Search Results - "Eugster, HP"

Development and maturation of Langerhans cells, spleen and bone marrow dendritic cells in TNF-α/lymphotoxin-α double-deficient mice by Koch, Franz, Ivarsson, Lennart, Janke, Katrin, Stoitzner, Patrizia, Ryffel, Bernhard, Eugster, Hans-Pietro, Romani, Nikolaus

“…Dendritic cells are key regulators of immunity and tolerance. TNF-α has manifold effects on dendritic cells. It is an indispensable ingredient in several…”
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Nonlymphocyte-derived tumor necrosis factor is required for induction of colitis in recombination activating gene (RAG)2(-/-) mice upon transfer of CD4(+)CD45RB(hi) T cells by Corazza, N, Eichenberger, S, Eugster, H P, Mueller, C

“…In this study, we addressed the role of tumor necrosis factor (TNF)-alpha and lymphotoxin (LT)-alpha in the development of colitis and defined the cellular…”
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IL‐6‐deficient mice resist myelin oligodendrocyte glycoprotein‐induced autoimmune encephalomyelitis by Eugster, Hans‐Pietro, Frei, Karl, Kopf, Manfred, Lassmann, Hans, Fontana, Adriano

“…Experimental autoimmune encephalomyelitis (EAE) is induced by immunization with myelin components including myelin oligodendrocyte glycoprotein (MOG)…”
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Oral Prion Infection Requires Normal Numbers of Peyer's Patches but Not of Enteric Lymphocytes by Prinz, Marco, Huber, Gerhard, Macpherson, Andrew J.S., Heppner, Frank L., Glatzel, Markus, Eugster, Hans-Pietro, Wagner, Norbert, Aguzzi, Adriano

“…Prion pathogenesis following oral exposure is thought to involve gut-associated lymphatic tissue, which includes Peyer's patches (PPs) and M cells. Recruitment…”
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Interleukin-6-deficient mice resist development of autoimmune myocarditis associated with impaired upregulation of complement C3 by ERIKSSON, Urs, KURRER, Michael O, SCHMITZ, Nicole, MARSCH, Stephan C, FONTANA, Adriano, EUGSTER, Hans-Pietro, KOPF, Manfred

“…Interleukin (IL)-6 regulates various aspects of the immune response. In the context of heart diseases, it has been recognized as a prognostic factor for…”
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TNFR1 signalling is critical for the development of demyelination and the limitation of T-cell responses during immune-mediated CNS disease by Probert, Lesley, Eugster, Hans-Pietro, Akassoglou, Katerina, Bauer, Jan, Frei, Karl, Lassmann, Hans, Fontana, Adriano

“…In this review we summarize the essential findings about the function of tumour necrosis factor (TNF) and its cognate receptors TNFR1 and TNFR2, and…”
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Severity of symptoms and demyelination in MOG‐induced EAE depends on TNFR1 by Eugster, Hans‐Pietro, Frei, Karl, Bachmann, Rosilla, Bluethmann, Horst, Lassmann, Hans, Fontana, Adriano

“…The individual role of tumor necrosis factor receptor 1 (TNFR1) and TNFR2 signaling in experimental autoimmune encephalomeylitis (EAE) was investigated using…”
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Transmembrane TNF induces an efficient cell-mediated immunity and resistance to Mycobacterium bovis bacillus Calmette-Guérin infection in the absence of secreted TNF and lymphotoxin-alpha by Olleros, Maria L, Guler, Reto, Corazza, Nadia, Vesin, Dominique, Eugster, Hans-Pietro, Marchal, Gilles, Chavarot, Pierre, Mueller, Christoph, Garcia, Irene

“…The contribution of a transmembrane (Tm) form of TNF to protective immunity against Mycobacterium bovis bacillus Calmette-Guérin (BCG) was studied in…”
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Experimental Closed Head Injury: Analysis of Neurological Outcome, Blood-Brain Barrier Dysfunction, Intracranial Neutrophil Infiltration, and Neuronal Cell Death in Mice Deficient in Genes for Pro-Inflammatory Cytokines by Stahel, Philip F., Shohami, Esther, Younis, Firas M., Kariya, Karin, Otto, Viviane I., Lenzlinger, Philipp M., Grosjean, Maurice B., Eugster, Hans-Pietro, Trentz, Otmar, Kossmann, Thomas, Morganti-Kossmann, Maria C.

“…Cytokines are important mediators of intracranial inflammation following traumatic brain injury (TBI). In the present study, the neurological impairment and…”
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Role of lymphotoxin in experimental models of infectious diseases : Potential benefits and risks of a therapeutic inhibition of the lymphotoxin-β receptor pathway by SPAHN, Thomas W, EUGSTER, Hans-Pietro, FONTANA, Adriano, DOMSCHKE, Wolfram, KUCHARZIK, Torsten

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Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches by Spahn, Thomas W., Fontana, Adriano, Faria, Ana M. C., Slavin, Anthony J., Eugster, Hans‐Pietro, Zhang, Xingmin, Koni, Pandelakis A., Ruddle, Nancy H., Flavell, Richard A., Rennert, Paul D., Weiner, Howard L.

“…Systemic hyporesponsiveness occurs following oral administration of antigen (oral tolerance) and involves the uptake and processing of antigen by the…”
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Tumor necrosis factor alpha and lymphotoxin alpha are not required for induction of acute experimental autoimmune encephalomyelitis by Frei, K, Eugster, H P, Bopst, M, Constantinescu, C S, Lavi, E, Fontana, A

“…Immunization of mice with myelin components results in experimental autoimmune encephalomyelitis (EAE), which is mediated by myelin-specific CD4(+) T cells and…”
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Lethal autoimmune myocarditis in interferon-γ receptor-deficient mice: Enhanced disease severity by impaired inducible nitric oxide synthase induction by ERIKSSON, U, KURRER, M. O, BINGISSER, R, EUGSTER, H. P, SAREMASLANI, P, FOLLATH, F, MARSCH, S, WIDMER, U

“…Interferon-gamma (IFN-gamma) is an essential cytokine in the regulation of inflammatory responses in autoimmune diseases. Little is known about its role in…”
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Induction of reactive oxygen intermediates-dependent programmed cell death in human malignant ex vivo glioma cells and inhibition of the vascular endothelial growth factor production by taurolidine by RODAK, Roksana, KUBOTA, Hisashi, ISHIHARA, Hideyuki, EUGSTER, Hans-Pietro, KÖNÜ, Dilek, MÖHLER, Hanns, YONEKAWA, Yasuhiro, FREI, Karl

“…Taurolidine, a derivative of the amino acid taurin, was recently found to display a potent antineoplastic effect both in vitro and in vivo. The authors…”
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Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signaling by Le Hir, M, Bluethmann, H, Kosco-Vilbois, M H, Müller, M, di Padova, F, Moore, M, Ryffel, B, Eugster, H P

“…Using mice double deficient for tumor necrosis factor (TNF) and lymphotoxin alpha (LT alpha), we demonstrated that TNF and/or LT alpha are necessary for…”
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Impairment of TNF-Receptor-1 Signaling but not Fas Signaling Diminishes T-Cell Apoptosis in Myelin Oligodendrocyte Glycoprotein Peptide-Induced Chronic Demyelinating Autoimmune Encephalomyelitis in Mice by Bachmann, Rosilla, Eugster, Hans-Pietro, Frei, Karl, Fontana, Adriano, Lassmann, Hans

“…T-cell apoptosis in inflammatory demyelinating lesions of chronic myelin oligodendrocyte glycoprotein peptide 35–55 induced autoimmune encephalomyelitis was…”
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Acetaminophen hepatotoxicity in tumor necrosis factor/lymphotoxin‐α gene knockout mice by Boess, Franziska, Bopst, Martin, Althaus, Roland, Polsky, Stacey, Cohen, Steven D., Eugster, Hans‐Pietro, Boelsterli, Urs A.

“…Recent evidence suggests that macrophages and/or other nonparenchymal cells may release important mediators contributing to the hepatic necrosis induced by…”
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TNF/lymphotoxin-alpha double-mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureus by Hultgren, O, Eugster, H P, Sedgwick, J D, Körner, H, Tarkowski, A

“…To evaluate the importance of the proinflammatory cytokines TNF and lymphotoxin-alpha (LT alpha) in an experimental model of Staphylococcus aureus sepsis and…”
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Noncleavable Transmembrane Mouse Tumor Necrosis Factor-α (TNFα) Mediates Effects Distinct from Those of Wild-type TNFα in Vitro and in Vivo by Mueller, Christoph, Corazza, Nadia, Trachsel-Løseth, Sissel, Eugster, Hans-Pietro, Bühler-Jungo, Myriam, Brunner, Thomas, Imboden, Martin A.

“…Tumor necrosis factor- alpha (TNF alpha ) exists in two biologically active forms, a 26-kDa transmembrane form and a proteolytically cleaved and secreted form…”
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Differential effects of TNF and LTα in the host defense against M. bovis BCG by Bopst, Martin, Garcia, Irene, Guler, Reto, Olleros, Maria L., Rülicke, Thomas, Müller, Matthias, Wyss, Stefanie, Frei, Karl, Le Hir, Michel, Eugster, Hans‐Pietro

“…Signaling via TNF receptor type 1 (TNFR1) was shown to be crucial in host defense against the intracellular pathogens L. monocytogenes, M. tuberculosis and M…”
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