeon, Amarasekara, Dulshara Sachini, Kim, Sumi, Lee, Nari, Choi, Jong-Soon, Choi, Yongwon, Rho, Jaerang

“…Postpartum depression is a severe emotional and mental disorder that involves maternal care defects and psychiatric illness. Postpartum depression is closely…”
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NHE10, a novel osteoclast-specific member of the Na +/H + exchanger family, regulates osteoclast differentiation and survival by Lee, Seoung Hoon, Kim, Taesoo, Park, Eui-Soon, Yang, Sujeong, Jeong, Daewon, Choi, Yongwon, Rho, Jaerang

“…Bone homeostasis is tightly regulated by the balanced actions of osteoblasts (OBs) and osteoclasts (OCs). We previously analyzed the gene expression profile of…”
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D-chiro-inositol Negatively Regulates the Formation of Multinucleated Osteoclasts by Down-Regulating NFATc1 by Yu, Jungeun, Choi, Seunga, Park, Eui-Soon, Shin, Bongjin, Yu, Jiyeon, Lee, Seoung Hoon, Takami, Masamichi, Kang, Jong Soon, Meong, Hyungun, Rho, Jaerang

“…Purpose Osteoclasts (OCs) are multinucleated giant cells that resorb bone matrix. Accelerated bone destruction by OCs might cause several metabolic…”
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Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene by Park, Eui-Soon, Choi, Seunga, Kim, Jin-Man, Jeong, Yongsu, Choe, Joonho, Park, Chang-Sik, Choi, Yongwon, Rho, Jaerang

“…Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are key adaptor molecules in the TNFR-signaling complexes that promote a wide variety of…”
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PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection by Xu, Dijin, Jiang, Weiqian, Wu, Lizhen, Gaudet, Ryan G., Park, Eui-Soon, Su, Maohan, Cheppali, Sudheer Kumar, Cheemarla, Nagarjuna R., Kumar, Pradeep, Uchil, Pradeep D., Grover, Jonathan R., Foxman, Ellen F., Brown, Chelsea M., Stansfeld, Phillip J., Bewersdorf, Joerg, Mothes, Walther, Karatekin, Erdem, Wilen, Craig B., MacMicking, John D.

“…Understanding protective immunity to COVID-19 facilitates preparedness for future pandemics and combats new SARS-CoV-2 variants emerging in the human…”
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Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis by Yu, Jiyeon, Yun, Hyeongseok, Shin, Bongjin, Kim, Yongjin, Park, Eui-Soon, Choi, Seunga, Yu, Jungeun, Amarasekara, Dulshara Sachini, Kim, Sumi, Inoue, Jun-ichiro, Walsh, Matthew C., Choi, Yongwon, Takami, Masamichi, Rho, Jaerang

“…The signaling pathway downstream of stimulation of receptor activator of nuclear factor κB (RANK) by RANK ligand is crucial for osteoclastogenesis. RANK…”
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Secretion of a Truncated Osteopetrosis-associated Transmembrane Protein 1 (OSTM1) Mutant Inhibits Osteoclastogenesis through Down-regulation of the B Lymphocyte-induced Maturation Protein 1 (BLIMP1)-Nuclear Factor of Activated T Cells c1 (NFATc1) Axis by Shin, Bongjin, Yu, Jungeun, Park, Eui-Soon, Choi, Seunga, Yu, Jiyeon, Hwang, Jung Me, Yun, Hyeongseok, Chung, Young-Ho, Hong, Kwan Soo, Choi, Jong-Soon, Takami, Masamichi, Rho, Jaerang

“…Genetic mutations in osteoclastogenic genes are closely associated with osteopetrotic bone diseases. Genetic defects in OSTM1 (osteopetrosis-associated…”
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T-Cell Death Associated Gene 51 Is a Novel Negative Regulator of PPARγ That Inhibits PPARγ-RXRα Heterodimer Formation in Adipogenesis by Kim, Sumi, Lee, Nari, Park, Eui-Soon, Yun, Hyeongseok, Ha, Tae-Uk, Jeon, Hyoeun, Yu, Jiyeon, Choi, Seunga, Shin, Bongjin, Yu, Jungeun, Rhee, Sang Dal, Choi, Yongwon, Rho, Jaerang

“…The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is the master transcriptional regulator in adipogenesis. PPARγ forms a heterodimer…”
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Porcine amino peptidase N domain VII has critical role in binding and entry of porcine epidemic diarrhea virus by Kamau, Anthony Ndirangu, Park, Jung-Eun, Park, Eui-Soon, Yu, Jung-Eun, Rho, Jaerang, Shin, Hyun-Jin

“…•To gain insights into mechanisms of PEDV-pAPN interactions, the present study aimed at identifying the domain that is critical for PEDV binding.•Results…”
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Development of transgenic mouse model expressing porcine aminopeptidase N and its susceptibility to porcine epidemic diarrhea virus by Park, Jung-Eun, Park, Eui-Soon, Yu, Jung-Eun, Rho, Jaerang, Paudel, Sarita, Hyun, Bang-Hun, Yang, Dong-Kun, Shin, Hyun-Jin

“…•We developed a transgenic mouse model expressing porcine APN that susceptible to porcine coronavirus infection.•We generated two transgenic mouse lines…”
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ATP6v0d2 deficiency increases bone mass, but does not influence ovariectomy-induced bone loss by Kim, Taesoo, Ha, Hyunil, Kim, Nacksung, Park, Eui-Soon, Rho, Jaerang, Kim, Eun Cheol, Lorenzo, Joseph, Choi, Yongwon, Lee, Seoung Hoon

“…► ATP6v0d2 is not required for OVX-induced trabecular bone loss. ► TRAP+ osteoclasts formation and total TRAP activity were increased in ovariectomized WT and…”
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TDAG51 deficiency promotes oxidative stress-induced apoptosis through the generation of reactive oxygen species in mouse embryonic fibroblasts by Park, Eui-Soon, Kim, Juhyeok, Ha, Tae-uk, Choi, Jong-Soon, Soo Hong, Kwan, Rho, Jaerang

“…Apoptosis has an important role in maintaining tissue homeostasis in cellular stress responses such as inflammation, endoplasmic reticulum stress, and…”
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Protein arginine methyltransferase 1 regulates herpes simplex virus replication through ICP27 RGG-box methylation by Yu, Jungeun, Shin, Bongjin, Park, Eui-Soon, Yang, Sujeong, Choi, Seunga, Kang, Misun, Rho, Jaerang

“…Protein arginine methylation is involved in viral infection and replication through the modulation of diverse cellular processes including RNA metabolism,…”
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