(Pro)renin Receptor Expression Increases throughout the Colorectal Adenoma-Adenocarcinoma Sequence and It Is Associated with Worse Colorectal Cancer Prognosis

(Pro)renin Receptor Expression Increases throughout the Colorectal Adenoma-Adenocarcinoma Sequence and It Is Associated with Worse Colorectal Cancer Prognosis

(Pro)renin receptor (PRR) is a protein that takes part in several signaling pathways such as Renin Angiotensin System and Wnt signalling. Its biological role has recently been related to cancer progression and in this study, we investigated its relevance in colorectal cancer (CRC). To that end, we a...

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Bibliographic Details
Published in:Cancers Vol. 11; no. 6; p. 881
Main Authors: Beitia, Maider, Solano-Iturri, Jon Danel, Errarte, Peio, Calvete-Candenas, Julio, Loizate, Alberto, Etxezarraga, Mari Carmen, Sanz, Begoña, Larrinaga, Gorka
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 24-06-2019
MDPI
Subjects:
Adenocarcinoma
Adenoma
Age
Angiotensin
Biomarkers
Colorectal cancer
Colorectal carcinoma
Enzyme-linked immunosorbent assay
Enzymes
Gender
Hospitals
Medical prognosis
Metastases
Metastasis
Mucosa
Nursing
Pathology
Peptides
Polyps
Protein expression
Proteins
Renin
Signal transduction
Therapeutic applications
Tumors
Wnt protein
Spain
adenoma
colorectal cancer
vATPase
biomarkers
angiotensin
Wnt
(pro)renin receptor
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Summary:(Pro)renin receptor (PRR) is a protein that takes part in several signaling pathways such as Renin Angiotensin System and Wnt signalling. Its biological role has recently been related to cancer progression and in this study, we investigated its relevance in colorectal cancer (CRC). To that end, we analysed the immunohistochemical expression of PRR in adenomatous polyps and CRCs from the same patients ( = 42), and in primary tumours and nodal and liver metastases from advanced CRC patients ( = 294). In addition, the soluble fraction of PRR was measured by ELISA in plasma samples from 161 CRC patients. The results showed that PRR expression was gradually augmented along the uninvolved mucosa-adenoma-adenocarcinoma sequence. Besides, the stronger expression of PRR in primary tumours was markedly associated with local tumour extent and the onset of metastases. Moreover, PRR expression in both primary and distant metastases was associated with worse 5- and 10-year survival of CRC patients. Plasmatic PRR levels did not change with respect to controls and were not associated with CRC aggressiveness. These results suggest a key role of PRR in the development and progression of CRC and a potential use of this protein as a new prognostic biomarker and/or therapeutic target for this disease.
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ISSN:2072-6694
2072-6694
DOI:10.3390/cancers11060881