Search Results - "Eugene D. Albrecht"

Microvascular Skeletal-Muscle Crosstalk in Health and Disease by Pepe, Gerald J, Albrecht, Eugene D

“…As an organ system, skeletal muscle is essential for the generation of energy that underpins muscle contraction, plays a critical role in controlling energy…”
Get full text

Placental sFlt-1 Gene Delivery in Early Primate Pregnancy Suppresses Uterine Spiral Artery Remodeling by Aberdeen, Graham W, Babischkin, Jeffery S, Lindner, Jonathan R, Pepe, Gerald J, Albrecht, Eugene D

“…Uterine spiral artery remodeling (SAR) is essential for promoting placental perfusion and fetal development. A defect in SAR results in placental ischemia and…”
Get full text

Novel Technologies for Target Delivery of Therapeutics to the Placenta during Pregnancy: A Review by Pepe, Gerald J, Albrecht, Eugene D

“…Uterine spiral artery remodeling is essential for placental perfusion and fetal growth and, when impaired, results in placental ischemia and pregnancy…”
Get full text

Suppression of trophoblast uterine spiral artery remodeling by estrogen during baboon pregnancy: impact on uterine and fetal blood flow dynamics by Aberdeen, Graham W, Bonagura, Thomas W, Harman, Chris R, Pepe, Gerald J, Albrecht, Eugene D

“…The present study was conducted to determine the impact of suppressing trophoblast remodeling of the uterine spiral arteries by prematurely elevating estrogen…”
Get more information

Regulation of Baboon Fetal Ovarian Development by Placental Estrogen: Onset of Puberty Is Delayed in Offspring Deprived of Estrogen In Utero1 by Pepe, Gerald J, Lynch, Terrie J, Albrecht, Eugene D

“…Using the baboon as a model for studies of human reproductive biology, we previously showed that placental estrogen regulates fetal ovarian follicle…”
Get full text

Regulation of Uterine Spiral Artery Remodeling: a Review by Albrecht, Eugene D, Pepe, Gerald J

“…Extravillous trophoblast remodeling of the uterine spiral arteries is essential for promoting blood flow to the placenta and fetal development, but little is…”
Get more information

Vascular Endothelial Growth Factor Mediates the Estrogen-Induced Breakdown of Tight Junctions between and Increase in Proliferation of Microvessel Endothelial Cells in the Baboon Endometrium by Aberdeen, Graham W, Wiegand, Stanley J, Bonagura, Thomas W, Pepe, Gerald J, Albrecht, Eugene D

“…To assess whether there is a link between estrogen, vascular endothelial growth factor (VEGF), and early aspects of uterine angiogenesis, an acute temporal…”
Get full text

Estrogen promotes fetal skeletal muscle mitochondrial distribution and ATP synthase activity important for insulin sensitivity in offspring by Kim, Soon Ok, Albrecht, Eugene D., Pepe, Gerald J.

“…Purpose We previously showed that offspring delivered to baboons in which levels of estradiol (E 2 ) were suppressed during the second half of gestation…”
Get full text

Estrogen Promotes Germ Cell and Seminiferous Tubule Development in the Baboon Fetal Testis by Albrecht, Eugene D, Lane, Malcolm V, Marshall, Gary R, Merchenthaler, Istvan, Simorangkir, David R, Pohl, Clifford R, Plant, Tony M, Pepe, Gerald J

“…The foundation for development of the male reproduction system occurs in utero, but relatively little is known about the regulation of primate fetal testis…”
Get full text

Uterine and fetal blood flow indexes and fetal growth assessment after chronic estrogen suppression in the second half of baboon pregnancy by Aberdeen, Graham W, Baschat, Ahmet A, Harman, Chris R, Weiner, Carl P, Langenberg, Patricia W, Pepe, Gerald J, Albrecht, Eugene D

“…Although estrogen regulates important aspects of maternal cardiovascular physiology, the role of estrogen on uteroplacental and fetal blood flow is…”
Get more information

Estrogen stimulates fetal vascular endothelial growth factor expression and microvascularization by Aberdeen, Graham W, Babischkin, Jeffery S, Pepe, Gerald J, Albrecht, Eugene D

“…We recently showed that the ratio of capillaries to myofibers in skeletal muscle, which accounts for 80% of insulin-directed glucose uptake and metabolism, was…”
Get more information

Estrogen promotes fetal skeletal muscle myofiber development important for insulin sensitivity in offspring by Kim, Soon Ok, Albrecht, Eugene D., Pepe, Gerald J.

“…Using our nonhuman primate baboon model, we showed that offspring born to mothers deprived of estrogen during the second half of gestation exhibited insulin…”
Get full text

Divergent regulation of angiopoietin-1 and -2, Tie-2, and thrombospondin-1 expression by estrogen in the baboon endometrium by Bonagura, Thomas W., Aberdeen, Graham W., Babischkin, Jeffery S., Koos, Robert D., Pepe, Gerald J., Albrecht, Eugene D.

“…Estrogen has an important role in the reconstruction of a new vascular network in the endometrium during each menstrual cycle; however, the underlying…”
Get full text

Developmental Regulation of Baboon Fetal Ovarian Maturation by Estrogen by ZACHOS, Nicholas C, BILLIAR, Reinhart B, ALBRECHT, Eugene D, PEPE, Gerald J

“…Ovarian function in adult human and nonhuman primates is dependent on events that take place during fetal development, including the envelopment of oocytes by…”
Get full text

B-Flow/Spatiotemporal Image Correlation M-Mode and Contrast-Enhanced/Microbubble Ultrasonography Quantification of Spiral Artery Distensibility and Placental Intervillous Perfusion in the First Trimester in a Primate Model of Impaired Spiral Artery Remodeling by Turan, Ozhan M., Babischkin, Jeffery S., Aberdeen, Graham W., Turan, Sifa, Pepe, Gerald J., Albrecht, Eugene D.

“…OBJECTIVEDuring early human pregnancy, placental trophoblasts remodel spiral arteries into distensible low-resistance vessels to promote placental perfusion…”
Get full text

Maternal systemic vascular dysfunction in a primate model of defective uterine spiral artery remodeling by Albrecht, Eugene D, Babischkin, Jeffery S, Aberdeen, Graham W, Burch, Marcia G, Pepe, Gerald J

“…Uterine spiral artery remodeling (UAR) is essential for placental perfusion and fetal development. A defect in UAR underpins placental ischemia disorders,…”
Get more information

Estrogen regulation of placental angiogenesis and fetal ovarian development during primate pregnancy by Albrecht, Eugene D, Pepe, Gerald J

“…During human and nonhuman primate pregnancy, an extensive blood vessel network is established within the villous placenta to support fetal growth and follicles…”
Get full text

Vascular Endothelial Growth Factor Delivery to Placental Basal Plate Promotes Uterine Artery Remodeling in the Primate by Babischkin, Jeffery S, Aberdeen, Graham W, Lindner, Jonathan R, Bonagura, Thomas W, Pepe, Gerald J, Albrecht, Eugene D

“…Abstract Extravillous trophoblast (EVT) uterine artery remodeling (UAR) promotes placental blood flow, but UAR regulation is unproven. Elevating estradiol (E2)…”
Get full text

Quantification of Protein Expression by Proximity Ligation Assay in the Nonhuman Primate in Response to Estrogen by Bonagura, Thomas W, Babischkin, Jeffery S, Pepe, Gerald J, Albrecht, Eugene D

“…In the field of protein biology, immunology-based techniques are continuously evolving for the detection and quantification of individual protein levels,…”
Get more information

Regulation of Baboon Fetal Pituitary Prolactin Expression by Estrogen by Pepe, Gerald J, Lynch, Terrie J, Davies, William A, Albrecht, Eugene D

“…We previously showed that fetal adrenal fetal zone growth was increased and the number of follicles in the fetal ovary reduced in baboons in which estradiol…”
Get full text